Some effects of chemotherapeutic drugs on bone marrow stem cells. II. Effect on non-Hodgkin lymphoma chemotherapy on various hemopoietic compartments of the mouse
The non-Hodgkin lymphoma chemotherapy protocol used at the Gustave-Roussy Institute was adapted, in terms of drug doses and interval between doses, to normal CBA mice. The numbers of pluripotential stem cells (CFU-S), unipotential stem cells (CFC), differentiated bone marrow cells, and circulating w...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1979, Vol.2 (3), p.203-207 |
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| container_title | Cancer chemotherapy and pharmacology |
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| creator | Duménil, D Sainteny, F Frindel, E |
| description | The non-Hodgkin lymphoma chemotherapy protocol used at the Gustave-Roussy Institute was adapted, in terms of drug doses and interval between doses, to normal CBA mice. The numbers of pluripotential stem cells (CFU-S), unipotential stem cells (CFC), differentiated bone marrow cells, and circulating white cells were determined. Eight hours after each drug of the first chemotherapy cycle the number of pluripotent stem cells decreased while the proportion of these cells in DNA synthesis increased. Six hours after the end of each complete cycle, the stem cell compartments were found to be considerably depleted, and they were not completely restored when the next cycle was begun, while the other hematologic compartments were completely restored at this time. |
| doi_str_mv | 10.1007/BF00258296 |
| format | Article |
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Six hours after the end of each complete cycle, the stem cell compartments were found to be considerably depleted, and they were not completely restored when the next cycle was begun, while the other hematologic compartments were completely restored at this time.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00258296</identifier><identifier>PMID: 455576</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - pharmacology ; Bone Marrow - drug effects ; Bone Marrow Diseases - drug therapy ; Colony-Forming Units Assay ; Doxorubicin - administration & dosage ; Doxorubicin - pharmacology ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Hematopoietic Stem Cells - drug effects ; Leukocyte Count ; Lymphoma - drug therapy ; Male ; Methylprednisolone - administration & dosage ; Methylprednisolone - pharmacology ; Mice ; Mice, Inbred CBA ; Models, Biological ; Prednisone - administration & dosage ; Prednisone - pharmacology ; Teniposide - administration & dosage ; Teniposide - pharmacology</subject><ispartof>Cancer chemotherapy and pharmacology, 1979, Vol.2 (3), p.203-207</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c155t-e7d3f9186cb3bbee908f1ea144b3b7eaeb572ca26da19eec3a9a000054d1a36d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/455576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duménil, D</creatorcontrib><creatorcontrib>Sainteny, F</creatorcontrib><creatorcontrib>Frindel, E</creatorcontrib><title>Some effects of chemotherapeutic drugs on bone marrow stem cells. II. Effect on non-Hodgkin lymphoma chemotherapy on various hemopoietic compartments of the mouse</title><title>Cancer chemotherapy and pharmacology</title><addtitle>Cancer Chemother Pharmacol</addtitle><description>The non-Hodgkin lymphoma chemotherapy protocol used at the Gustave-Roussy Institute was adapted, in terms of drug doses and interval between doses, to normal CBA mice. The numbers of pluripotential stem cells (CFU-S), unipotential stem cells (CFC), differentiated bone marrow cells, and circulating white cells were determined. Eight hours after each drug of the first chemotherapy cycle the number of pluripotent stem cells decreased while the proportion of these cells in DNA synthesis increased. Six hours after the end of each complete cycle, the stem cell compartments were found to be considerably depleted, and they were not completely restored when the next cycle was begun, while the other hematologic compartments were completely restored at this time.</description><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Bone Marrow - drug effects</subject><subject>Bone Marrow Diseases - drug therapy</subject><subject>Colony-Forming Units Assay</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Leukocyte Count</subject><subject>Lymphoma - drug therapy</subject><subject>Male</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Models, Biological</subject><subject>Prednisone - administration & dosage</subject><subject>Prednisone - pharmacology</subject><subject>Teniposide - administration & dosage</subject><subject>Teniposide - pharmacology</subject><issn>0344-5704</issn><issn>1432-0843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkT1PwzAQhi3EVykszAyeGJBS7NhOmhGqllaqxADMkeNc2kAcBzsB9e_wS3FIBUynu3v03seL0CUlE0pIfHu_ICQU0zCJDtCIchYGZMrZIRoRxnkgYsJP0Zlzr4QQThk7QcdcCBFHI_T1ZDRgKApQrcOmwGoL2rRbsLKBri0Vzm238Z0aZ6YGrKW15hO7FjRWUFVuglerCZ7_CPRUbepgafLNW1njaqebrdHyv-iuhz6kLU3ncF9uTAn9HGV0I22roR4W8TjWHoJzdFTIysHFPo7Ry2L-PFsG68eH1exuHSgqRBtAnLMiodNIZSzLABIyLShIyrnPY5CQiThUMoxySRMAxWQi_T-I4DmVLMrZGF0Puo017x24NtWl62-UNfg90phHhDNGPXgzgMoa5ywUaWNL_5hdSkna-5H--eHhq71ql2nIf9HBAPYNK2WJGw</recordid><startdate>1979</startdate><enddate>1979</enddate><creator>Duménil, D</creator><creator>Sainteny, F</creator><creator>Frindel, E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1979</creationdate><title>Some effects of chemotherapeutic drugs on bone marrow stem cells. 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Effect on non-Hodgkin lymphoma chemotherapy on various hemopoietic compartments of the mouse</title><author>Duménil, D ; Sainteny, F ; Frindel, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c155t-e7d3f9186cb3bbee908f1ea144b3b7eaeb572ca26da19eec3a9a000054d1a36d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Bone Marrow - drug effects</topic><topic>Bone Marrow Diseases - drug therapy</topic><topic>Colony-Forming Units Assay</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Leukocyte Count</topic><topic>Lymphoma - drug therapy</topic><topic>Male</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Models, Biological</topic><topic>Prednisone - administration & dosage</topic><topic>Prednisone - pharmacology</topic><topic>Teniposide - administration & dosage</topic><topic>Teniposide - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duménil, D</creatorcontrib><creatorcontrib>Sainteny, F</creatorcontrib><creatorcontrib>Frindel, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duménil, D</au><au>Sainteny, F</au><au>Frindel, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Some effects of chemotherapeutic drugs on bone marrow stem cells. II. Effect on non-Hodgkin lymphoma chemotherapy on various hemopoietic compartments of the mouse</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1979</date><risdate>1979</risdate><volume>2</volume><issue>3</issue><spage>203</spage><epage>207</epage><pages>203-207</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><abstract>The non-Hodgkin lymphoma chemotherapy protocol used at the Gustave-Roussy Institute was adapted, in terms of drug doses and interval between doses, to normal CBA mice. The numbers of pluripotential stem cells (CFU-S), unipotential stem cells (CFC), differentiated bone marrow cells, and circulating white cells were determined. Eight hours after each drug of the first chemotherapy cycle the number of pluripotent stem cells decreased while the proportion of these cells in DNA synthesis increased. 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| ispartof | Cancer chemotherapy and pharmacology, 1979, Vol.2 (3), p.203-207 |
| issn | 0344-5704 1432-0843 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Bone Marrow - drug effects Bone Marrow Diseases - drug therapy Colony-Forming Units Assay Doxorubicin - administration & dosage Doxorubicin - pharmacology Drug Administration Schedule Drug Therapy, Combination Female Hematopoietic Stem Cells - drug effects Leukocyte Count Lymphoma - drug therapy Male Methylprednisolone - administration & dosage Methylprednisolone - pharmacology Mice Mice, Inbred CBA Models, Biological Prednisone - administration & dosage Prednisone - pharmacology Teniposide - administration & dosage Teniposide - pharmacology |
| title | Some effects of chemotherapeutic drugs on bone marrow stem cells. II. Effect on non-Hodgkin lymphoma chemotherapy on various hemopoietic compartments of the mouse |
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