From allergen genes to allergy vaccines
IgE-mediated allergy is a hypersensitivity disease affecting more than 25% of the population. The structures of the most common allergens have been revealed through molecular cloning technology in the past two decades. On the basis of this knowledge of the sequences and three-dimensional structures...
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| Veröffentlicht in: | Annual review of immunology 2010-01, Vol.28 (1), p.211-241 |
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| container_end_page | 241 |
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| container_title | Annual review of immunology |
| container_volume | 28 |
| creator | Valenta, Rudolf Ferreira, Fatima Focke-Tejkl, Margarete Linhart, Birgit Niederberger, Verena Swoboda, Ines Vrtala, Susanne |
| description | IgE-mediated allergy is a hypersensitivity disease affecting more than 25% of the population. The structures of the most common allergens have been revealed through molecular cloning technology in the past two decades. On the basis of this knowledge of the sequences and three-dimensional structures of culprit allergens, investigators can now analyze the immune recognition of allergens and the mechanisms of allergic inflammation in allergic patients. Allergy vaccines have been constructed that are able to selectively target the aberrant immune responses in allergic patients via different pathways of the immune system. Here we review various types of allergy vaccines that have been developed based on allergen structures, results from their clinical application in allergic patients, and future strategies for allergen-specific immunotherapy and allergy prophylaxis. |
| doi_str_mv | 10.1146/annurev-immunol-030409-101218 |
| format | Article |
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| ispartof | Annual review of immunology, 2010-01, Vol.28 (1), p.211-241 |
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| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Allergens - chemistry Allergens - genetics Allergens - immunology Animals Humans Hypersensitivity - immunology Hypersensitivity - prevention & control Hypersensitivity - therapy Immunoglobulin E - immunology Immunotherapy Vaccines - immunology |
| title | From allergen genes to allergy vaccines |
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