Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats
Abstract The toxicity of Tityus bahiensis scorpion venom is well known, but there are little data about the damage in offspring of dams that were exposed to the venom during pregnancy. The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to...
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| Veröffentlicht in: | Neurotoxicology and teratology 2010-03, Vol.32 (2), p.187-192 |
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| creator | Dorce, Ana Leticia Coronado Dorce, Valquiria Abrão Coronado Nencioni, Ana Leonor Abrahão |
| description | Abstract The toxicity of Tityus bahiensis scorpion venom is well known, but there are little data about the damage in offspring of dams that were exposed to the venom during pregnancy. The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to venom in utero . Dams were divided into a control group, subcutaneously injected with saline solution on the 10th (GD10) and 16th (GD16) days, and two experimental groups, subcutaneously injected with venom (2.5 mg/kg) on GD10 or GD16, respectively. Adult offspring were evaluated according to behavioral development and neuronal integrity in the hippocampus. Tests performed in the activity box and in the enriched environment demonstrated that males from GD10 had motor decrease. Females from GD10 showed a depressive-like state and were more anxious, as demonstrated by the forced swimming test and social interaction. The plus-maze discriminative avoidance task demonstrated that GD16 males had lower levels of anxiety. The number of neuronal cells was decreased in CA1, CA3 and CA4 hippocampal areas of males and females from GD10 group and in CA1 of females and CA4 of males from GD16 group. Thus, we conclude that venom exposure in pregnant dams causes subtle alteration in the behavioral and neuronal development of offspring in adult life in a gender-dependent manner. |
| doi_str_mv | 10.1016/j.ntt.2009.11.002 |
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The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to venom in utero . Dams were divided into a control group, subcutaneously injected with saline solution on the 10th (GD10) and 16th (GD16) days, and two experimental groups, subcutaneously injected with venom (2.5 mg/kg) on GD10 or GD16, respectively. Adult offspring were evaluated according to behavioral development and neuronal integrity in the hippocampus. Tests performed in the activity box and in the enriched environment demonstrated that males from GD10 had motor decrease. Females from GD10 showed a depressive-like state and were more anxious, as demonstrated by the forced swimming test and social interaction. The plus-maze discriminative avoidance task demonstrated that GD16 males had lower levels of anxiety. The number of neuronal cells was decreased in CA1, CA3 and CA4 hippocampal areas of males and females from GD10 group and in CA1 of females and CA4 of males from GD16 group. Thus, we conclude that venom exposure in pregnant dams causes subtle alteration in the behavioral and neuronal development of offspring in adult life in a gender-dependent manner.</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/j.ntt.2009.11.002</identifier><identifier>PMID: 19945531</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult animals ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Behavioral development ; Cell Death - drug effects ; Cell Death - physiology ; Child, Preschool ; Depressive Disorder - chemically induced ; Depressive Disorder - physiopathology ; Developmental Disabilities - chemically induced ; Developmental Disabilities - physiopathology ; Emergency ; Envenomation ; Female ; Hippocampus - drug effects ; Hippocampus - growth & development ; Hippocampus - pathology ; Humans ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Medical Education ; Mental Disorders - chemically induced ; Mental Disorders - physiopathology ; Nerve Degeneration - chemically induced ; Nerve Degeneration - pathology ; Nerve Degeneration - physiopathology ; Neuropsychological Tests ; Neurotoxicity Syndromes - physiopathology ; Pregnancy ; Prenatal Exposure Delayed Effects - physiopathology ; Rats ; Rats, Wistar ; Scorpion venom ; Scorpion Venoms - toxicity ; Sex Characteristics ; Sex Factors ; Tityus bahiensis ; Toxicity</subject><ispartof>Neurotoxicology and teratology, 2010-03, Vol.32 (2), p.187-192</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>Copyright (c) 2009 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-af3dc9682d9f8381bc0743881360f9bee4b26a1c032f53be9d876b23158f17653</citedby><cites>FETCH-LOGICAL-c439t-af3dc9682d9f8381bc0743881360f9bee4b26a1c032f53be9d876b23158f17653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ntt.2009.11.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19945531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dorce, Ana Leticia Coronado</creatorcontrib><creatorcontrib>Dorce, Valquiria Abrão Coronado</creatorcontrib><creatorcontrib>Nencioni, Ana Leonor Abrahão</creatorcontrib><title>Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Abstract The toxicity of Tityus bahiensis scorpion venom is well known, but there are little data about the damage in offspring of dams that were exposed to the venom during pregnancy. The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to venom in utero . Dams were divided into a control group, subcutaneously injected with saline solution on the 10th (GD10) and 16th (GD16) days, and two experimental groups, subcutaneously injected with venom (2.5 mg/kg) on GD10 or GD16, respectively. Adult offspring were evaluated according to behavioral development and neuronal integrity in the hippocampus. Tests performed in the activity box and in the enriched environment demonstrated that males from GD10 had motor decrease. Females from GD10 showed a depressive-like state and were more anxious, as demonstrated by the forced swimming test and social interaction. The plus-maze discriminative avoidance task demonstrated that GD16 males had lower levels of anxiety. The number of neuronal cells was decreased in CA1, CA3 and CA4 hippocampal areas of males and females from GD10 group and in CA1 of females and CA4 of males from GD16 group. Thus, we conclude that venom exposure in pregnant dams causes subtle alteration in the behavioral and neuronal development of offspring in adult life in a gender-dependent manner.</description><subject>Adult animals</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral development</subject><subject>Cell Death - drug effects</subject><subject>Cell Death - physiology</subject><subject>Child, Preschool</subject><subject>Depressive Disorder - chemically induced</subject><subject>Depressive Disorder - physiopathology</subject><subject>Developmental Disabilities - chemically induced</subject><subject>Developmental Disabilities - physiopathology</subject><subject>Emergency</subject><subject>Envenomation</subject><subject>Female</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Medical Education</subject><subject>Mental Disorders - chemically induced</subject><subject>Mental Disorders - physiopathology</subject><subject>Nerve Degeneration - chemically induced</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Degeneration - physiopathology</subject><subject>Neuropsychological Tests</subject><subject>Neurotoxicity Syndromes - physiopathology</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Scorpion venom</subject><subject>Scorpion Venoms - toxicity</subject><subject>Sex Characteristics</subject><subject>Sex Factors</subject><subject>Tityus bahiensis</subject><subject>Toxicity</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0B7iR7Fy1npO0aYIgyDB-wIgLx3Vo0xPMtbe5Ju3g_fem3AuCC1dn874PnOdl7CVCjYDqzb6el6UWAKZGrAHEI7ZD3YnKdFI_ZjvQRlQglbhiz3LeA0CnEJ6yKzSmaVuJO_bl1ntyS-bR8zDzdaEUOf0-xrwm4kvk92E5rZkP_Y9Acw6ZZxfTMcSZP9AcD1upH9dp4alf8nP2xPdTpheXe82-f7i9v_lU3X39-Pnm_V3lGmmWqvdydEZpMRqvpcbBQddIrVEq8GYgagahenQghW_lQGbUnRqExFZ77FQrr9nrM_eY4q-V8mIPITuapn6muGbbNaoQGy1LEs9Jl2LOibw9pnDo08ki2E2i3dsi0W4SLaItEkvn1YW-Dgca_zYu1krg7TlA5ceHQMlmV-w4GkMqMu0Yw3_x7_5puynMwfXTTzpR3sc1zUWeRZuFBfttW3EbEQwAGiXkH08qlrE</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Dorce, Ana Leticia Coronado</creator><creator>Dorce, Valquiria Abrão Coronado</creator><creator>Nencioni, Ana Leonor Abrahão</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20100301</creationdate><title>Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats</title><author>Dorce, Ana Leticia Coronado ; Dorce, Valquiria Abrão Coronado ; Nencioni, Ana Leonor Abrahão</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-af3dc9682d9f8381bc0743881360f9bee4b26a1c032f53be9d876b23158f17653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult animals</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral development</topic><topic>Cell Death - drug effects</topic><topic>Cell Death - physiology</topic><topic>Child, Preschool</topic><topic>Depressive Disorder - chemically induced</topic><topic>Depressive Disorder - physiopathology</topic><topic>Developmental Disabilities - chemically induced</topic><topic>Developmental Disabilities - physiopathology</topic><topic>Emergency</topic><topic>Envenomation</topic><topic>Female</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Medical Education</topic><topic>Mental Disorders - chemically induced</topic><topic>Mental Disorders - physiopathology</topic><topic>Nerve Degeneration - chemically induced</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Degeneration - physiopathology</topic><topic>Neuropsychological Tests</topic><topic>Neurotoxicity Syndromes - physiopathology</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Scorpion venom</topic><topic>Scorpion Venoms - toxicity</topic><topic>Sex Characteristics</topic><topic>Sex Factors</topic><topic>Tityus bahiensis</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dorce, Ana Leticia Coronado</creatorcontrib><creatorcontrib>Dorce, Valquiria Abrão Coronado</creatorcontrib><creatorcontrib>Nencioni, Ana Leonor Abrahão</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dorce, Ana Leticia Coronado</au><au>Dorce, Valquiria Abrão Coronado</au><au>Nencioni, Ana Leonor Abrahão</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>32</volume><issue>2</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><abstract>Abstract The toxicity of Tityus bahiensis scorpion venom is well known, but there are little data about the damage in offspring of dams that were exposed to the venom during pregnancy. The objective of this work was to determine the toxic effects of venom in adult offspring of Wistar rats exposed to venom in utero . Dams were divided into a control group, subcutaneously injected with saline solution on the 10th (GD10) and 16th (GD16) days, and two experimental groups, subcutaneously injected with venom (2.5 mg/kg) on GD10 or GD16, respectively. Adult offspring were evaluated according to behavioral development and neuronal integrity in the hippocampus. Tests performed in the activity box and in the enriched environment demonstrated that males from GD10 had motor decrease. Females from GD10 showed a depressive-like state and were more anxious, as demonstrated by the forced swimming test and social interaction. The plus-maze discriminative avoidance task demonstrated that GD16 males had lower levels of anxiety. The number of neuronal cells was decreased in CA1, CA3 and CA4 hippocampal areas of males and females from GD10 group and in CA1 of females and CA4 of males from GD16 group. Thus, we conclude that venom exposure in pregnant dams causes subtle alteration in the behavioral and neuronal development of offspring in adult life in a gender-dependent manner.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19945531</pmid><doi>10.1016/j.ntt.2009.11.002</doi><tpages>6</tpages></addata></record> |
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| ispartof | Neurotoxicology and teratology, 2010-03, Vol.32 (2), p.187-192 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult animals Animals Behavior, Animal - drug effects Behavior, Animal - physiology Behavioral development Cell Death - drug effects Cell Death - physiology Child, Preschool Depressive Disorder - chemically induced Depressive Disorder - physiopathology Developmental Disabilities - chemically induced Developmental Disabilities - physiopathology Emergency Envenomation Female Hippocampus - drug effects Hippocampus - growth & development Hippocampus - pathology Humans Male Maze Learning - drug effects Maze Learning - physiology Medical Education Mental Disorders - chemically induced Mental Disorders - physiopathology Nerve Degeneration - chemically induced Nerve Degeneration - pathology Nerve Degeneration - physiopathology Neuropsychological Tests Neurotoxicity Syndromes - physiopathology Pregnancy Prenatal Exposure Delayed Effects - physiopathology Rats Rats, Wistar Scorpion venom Scorpion Venoms - toxicity Sex Characteristics Sex Factors Tityus bahiensis Toxicity |
| title | Effects of in utero exposure to Tityus bahiensis scorpion venom in adult rats |
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