Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy

Membrane proteins pose a huge challenge for structural analysis, but a new study reports the first NMR structure determination of a detergent-solubilized seven-helical transmembrane (7TM) protein, the phototaxis receptor sensory rhodopsin II. This case study may open the doors to similar solution NM...

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Veröffentlicht in:	Nature Structural & Molecular Biology 2010-06, Vol.17 (6), p.768-774
Hauptverfasser:	Nietlispach, Daniel, Mott, Helen R, Gautier, Antoine, Bostock, Mark J, Kirkpatrick, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2258 631/45/535/878 Biochemistry Biological Microscopy Biomedical and Life Sciences Case studies Cell receptors Detergents Halobacteriaceae - chemistry Halorhodopsins - chemistry Hydrophobic and Hydrophilic Interactions Life Sciences Membrane Biology Membrane proteins Membranes Micelles Models, Molecular Molecular biology Molecular structure NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Physiological aspects Protein Stability Protein Structure Protein Structure, Secondary Proteins Receptors, G-Protein-Coupled - chemistry Rhodopsin Sensory Rhodopsins - chemistry Solubility Structure technical-report Thermodynamics
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