Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis

In mammals, the gastrointestinal tract harbors an extraordinarily dense and complex community of microorganisms. The gut microbiota provide strong selective pressure to the host to evolve adaptive immune responses required for the maintenance of local and systemic homeostasis. The continuous antigen...

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Veröffentlicht in:	Annual review of immunology 2010-01, Vol.28 (1), p.243-273
Hauptverfasser:	Fagarasan, Sidonia, Kawamoto, Shimpei, Kanagawa, Osami, Suzuki, Keiichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Animals Antibody Formation Gastrointestinal Tract - immunology Homeostasis Humans Immunoglobulin A - biosynthesis Immunoglobulin A - immunology T-Lymphocytes - immunology
Online-Zugang:	Volltext
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