Primary lymphoma of bone in adult patients
BACKGROUND: The low incidence of primary lymphoma of bone (PLB) has led to discrepancies in classification as well as difficulty in prognostication. The authors of this report used the Surveillance, Epidemiology, and End Results (SEER) database to analyze a large, population‐based cohort of adult pa...
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| Veröffentlicht in: | Cancer 2010-02, Vol.116 (4), p.871-879 |
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| creator | Jawad, Muhammad U. Schneiderbauer, Michaela M. Min, Elijah S. Cheung, Michael C. Koniaris, Leonidas G. Scully, Sean P. |
| description | BACKGROUND:
The low incidence of primary lymphoma of bone (PLB) has led to discrepancies in classification as well as difficulty in prognostication. The authors of this report used the Surveillance, Epidemiology, and End Results (SEER) database to analyze a large, population‐based cohort of adult patients with this disease. The database provides a standardized classification and documentation of outcomes and enables a meaningful evaluation of prognostic factors.
METHODS:
The SEER database was used to identify all patients who were diagnosed with PLB from 1973 through 2005. Survival was analyzed with the Kaplan‐Meier method, and the influence of clinical parameters on survival was analyzed with the log‐rank test. A Cox proportional hazards model was used for multivariate analysis.
RESULTS:
Fifteen hundred adult patients with PLB were analyzed. The 5‐year and 10‐year survival rates for adult patients were 58% and 45%, respectively. Multivariate analysis revealed that younger age and localized disease were independent predictors of survival. It is noteworthy that the incidence of disease, as determined by the annual percentage change, increased during the study period (P < .05).
CONCLUSIONS:
This analysis of a large cohort of adults with PLB indicated that the only identifiable prognostic indicators were localized disease and younger age. The authors concluded that future treatment for patients with PLB need to be based on strict staging criteria and adherence to successful published protocols using collaborative clinical trials. Cancer 2010. © 2010 American Cancer Society
In this study, 1500 adult patients with primary lymphoma of bone had 5‐year and 10‐year survival rates of 58% and 45%, respectively. An improved prognosis was associated with a single bone lesion and younger patient age. These variables were identified as independent prognostic factors and indicated that this subgroup of patients may be amenable to more focused treatment. |
| doi_str_mv | 10.1002/cncr.24828 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746052061</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1257739336</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5258-65d644a280c619202930732bfe8eb16f8ae0ff221d2a41156d65bbb27ae13e0a3</originalsourceid><addsrcrecordid>eNqF0EtLw0AQwPFFFFurFz-A5CJKIXV29pmjBF9QVETBW9gkG4zkZTZB-u1NTdVbPQ0DP2bgT8gxhQUFwIukStoFco16h0wpBMoHynGXTAFA-4Kz1wk5cO59WBUKtk8mCMAZQz4l88c2L0278opV2bzVpfHqzIvrynp55Zm0LzqvMV1uq84dkr3MFM4ebeaMvFxfPYe3_vLh5i68XPqJQKF9KVLJuUENiaQBAgYMFMM4s9rGVGbaWMgyRJqi4ZQKmUoRxzEqYymzYNiMnI13m7b-6K3rojJ3iS0KU9m6d5HiEgSCpP9LxqQapBzk-VZJUSjFgsEPdD7SpK2da20WNWOiiEK07h2te0ffvQd8srnbx6VNf-lP4AGcboBxiSmy1lRJ7v4cskBpjYOjo_vMC7va8jIK78On8fkX90OUnw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1257739336</pqid></control><display><type>article</type><title>Primary lymphoma of bone in adult patients</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Jawad, Muhammad U. ; Schneiderbauer, Michaela M. ; Min, Elijah S. ; Cheung, Michael C. ; Koniaris, Leonidas G. ; Scully, Sean P.</creator><creatorcontrib>Jawad, Muhammad U. ; Schneiderbauer, Michaela M. ; Min, Elijah S. ; Cheung, Michael C. ; Koniaris, Leonidas G. ; Scully, Sean P.</creatorcontrib><description>BACKGROUND:
The low incidence of primary lymphoma of bone (PLB) has led to discrepancies in classification as well as difficulty in prognostication. The authors of this report used the Surveillance, Epidemiology, and End Results (SEER) database to analyze a large, population‐based cohort of adult patients with this disease. The database provides a standardized classification and documentation of outcomes and enables a meaningful evaluation of prognostic factors.
METHODS:
The SEER database was used to identify all patients who were diagnosed with PLB from 1973 through 2005. Survival was analyzed with the Kaplan‐Meier method, and the influence of clinical parameters on survival was analyzed with the log‐rank test. A Cox proportional hazards model was used for multivariate analysis.
RESULTS:
Fifteen hundred adult patients with PLB were analyzed. The 5‐year and 10‐year survival rates for adult patients were 58% and 45%, respectively. Multivariate analysis revealed that younger age and localized disease were independent predictors of survival. It is noteworthy that the incidence of disease, as determined by the annual percentage change, increased during the study period (P < .05).
CONCLUSIONS:
This analysis of a large cohort of adults with PLB indicated that the only identifiable prognostic indicators were localized disease and younger age. The authors concluded that future treatment for patients with PLB need to be based on strict staging criteria and adherence to successful published protocols using collaborative clinical trials. Cancer 2010. © 2010 American Cancer Society
In this study, 1500 adult patients with primary lymphoma of bone had 5‐year and 10‐year survival rates of 58% and 45%, respectively. An improved prognosis was associated with a single bone lesion and younger patient age. These variables were identified as independent prognostic factors and indicated that this subgroup of patients may be amenable to more focused treatment.</description><identifier>ISSN: 0008-543X</identifier><identifier>ISSN: 1097-0142</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.24828</identifier><identifier>PMID: 20043324</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Bone Neoplasms - diagnosis ; Bone Neoplasms - mortality ; Bone Neoplasms - therapy ; Female ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma - classification ; Lymphoma - diagnosis ; Lymphoma - mortality ; Lymphoma - therapy ; Male ; Medical sciences ; Middle Aged ; Population Surveillance ; primary lymphoma of bone ; Prognosis ; radiation therapy ; SEER Program ; staging ; survival ; Survival Rate ; Tumors</subject><ispartof>Cancer, 2010-02, Vol.116 (4), p.871-879</ispartof><rights>Copyright © 2010 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5258-65d644a280c619202930732bfe8eb16f8ae0ff221d2a41156d65bbb27ae13e0a3</citedby><cites>FETCH-LOGICAL-c5258-65d644a280c619202930732bfe8eb16f8ae0ff221d2a41156d65bbb27ae13e0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.24828$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.24828$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22397882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20043324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jawad, Muhammad U.</creatorcontrib><creatorcontrib>Schneiderbauer, Michaela M.</creatorcontrib><creatorcontrib>Min, Elijah S.</creatorcontrib><creatorcontrib>Cheung, Michael C.</creatorcontrib><creatorcontrib>Koniaris, Leonidas G.</creatorcontrib><creatorcontrib>Scully, Sean P.</creatorcontrib><title>Primary lymphoma of bone in adult patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
The low incidence of primary lymphoma of bone (PLB) has led to discrepancies in classification as well as difficulty in prognostication. The authors of this report used the Surveillance, Epidemiology, and End Results (SEER) database to analyze a large, population‐based cohort of adult patients with this disease. The database provides a standardized classification and documentation of outcomes and enables a meaningful evaluation of prognostic factors.
METHODS:
The SEER database was used to identify all patients who were diagnosed with PLB from 1973 through 2005. Survival was analyzed with the Kaplan‐Meier method, and the influence of clinical parameters on survival was analyzed with the log‐rank test. A Cox proportional hazards model was used for multivariate analysis.
RESULTS:
Fifteen hundred adult patients with PLB were analyzed. The 5‐year and 10‐year survival rates for adult patients were 58% and 45%, respectively. Multivariate analysis revealed that younger age and localized disease were independent predictors of survival. It is noteworthy that the incidence of disease, as determined by the annual percentage change, increased during the study period (P < .05).
CONCLUSIONS:
This analysis of a large cohort of adults with PLB indicated that the only identifiable prognostic indicators were localized disease and younger age. The authors concluded that future treatment for patients with PLB need to be based on strict staging criteria and adherence to successful published protocols using collaborative clinical trials. Cancer 2010. © 2010 American Cancer Society
In this study, 1500 adult patients with primary lymphoma of bone had 5‐year and 10‐year survival rates of 58% and 45%, respectively. An improved prognosis was associated with a single bone lesion and younger patient age. These variables were identified as independent prognostic factors and indicated that this subgroup of patients may be amenable to more focused treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - therapy</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma - classification</subject><subject>Lymphoma - diagnosis</subject><subject>Lymphoma - mortality</subject><subject>Lymphoma - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Population Surveillance</subject><subject>primary lymphoma of bone</subject><subject>Prognosis</subject><subject>radiation therapy</subject><subject>SEER Program</subject><subject>staging</subject><subject>survival</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLw0AQwPFFFFurFz-A5CJKIXV29pmjBF9QVETBW9gkG4zkZTZB-u1NTdVbPQ0DP2bgT8gxhQUFwIukStoFco16h0wpBMoHynGXTAFA-4Kz1wk5cO59WBUKtk8mCMAZQz4l88c2L0278opV2bzVpfHqzIvrynp55Zm0LzqvMV1uq84dkr3MFM4ebeaMvFxfPYe3_vLh5i68XPqJQKF9KVLJuUENiaQBAgYMFMM4s9rGVGbaWMgyRJqi4ZQKmUoRxzEqYymzYNiMnI13m7b-6K3rojJ3iS0KU9m6d5HiEgSCpP9LxqQapBzk-VZJUSjFgsEPdD7SpK2da20WNWOiiEK07h2te0ffvQd8srnbx6VNf-lP4AGcboBxiSmy1lRJ7v4cskBpjYOjo_vMC7va8jIK78On8fkX90OUnw</recordid><startdate>20100215</startdate><enddate>20100215</enddate><creator>Jawad, Muhammad U.</creator><creator>Schneiderbauer, Michaela M.</creator><creator>Min, Elijah S.</creator><creator>Cheung, Michael C.</creator><creator>Koniaris, Leonidas G.</creator><creator>Scully, Sean P.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope><scope>7QP</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100215</creationdate><title>Primary lymphoma of bone in adult patients</title><author>Jawad, Muhammad U. ; Schneiderbauer, Michaela M. ; Min, Elijah S. ; Cheung, Michael C. ; Koniaris, Leonidas G. ; Scully, Sean P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5258-65d644a280c619202930732bfe8eb16f8ae0ff221d2a41156d65bbb27ae13e0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Bone Neoplasms - diagnosis</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - therapy</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma - classification</topic><topic>Lymphoma - diagnosis</topic><topic>Lymphoma - mortality</topic><topic>Lymphoma - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Population Surveillance</topic><topic>primary lymphoma of bone</topic><topic>Prognosis</topic><topic>radiation therapy</topic><topic>SEER Program</topic><topic>staging</topic><topic>survival</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jawad, Muhammad U.</creatorcontrib><creatorcontrib>Schneiderbauer, Michaela M.</creatorcontrib><creatorcontrib>Min, Elijah S.</creatorcontrib><creatorcontrib>Cheung, Michael C.</creatorcontrib><creatorcontrib>Koniaris, Leonidas G.</creatorcontrib><creatorcontrib>Scully, Sean P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jawad, Muhammad U.</au><au>Schneiderbauer, Michaela M.</au><au>Min, Elijah S.</au><au>Cheung, Michael C.</au><au>Koniaris, Leonidas G.</au><au>Scully, Sean P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary lymphoma of bone in adult patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2010-02-15</date><risdate>2010</risdate><volume>116</volume><issue>4</issue><spage>871</spage><epage>879</epage><pages>871-879</pages><issn>0008-543X</issn><issn>1097-0142</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
The low incidence of primary lymphoma of bone (PLB) has led to discrepancies in classification as well as difficulty in prognostication. The authors of this report used the Surveillance, Epidemiology, and End Results (SEER) database to analyze a large, population‐based cohort of adult patients with this disease. The database provides a standardized classification and documentation of outcomes and enables a meaningful evaluation of prognostic factors.
METHODS:
The SEER database was used to identify all patients who were diagnosed with PLB from 1973 through 2005. Survival was analyzed with the Kaplan‐Meier method, and the influence of clinical parameters on survival was analyzed with the log‐rank test. A Cox proportional hazards model was used for multivariate analysis.
RESULTS:
Fifteen hundred adult patients with PLB were analyzed. The 5‐year and 10‐year survival rates for adult patients were 58% and 45%, respectively. Multivariate analysis revealed that younger age and localized disease were independent predictors of survival. It is noteworthy that the incidence of disease, as determined by the annual percentage change, increased during the study period (P < .05).
CONCLUSIONS:
This analysis of a large cohort of adults with PLB indicated that the only identifiable prognostic indicators were localized disease and younger age. The authors concluded that future treatment for patients with PLB need to be based on strict staging criteria and adherence to successful published protocols using collaborative clinical trials. Cancer 2010. © 2010 American Cancer Society
In this study, 1500 adult patients with primary lymphoma of bone had 5‐year and 10‐year survival rates of 58% and 45%, respectively. An improved prognosis was associated with a single bone lesion and younger patient age. These variables were identified as independent prognostic factors and indicated that this subgroup of patients may be amenable to more focused treatment.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20043324</pmid><doi>10.1002/cncr.24828</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Age Factors Biological and medical sciences Bone Neoplasms - diagnosis Bone Neoplasms - mortality Bone Neoplasms - therapy Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma - classification Lymphoma - diagnosis Lymphoma - mortality Lymphoma - therapy Male Medical sciences Middle Aged Population Surveillance primary lymphoma of bone Prognosis radiation therapy SEER Program staging survival Survival Rate Tumors |
| title | Primary lymphoma of bone in adult patients |
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