Thousands of chemical starting points for antimalarial lead identification

Malaria is a devastating infection caused by protozoa of the genus Plasmodium . Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 1996 and there is a recent rise of parasite strains with reduced sensitivity to the newest drugs. We...

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Veröffentlicht in:	Nature (London) 2010-05, Vol.465 (7296), p.305-310
Hauptverfasser:	Gamo, Francisco-Javier, Sanz, Laura M., Vidal, Jaume, de Cozar, Cristina, Alvarez, Emilio, Lavandera, Jose-Luis, Vanderwall, Dana E., Green, Darren V. S., Kumar, Vinod, Hasan, Samiul, Brown, James R., Peishoff, Catherine E., Cardon, Lon R., Garcia-Bustos, Jose F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/555 631/326/22/1294 631/326/417 Animals Antimalarials Antimalarials - analysis Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - toxicity Biological and medical sciences Causes of Cell Line, Tumor Clinical medicine Communities Drug Discovery Drug resistance Drug Resistance, Multiple - drug effects Drug therapy Drugs General aspects Health aspects Human protozoal diseases Humanities and Social Sciences Humans Infectious diseases Inhibitors Kinases Malaria Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Medical sciences Models, Biological Mortality multidisciplinary Parasites Parasitic diseases Phylogeny Plasmodium Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - enzymology Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Protozoa Protozoal diseases Science Science (multidisciplinary) Small Molecule Libraries - analysis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Small Molecule Libraries - toxicity Software packages Strain Vector-borne diseases
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