Sepsis in acute myeloid leukaemia patients receiving high-dose chemotherapy: No impact of chitotriosidase and mannose-binding lectin polymorphisms

Infections after chemotherapy often cause significant morbidity in patients with acute myeloid leukaemia (AML). Chitotriosidase (CHIT) and mannose‐binding lectin (MBL) are part of the innate immune system. Polymorphism in the CHIT‐coding gene (CHIT1) may be associated with Gram‐negative sepsis in ch...

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Veröffentlicht in:	European journal of haematology 2010-07, Vol.85 (1), p.58-64
Hauptverfasser:	Klostergaard, Anja, Steffensen, Rudi, Møller, Jens K., Peterslund, Niels, Juhl-Christensen, Caroline, Mølle, Ingolf
Format:	Artikel
Sprache:	eng
Schlagworte:	acute leukaemia acute myeloid leukaemia Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols CHIT-coding gene chitotriosidase Female Genetic Predisposition to Disease Gram-Negative Bacterial Infections - etiology Gram-Negative Bacterial Infections - genetics Gram-Negative Bacterial Infections - immunology Gram-Positive Bacterial Infections - etiology Gram-Positive Bacterial Infections - genetics Gram-Positive Bacterial Infections - immunology Hexosaminidases - genetics Hexosaminidases - immunology Humans Immunity, Innate - genetics infection innate immune system Leukemia, Myeloid, Acute - complications Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Male mannose-binding lectin Mannose-Binding Lectin - genetics Mannose-Binding Lectin - pharmacology MBL-coding gene Middle Aged polymorphism Polymorphism, Genetic Recombinant Proteins - pharmacology Risk Factors Sepsis - etiology Sepsis - genetics Sepsis - immunology Sepsis - prevention & control Young Adult
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