Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84

CD4 + T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-02, Vol.32 (2), p.253-265
Hauptverfasser:	Cannons, Jennifer L., Qi, Hai, Lu, Kristina T., Dutta, Mala, Gomez-Rodriguez, Julio, Cheng, Jun, Wakeland, Edward K., Germain, Ronald N., Schwartzberg, Pamela L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Antigens, Ly - immunology Antigens, Ly - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Cell Adhesion - genetics Cell Adhesion - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Proliferation Cells, Cultured Flow cytometry Germinal Center - metabolism Germinal Center - pathology Immune system Interferon-gamma - secretion Interleukins - secretion Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism Ligands Lymphocyte Activation - genetics Mice Mice, Inbred C57BL Mice, Knockout MOLIMMUNO Proteins Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Rodents Signaling Lymphocytic Activation Molecule Associated Protein Signaling Lymphocytic Activation Molecule Family Signaling Lymphocytic Activation Molecule Family Member 1 Software T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology
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