IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides
Bacterial lipopolysaccharides (LPS) induced the formation of IgM rheumatoid factors (RF) in several strains of mice including athymic C57BL/6 nude mice, but not in the LPS-resistant C3H/HeJ mice. The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs,...
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| Veröffentlicht in: | The Journal of immunology (1950) 1979-05, Vol.122 (5), p.2096-2102 |
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| container_end_page | 2102 |
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| container_issue | 5 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 122 |
| creator | Izui, Shozo Eisenberg, Robert A Dixon, Frank J |
| description | Bacterial lipopolysaccharides (LPS) induced the formation of IgM rheumatoid factors (RF) in several strains of mice including athymic C57BL/6 nude mice, but not in the LPS-resistant C3H/HeJ mice. The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs, and humans. The kinetics of this RF response to injection of LPS were similar to those of antibody response against DNA and a hapten, dinitrophenyl (DNP), and to those of total IgM production. In addition, the RF activity of individual serum samples correlated significantly with levels of anti-DNA and anti-DNP antibodies and of IgM. Therefore, it is concluded that the induction of RF results from polyclonal antibody synthesis by B cells stimulated with LPS. This observation suggests that LPS or LPS-like substances may help to generate RF in patients with rheumatoid arthritis or with some infectious diseases. |
| doi_str_mv | 10.4049/jimmunol.122.5.2096 |
| format | Article |
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The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs, and humans. The kinetics of this RF response to injection of LPS were similar to those of antibody response against DNA and a hapten, dinitrophenyl (DNP), and to those of total IgM production. In addition, the RF activity of individual serum samples correlated significantly with levels of anti-DNA and anti-DNP antibodies and of IgM. Therefore, it is concluded that the induction of RF results from polyclonal antibody synthesis by B cells stimulated with LPS. This observation suggests that LPS or LPS-like substances may help to generate RF in patients with rheumatoid arthritis or with some infectious diseases.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.122.5.2096</identifier><identifier>PMID: 376732</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Antibodies ; Antibody Specificity ; Cattle ; Dinitrobenzenes - immunology ; DNA, Single-Stranded - immunology ; Dose-Response Relationship, Immunologic ; Female ; Goats ; Guinea Pigs ; Humans ; Immunoglobulin M ; Lipopolysaccharides - pharmacology ; Mercaptoethanol - pharmacology ; Mice ; Mice, Inbred AKR ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred C57BL ; Mice, Nude ; Rheumatoid Factor ; Salmonella typhimurium - immunology</subject><ispartof>The Journal of immunology (1950), 1979-05, Vol.122 (5), p.2096-2102</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-e5ff251db5df74b64ea7cabf0b5524368b02edc6163b3843750ade6b0ec0601c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/376732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izui, Shozo</creatorcontrib><creatorcontrib>Eisenberg, Robert A</creatorcontrib><creatorcontrib>Dixon, Frank J</creatorcontrib><title>IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Bacterial lipopolysaccharides (LPS) induced the formation of IgM rheumatoid factors (RF) in several strains of mice including athymic C57BL/6 nude mice, but not in the LPS-resistant C3H/HeJ mice. The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs, and humans. The kinetics of this RF response to injection of LPS were similar to those of antibody response against DNA and a hapten, dinitrophenyl (DNP), and to those of total IgM production. In addition, the RF activity of individual serum samples correlated significantly with levels of anti-DNA and anti-DNP antibodies and of IgM. Therefore, it is concluded that the induction of RF results from polyclonal antibody synthesis by B cells stimulated with LPS. This observation suggests that LPS or LPS-like substances may help to generate RF in patients with rheumatoid arthritis or with some infectious diseases.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibody Specificity</subject><subject>Cattle</subject><subject>Dinitrobenzenes - immunology</subject><subject>DNA, Single-Stranded - immunology</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Female</subject><subject>Goats</subject><subject>Guinea Pigs</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Mercaptoethanol - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred AKR</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Nude</subject><subject>Rheumatoid Factor</subject><subject>Salmonella typhimurium - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC3EXyk8ARxyglOC7cROOUJFoagVEoKz5TibxlUSBztR1LfHVQritNLO7Ozuh9A1wVGCk4f7ra7rvjFVRCiNWETxAz9CE8IYDjnH_BhNMKY0JClPz9GFc1uMMcc0OUOnse_FdILelpt18FFCX8vO6DxYSNUZ6wLdBGutIFg2W1Ad5MGguzJ48ipYLatgpVvTmmrnpFKltDoHd4lOClk5uDrUKfpaPH_OX8PV-8ty_rgKlV_ahcCKgjKSZywv0iTjCchUyazAGWM0ifkswxRyxQmPs3iWxCnDMgeeYVD-eKLiKbodc1trvntwnai1U1BVsgHTO5Em_keaUm-MR6OyxjkLhWitrqXdCYLFHqD4BSg8QMHEHqCfujnE91kN-d_MSMzLd6Nc6k05aAvC1bKqvJmIYRj-Bf0AGwR8NQ</recordid><startdate>197905</startdate><enddate>197905</enddate><creator>Izui, Shozo</creator><creator>Eisenberg, Robert A</creator><creator>Dixon, Frank J</creator><general>Am Assoc Immnol</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197905</creationdate><title>IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides</title><author>Izui, Shozo ; Eisenberg, Robert A ; Dixon, Frank J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-e5ff251db5df74b64ea7cabf0b5524368b02edc6163b3843750ade6b0ec0601c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibody Specificity</topic><topic>Cattle</topic><topic>Dinitrobenzenes - immunology</topic><topic>DNA, Single-Stranded - immunology</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Female</topic><topic>Goats</topic><topic>Guinea Pigs</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Mercaptoethanol - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred AKR</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Nude</topic><topic>Rheumatoid Factor</topic><topic>Salmonella typhimurium - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izui, Shozo</creatorcontrib><creatorcontrib>Eisenberg, Robert A</creatorcontrib><creatorcontrib>Dixon, Frank J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izui, Shozo</au><au>Eisenberg, Robert A</au><au>Dixon, Frank J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1979-05</date><risdate>1979</risdate><volume>122</volume><issue>5</issue><spage>2096</spage><epage>2102</epage><pages>2096-2102</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Bacterial lipopolysaccharides (LPS) induced the formation of IgM rheumatoid factors (RF) in several strains of mice including athymic C57BL/6 nude mice, but not in the LPS-resistant C3H/HeJ mice. The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs, and humans. The kinetics of this RF response to injection of LPS were similar to those of antibody response against DNA and a hapten, dinitrophenyl (DNP), and to those of total IgM production. In addition, the RF activity of individual serum samples correlated significantly with levels of anti-DNA and anti-DNP antibodies and of IgM. Therefore, it is concluded that the induction of RF results from polyclonal antibody synthesis by B cells stimulated with LPS. This observation suggests that LPS or LPS-like substances may help to generate RF in patients with rheumatoid arthritis or with some infectious diseases.</abstract><cop>United States</cop><pub>Am Assoc Immnol</pub><pmid>376732</pmid><doi>10.4049/jimmunol.122.5.2096</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibodies Antibody Specificity Cattle Dinitrobenzenes - immunology DNA, Single-Stranded - immunology Dose-Response Relationship, Immunologic Female Goats Guinea Pigs Humans Immunoglobulin M Lipopolysaccharides - pharmacology Mercaptoethanol - pharmacology Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Nude Rheumatoid Factor Salmonella typhimurium - immunology |
| title | IgM Rheumatoid Factors in Mice Injected with Bacterial Lipopolysaccharides |
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