Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies
Objective To provide an overview of prognostic factors of knee osteoarthritis (OA) progression. Methods We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were asse...
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| Veröffentlicht in: | Arthritis and rheumatism 2007-02, Vol.57 (1), p.13-26 |
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| creator | Belo, J. N. Berger, M. Y. Reijman, M. Koes, B. W. Bierma‐Zeinstra, S. M. A. |
| description | Objective
To provide an overview of prognostic factors of knee osteoarthritis (OA) progression.
Methods
We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis.
Results
Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only high‐quality studies were included (n = 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA.
Conclusion
Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting. |
| doi_str_mv | 10.1002/art.22475 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746051388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69037170</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4165-40b1d47916fd54a3ec85261bd9a4131eeaa116968310edaee28b37ea6a07f41f3</originalsourceid><addsrcrecordid>eNqFkUtv1UAMhUcIRC-FBX8AZQOIRVp7nkl3VxUvqRIIlXU0SRw6kGTKOLfV_ffMfUhdAauR7W_OkX2EeIlwhgDy3KflTErtzCOxQiPrElDhY7ECAF0qU-OJeMb8M5dSGfVUnKCT1kIFKzF9TfHHHHkJXTH4bomJizgUt7mbiDnEeVfmOcXscpPCEvbAckPFr5noolgXvM3jye8kEt0Fut9_aZnSXW7G2Y8FL5s-ED8XTwY_Mr04vqfi-4f315efyqsvHz9frq_KTqM1pYYWe-1qtENvtFfUVUZabPva67wZkfeItraVQqDeE8mqVY689eAGjYM6FW8PunmP3xvipZkCdzSOfqa44cZpCwZVVWXyzT9JW4Ny6OC_oARltJMug-8OYJcic6KhuU1h8mnbIDS7uJp8yGYfV2ZfHUU37UT9A3nMJwOvj4Dnzo9D8nMX-IGrDNbW7oTOD9x9GGn7d8dm_e36YP0HVtSs6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20354727</pqid></control><display><type>article</type><title>Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><creator>Belo, J. N. ; Berger, M. Y. ; Reijman, M. ; Koes, B. W. ; Bierma‐Zeinstra, S. M. A.</creator><creatorcontrib>Belo, J. N. ; Berger, M. Y. ; Reijman, M. ; Koes, B. W. ; Bierma‐Zeinstra, S. M. A.</creatorcontrib><description>Objective
To provide an overview of prognostic factors of knee osteoarthritis (OA) progression.
Methods
We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis.
Results
Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only high‐quality studies were included (n = 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA.
Conclusion
Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.</description><identifier>ISSN: 0004-3591</identifier><identifier>ISSN: 0893-7524</identifier><identifier>EISSN: 1529-0131</identifier><identifier>EISSN: 1529-0123</identifier><identifier>DOI: 10.1002/art.22475</identifier><identifier>PMID: 17266080</identifier><identifier>CODEN: ARCREG</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Disease Progression ; Diseases of the osteoarticular system ; Female ; Humans ; Hyaluronic Acid - blood ; Knee ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Osteoarthritis ; Osteoarthritis, Knee - blood ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - physiopathology ; Predictive Value of Tests ; Prognosis ; Prognostic factors ; Progression ; Radiography ; Systematic review</subject><ispartof>Arthritis and rheumatism, 2007-02, Vol.57 (1), p.13-26</ispartof><rights>Copyright © 2007 by the American College of Rheumatology</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4165-40b1d47916fd54a3ec85261bd9a4131eeaa116968310edaee28b37ea6a07f41f3</citedby><cites>FETCH-LOGICAL-c4165-40b1d47916fd54a3ec85261bd9a4131eeaa116968310edaee28b37ea6a07f41f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.22475$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.22475$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18519665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17266080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belo, J. N.</creatorcontrib><creatorcontrib>Berger, M. Y.</creatorcontrib><creatorcontrib>Reijman, M.</creatorcontrib><creatorcontrib>Koes, B. W.</creatorcontrib><creatorcontrib>Bierma‐Zeinstra, S. M. A.</creatorcontrib><title>Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Objective
To provide an overview of prognostic factors of knee osteoarthritis (OA) progression.
Methods
We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis.
Results
Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only high‐quality studies were included (n = 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA.
Conclusion
Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Humans</subject><subject>Hyaluronic Acid - blood</subject><subject>Knee</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - blood</subject><subject>Osteoarthritis, Knee - diagnostic imaging</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Progression</subject><subject>Radiography</subject><subject>Systematic review</subject><issn>0004-3591</issn><issn>0893-7524</issn><issn>1529-0131</issn><issn>1529-0123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1UAMhUcIRC-FBX8AZQOIRVp7nkl3VxUvqRIIlXU0SRw6kGTKOLfV_ffMfUhdAauR7W_OkX2EeIlwhgDy3KflTErtzCOxQiPrElDhY7ECAF0qU-OJeMb8M5dSGfVUnKCT1kIFKzF9TfHHHHkJXTH4bomJizgUt7mbiDnEeVfmOcXscpPCEvbAckPFr5noolgXvM3jye8kEt0Fut9_aZnSXW7G2Y8FL5s-ED8XTwY_Mr04vqfi-4f315efyqsvHz9frq_KTqM1pYYWe-1qtENvtFfUVUZabPva67wZkfeItraVQqDeE8mqVY689eAGjYM6FW8PunmP3xvipZkCdzSOfqa44cZpCwZVVWXyzT9JW4Ny6OC_oARltJMug-8OYJcic6KhuU1h8mnbIDS7uJp8yGYfV2ZfHUU37UT9A3nMJwOvj4Dnzo9D8nMX-IGrDNbW7oTOD9x9GGn7d8dm_e36YP0HVtSs6Q</recordid><startdate>20070215</startdate><enddate>20070215</enddate><creator>Belo, J. N.</creator><creator>Berger, M. Y.</creator><creator>Reijman, M.</creator><creator>Koes, B. W.</creator><creator>Bierma‐Zeinstra, S. M. A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070215</creationdate><title>Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies</title><author>Belo, J. N. ; Berger, M. Y. ; Reijman, M. ; Koes, B. W. ; Bierma‐Zeinstra, S. M. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4165-40b1d47916fd54a3ec85261bd9a4131eeaa116968310edaee28b37ea6a07f41f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Hyaluronic Acid - blood</topic><topic>Knee</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - blood</topic><topic>Osteoarthritis, Knee - diagnostic imaging</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Progression</topic><topic>Radiography</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belo, J. N.</creatorcontrib><creatorcontrib>Berger, M. Y.</creatorcontrib><creatorcontrib>Reijman, M.</creatorcontrib><creatorcontrib>Koes, B. W.</creatorcontrib><creatorcontrib>Bierma‐Zeinstra, S. M. A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belo, J. N.</au><au>Berger, M. Y.</au><au>Reijman, M.</au><au>Koes, B. W.</au><au>Bierma‐Zeinstra, S. M. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>2007-02-15</date><risdate>2007</risdate><volume>57</volume><issue>1</issue><spage>13</spage><epage>26</epage><pages>13-26</pages><issn>0004-3591</issn><issn>0893-7524</issn><eissn>1529-0131</eissn><eissn>1529-0123</eissn><coden>ARCREG</coden><abstract>Objective
To provide an overview of prognostic factors of knee osteoarthritis (OA) progression.
Methods
We searched Medline and Embase up to December 2003 according to a specified search strategy (keywords for disease, location, and study design). Studies that fulfilled predefined criteria were assessed for methodologic quality. Study characteristics and associations were extracted and the results were summarized according to a best evidence synthesis.
Results
Of the 1,004 studies found, 37 met the inclusion criteria. Methodologic quality was assessed and only high‐quality studies were included (n = 36). The best evidence synthesis yielded strong evidence that hyaluronic acid serum levels and generalized OA are predictive for progression of knee OA. Sex, knee pain, radiologic severity, knee injury, quadriceps strength, and regular sport activities were not predictive. Conflicting evidence for associations was found for several factors including body mass index and age. Limited evidence for an association with progression of knee OA was found for several factors, including the alignment (varus/valgus) of the joint. Limited evidence for no association with progression of OA was also found for several factors, including meniscectomy, several markers of bone or cartilage turnover, and the clinical diagnosis of localized OA.
Conclusion
Generalized OA and level of hyaluronic acid seem to be associated with the radiologic progression of knee OA. Knee pain, radiologic severity at baseline, sex, quadriceps strength, knee injury, and regular sport activities seem not to be related. For other factors, the evidence was limited or conflicting.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17266080</pmid><doi>10.1002/art.22475</doi><tpages>14</tpages></addata></record> |
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| ispartof | Arthritis and rheumatism, 2007-02, Vol.57 (1), p.13-26 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Disease Progression Diseases of the osteoarticular system Female Humans Hyaluronic Acid - blood Knee Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis, Knee - blood Osteoarthritis, Knee - diagnostic imaging Osteoarthritis, Knee - physiopathology Predictive Value of Tests Prognosis Prognostic factors Progression Radiography Systematic review |
| title | Prognostic factors of progression of osteoarthritis of the knee: A systematic review of observational studies |
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