Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis
To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS. Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tert...
Gespeichert in:
Veröffentlicht in: | AIDS (London) 2010-06, Vol.24 (9), p.1299-1306 |
---|---|
Hauptverfasser: | , , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1306 |
---|---|
container_issue | 9 |
container_start_page | 1299 |
container_title | AIDS (London) |
container_volume | 24 |
creator | FARDET, Laurence LAMBOTTE, Olivier MOLINA, Jean-Michel MARTINEZ, Valérie MEYNARD, Jean-Luc KAMOUH, Wassim GALICIER, Lionel MARZAC, Christophe DE LABARTHE, Adrienne CABANE, Jean LEBBE, Céleste COPPO, Paul |
description | To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS.
Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tertiary centres.
Medical charts of HIV-1-infected adult patients and RHS seen between January 2006 and December 2007 were reviewed. Demographic, clinical and laboratory data obtained at the time of RHS episode were compared between patients with malignancy-associated RHS and infection-associated RHS using non-parametric tests. The overall survival was assessed using the Kaplan-Meier method.
Fifty-eight HIV-1-infected patients were diagnosed with RHS [certain RHS n = 43, possible RHS n = 15, median (range) age 42 (23-85) years, men 76%]. At time of RHS, the median duration of HIV infection was 4 (0-22) years and 57% received HAART. The median CD4 lymphocyte count was 91 (2-387)/microl and 35% of patients had a plasma HIV-1 RNA less than 50 copies/ml. Underlying haemopathy/malignancy (Hodgkin lymphoma n = 10) or infection (tuberculosis n = 9, cytomegalovirus infection n = 5) were evidenced for 31 and 23 patients, respectively. Patients with haemopathy/malignancy-associated RHS presented more frequently with splenomegaly (97 vs. 70%, P < 0.01), lower aspartate aminotransferase (36 vs. 84 UI/l, P < 0.01) and lactate dehydrogenase (530 vs. 911 UI/l, P < 0.01) levels and CD8 cell count (234 vs. 588/microl, P < 0.01). Eighteen (31%) patients died. The overall survival was not statistically different between the two groups (P = 0.68).
In the HAART era, RHS is frequently associated with underlying haemopathy/malignancy, especially Hodgkin lymphoma. The prognosis remains poor but seems, however, better than in the pre-HAART era. |
doi_str_mv | 10.1097/qad.0b013e328339e55b |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_746010363</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733302497</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-3c0f03bf6cd7da49ae1204358396cce92846a21911cb7f87f059d8da841d3ba3</originalsourceid><addsrcrecordid>eNqFkU1rFTEUhoNY7LX6D0SyETdOezJJJom7Uj9aKBSluB3OJCe3kZnM7WSmcP-9U3pVcOPqbJ7nvPC-jL0RcCrAmbN7DKfQgZAkayulI627Z2wjlJGV1kY8ZxuoG1c5aeCYvSzlJwBosPYFO65Bawey2bDlO6Gf0wPxO6Rh3N3hdvT7OXle9jlM40A8Za4tv7z6UYkq5Uh-psB3OCfKc_nIfZ9y8tjzSDgvE5UPfMmBpn6f8paHVAgLFY55laZxm8eSyit2FLEv9PpwT9jtl8-3F5fV9c3Xq4vz68orC3MlPUSQXWx8MAGVQxI1KKmtdI335GqrGqyFE8J3JloTQbtgA1olguxQnrD3T2_X4PuFytwOqXjqe8w0LqU1qgGx1iD_T0opoVbOrKR6Iv00ljJRbHdTGnDatwLax2Hab-ef2n-HWbW3h4ClGyj8kX4vsQLvDgCWtc04Yfap_OVqa6xRTv4CWwGYew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733302497</pqid></control><display><type>article</type><title>Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>FARDET, Laurence ; LAMBOTTE, Olivier ; MOLINA, Jean-Michel ; MARTINEZ, Valérie ; MEYNARD, Jean-Luc ; KAMOUH, Wassim ; GALICIER, Lionel ; MARZAC, Christophe ; DE LABARTHE, Adrienne ; CABANE, Jean ; LEBBE, Céleste ; COPPO, Paul</creator><creatorcontrib>FARDET, Laurence ; LAMBOTTE, Olivier ; MOLINA, Jean-Michel ; MARTINEZ, Valérie ; MEYNARD, Jean-Luc ; KAMOUH, Wassim ; GALICIER, Lionel ; MARZAC, Christophe ; DE LABARTHE, Adrienne ; CABANE, Jean ; LEBBE, Céleste ; COPPO, Paul</creatorcontrib><description>To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS.
Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tertiary centres.
Medical charts of HIV-1-infected adult patients and RHS seen between January 2006 and December 2007 were reviewed. Demographic, clinical and laboratory data obtained at the time of RHS episode were compared between patients with malignancy-associated RHS and infection-associated RHS using non-parametric tests. The overall survival was assessed using the Kaplan-Meier method.
Fifty-eight HIV-1-infected patients were diagnosed with RHS [certain RHS n = 43, possible RHS n = 15, median (range) age 42 (23-85) years, men 76%]. At time of RHS, the median duration of HIV infection was 4 (0-22) years and 57% received HAART. The median CD4 lymphocyte count was 91 (2-387)/microl and 35% of patients had a plasma HIV-1 RNA less than 50 copies/ml. Underlying haemopathy/malignancy (Hodgkin lymphoma n = 10) or infection (tuberculosis n = 9, cytomegalovirus infection n = 5) were evidenced for 31 and 23 patients, respectively. Patients with haemopathy/malignancy-associated RHS presented more frequently with splenomegaly (97 vs. 70%, P < 0.01), lower aspartate aminotransferase (36 vs. 84 UI/l, P < 0.01) and lactate dehydrogenase (530 vs. 911 UI/l, P < 0.01) levels and CD8 cell count (234 vs. 588/microl, P < 0.01). Eighteen (31%) patients died. The overall survival was not statistically different between the two groups (P = 0.68).
In the HAART era, RHS is frequently associated with underlying haemopathy/malignancy, especially Hodgkin lymphoma. The prognosis remains poor but seems, however, better than in the pre-HAART era.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/qad.0b013e328339e55b</identifier><identifier>PMID: 20559036</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; AIDS-Related Opportunistic Infections - mortality ; AIDS-Related Opportunistic Infections - virology ; AIDS/HIV ; Antiretroviral Therapy, Highly Active ; Aspartate aminotransferase ; Biological and medical sciences ; CD4 antigen ; CD4 Lymphocyte Count ; CD8 antigen ; Cell number ; Cytomegalovirus ; Data processing ; Demography ; Female ; France ; Hematologic and hematopoietic diseases ; highly active antiretroviral therapy ; HIV Infections - complications ; HIV Infections - drug therapy ; HIV Infections - mortality ; HIV-1 - immunology ; Hodgkin's disease ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infection ; Infectious diseases ; Kaplan-Meier Estimate ; L-Lactate dehydrogenase ; Lymphohistiocytosis, Hemophagocytic - complications ; Lymphohistiocytosis, Hemophagocytic - mortality ; Lymphohistiocytosis, Hemophagocytic - virology ; Male ; Malignancy ; Medical sciences ; Middle Aged ; Mycobacterium ; Other diseases. Hematologic involvement in other diseases ; Prognosis ; Retrospective Studies ; RNA ; Splenomegaly ; Survival ; Tuberculosis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>AIDS (London), 2010-06, Vol.24 (9), p.1299-1306</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-3c0f03bf6cd7da49ae1204358396cce92846a21911cb7f87f059d8da841d3ba3</citedby><cites>FETCH-LOGICAL-c480t-3c0f03bf6cd7da49ae1204358396cce92846a21911cb7f87f059d8da841d3ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22878749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20559036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FARDET, Laurence</creatorcontrib><creatorcontrib>LAMBOTTE, Olivier</creatorcontrib><creatorcontrib>MOLINA, Jean-Michel</creatorcontrib><creatorcontrib>MARTINEZ, Valérie</creatorcontrib><creatorcontrib>MEYNARD, Jean-Luc</creatorcontrib><creatorcontrib>KAMOUH, Wassim</creatorcontrib><creatorcontrib>GALICIER, Lionel</creatorcontrib><creatorcontrib>MARZAC, Christophe</creatorcontrib><creatorcontrib>DE LABARTHE, Adrienne</creatorcontrib><creatorcontrib>CABANE, Jean</creatorcontrib><creatorcontrib>LEBBE, Céleste</creatorcontrib><creatorcontrib>COPPO, Paul</creatorcontrib><title>Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS.
Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tertiary centres.
Medical charts of HIV-1-infected adult patients and RHS seen between January 2006 and December 2007 were reviewed. Demographic, clinical and laboratory data obtained at the time of RHS episode were compared between patients with malignancy-associated RHS and infection-associated RHS using non-parametric tests. The overall survival was assessed using the Kaplan-Meier method.
Fifty-eight HIV-1-infected patients were diagnosed with RHS [certain RHS n = 43, possible RHS n = 15, median (range) age 42 (23-85) years, men 76%]. At time of RHS, the median duration of HIV infection was 4 (0-22) years and 57% received HAART. The median CD4 lymphocyte count was 91 (2-387)/microl and 35% of patients had a plasma HIV-1 RNA less than 50 copies/ml. Underlying haemopathy/malignancy (Hodgkin lymphoma n = 10) or infection (tuberculosis n = 9, cytomegalovirus infection n = 5) were evidenced for 31 and 23 patients, respectively. Patients with haemopathy/malignancy-associated RHS presented more frequently with splenomegaly (97 vs. 70%, P < 0.01), lower aspartate aminotransferase (36 vs. 84 UI/l, P < 0.01) and lactate dehydrogenase (530 vs. 911 UI/l, P < 0.01) levels and CD8 cell count (234 vs. 588/microl, P < 0.01). Eighteen (31%) patients died. The overall survival was not statistically different between the two groups (P = 0.68).
In the HAART era, RHS is frequently associated with underlying haemopathy/malignancy, especially Hodgkin lymphoma. The prognosis remains poor but seems, however, better than in the pre-HAART era.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIDS-Related Opportunistic Infections - mortality</subject><subject>AIDS-Related Opportunistic Infections - virology</subject><subject>AIDS/HIV</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Aspartate aminotransferase</subject><subject>Biological and medical sciences</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>CD8 antigen</subject><subject>Cell number</subject><subject>Cytomegalovirus</subject><subject>Data processing</subject><subject>Demography</subject><subject>Female</subject><subject>France</subject><subject>Hematologic and hematopoietic diseases</subject><subject>highly active antiretroviral therapy</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - mortality</subject><subject>HIV-1 - immunology</subject><subject>Hodgkin's disease</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Kaplan-Meier Estimate</subject><subject>L-Lactate dehydrogenase</subject><subject>Lymphohistiocytosis, Hemophagocytic - complications</subject><subject>Lymphohistiocytosis, Hemophagocytic - mortality</subject><subject>Lymphohistiocytosis, Hemophagocytic - virology</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Other diseases. Hematologic involvement in other diseases</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>RNA</subject><subject>Splenomegaly</subject><subject>Survival</subject><subject>Tuberculosis</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Young Adult</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoNY7LX6D0SyETdOezJJJom7Uj9aKBSluB3OJCe3kZnM7WSmcP-9U3pVcOPqbJ7nvPC-jL0RcCrAmbN7DKfQgZAkayulI627Z2wjlJGV1kY8ZxuoG1c5aeCYvSzlJwBosPYFO65Bawey2bDlO6Gf0wPxO6Rh3N3hdvT7OXle9jlM40A8Za4tv7z6UYkq5Uh-psB3OCfKc_nIfZ9y8tjzSDgvE5UPfMmBpn6f8paHVAgLFY55laZxm8eSyit2FLEv9PpwT9jtl8-3F5fV9c3Xq4vz68orC3MlPUSQXWx8MAGVQxI1KKmtdI335GqrGqyFE8J3JloTQbtgA1olguxQnrD3T2_X4PuFytwOqXjqe8w0LqU1qgGx1iD_T0opoVbOrKR6Iv00ljJRbHdTGnDatwLax2Hab-ef2n-HWbW3h4ClGyj8kX4vsQLvDgCWtc04Yfap_OVqa6xRTv4CWwGYew</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>FARDET, Laurence</creator><creator>LAMBOTTE, Olivier</creator><creator>MOLINA, Jean-Michel</creator><creator>MARTINEZ, Valérie</creator><creator>MEYNARD, Jean-Luc</creator><creator>KAMOUH, Wassim</creator><creator>GALICIER, Lionel</creator><creator>MARZAC, Christophe</creator><creator>DE LABARTHE, Adrienne</creator><creator>CABANE, Jean</creator><creator>LEBBE, Céleste</creator><creator>COPPO, Paul</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20100601</creationdate><title>Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis</title><author>FARDET, Laurence ; LAMBOTTE, Olivier ; MOLINA, Jean-Michel ; MARTINEZ, Valérie ; MEYNARD, Jean-Luc ; KAMOUH, Wassim ; GALICIER, Lionel ; MARZAC, Christophe ; DE LABARTHE, Adrienne ; CABANE, Jean ; LEBBE, Céleste ; COPPO, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-3c0f03bf6cd7da49ae1204358396cce92846a21911cb7f87f059d8da841d3ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIDS-Related Opportunistic Infections - mortality</topic><topic>AIDS-Related Opportunistic Infections - virology</topic><topic>AIDS/HIV</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Aspartate aminotransferase</topic><topic>Biological and medical sciences</topic><topic>CD4 antigen</topic><topic>CD4 Lymphocyte Count</topic><topic>CD8 antigen</topic><topic>Cell number</topic><topic>Cytomegalovirus</topic><topic>Data processing</topic><topic>Demography</topic><topic>Female</topic><topic>France</topic><topic>Hematologic and hematopoietic diseases</topic><topic>highly active antiretroviral therapy</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - mortality</topic><topic>HIV-1 - immunology</topic><topic>Hodgkin's disease</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Kaplan-Meier Estimate</topic><topic>L-Lactate dehydrogenase</topic><topic>Lymphohistiocytosis, Hemophagocytic - complications</topic><topic>Lymphohistiocytosis, Hemophagocytic - mortality</topic><topic>Lymphohistiocytosis, Hemophagocytic - virology</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium</topic><topic>Other diseases. Hematologic involvement in other diseases</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>RNA</topic><topic>Splenomegaly</topic><topic>Survival</topic><topic>Tuberculosis</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FARDET, Laurence</creatorcontrib><creatorcontrib>LAMBOTTE, Olivier</creatorcontrib><creatorcontrib>MOLINA, Jean-Michel</creatorcontrib><creatorcontrib>MARTINEZ, Valérie</creatorcontrib><creatorcontrib>MEYNARD, Jean-Luc</creatorcontrib><creatorcontrib>KAMOUH, Wassim</creatorcontrib><creatorcontrib>GALICIER, Lionel</creatorcontrib><creatorcontrib>MARZAC, Christophe</creatorcontrib><creatorcontrib>DE LABARTHE, Adrienne</creatorcontrib><creatorcontrib>CABANE, Jean</creatorcontrib><creatorcontrib>LEBBE, Céleste</creatorcontrib><creatorcontrib>COPPO, Paul</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FARDET, Laurence</au><au>LAMBOTTE, Olivier</au><au>MOLINA, Jean-Michel</au><au>MARTINEZ, Valérie</au><au>MEYNARD, Jean-Luc</au><au>KAMOUH, Wassim</au><au>GALICIER, Lionel</au><au>MARZAC, Christophe</au><au>DE LABARTHE, Adrienne</au><au>CABANE, Jean</au><au>LEBBE, Céleste</au><au>COPPO, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>24</volume><issue>9</issue><spage>1299</spage><epage>1306</epage><pages>1299-1306</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>To describe features of reactive haemophagocytic syndrome (RHS) in HIV-1-infected adult patients. To compare characteristics of patients with malignancy-associated RHS and infection-associated RHS.
Retrospective study in three departments of Infectious Diseases/Internal Medicine at three French tertiary centres.
Medical charts of HIV-1-infected adult patients and RHS seen between January 2006 and December 2007 were reviewed. Demographic, clinical and laboratory data obtained at the time of RHS episode were compared between patients with malignancy-associated RHS and infection-associated RHS using non-parametric tests. The overall survival was assessed using the Kaplan-Meier method.
Fifty-eight HIV-1-infected patients were diagnosed with RHS [certain RHS n = 43, possible RHS n = 15, median (range) age 42 (23-85) years, men 76%]. At time of RHS, the median duration of HIV infection was 4 (0-22) years and 57% received HAART. The median CD4 lymphocyte count was 91 (2-387)/microl and 35% of patients had a plasma HIV-1 RNA less than 50 copies/ml. Underlying haemopathy/malignancy (Hodgkin lymphoma n = 10) or infection (tuberculosis n = 9, cytomegalovirus infection n = 5) were evidenced for 31 and 23 patients, respectively. Patients with haemopathy/malignancy-associated RHS presented more frequently with splenomegaly (97 vs. 70%, P < 0.01), lower aspartate aminotransferase (36 vs. 84 UI/l, P < 0.01) and lactate dehydrogenase (530 vs. 911 UI/l, P < 0.01) levels and CD8 cell count (234 vs. 588/microl, P < 0.01). Eighteen (31%) patients died. The overall survival was not statistically different between the two groups (P = 0.68).
In the HAART era, RHS is frequently associated with underlying haemopathy/malignancy, especially Hodgkin lymphoma. The prognosis remains poor but seems, however, better than in the pre-HAART era.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20559036</pmid><doi>10.1097/qad.0b013e328339e55b</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0269-9370 |
ispartof | AIDS (London), 2010-06, Vol.24 (9), p.1299-1306 |
issn | 0269-9370 1473-5571 |
language | eng |
recordid | cdi_proquest_miscellaneous_746010363 |
source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
subjects | Adult Age Aged Aged, 80 and over AIDS-Related Opportunistic Infections - mortality AIDS-Related Opportunistic Infections - virology AIDS/HIV Antiretroviral Therapy, Highly Active Aspartate aminotransferase Biological and medical sciences CD4 antigen CD4 Lymphocyte Count CD8 antigen Cell number Cytomegalovirus Data processing Demography Female France Hematologic and hematopoietic diseases highly active antiretroviral therapy HIV Infections - complications HIV Infections - drug therapy HIV Infections - mortality HIV-1 - immunology Hodgkin's disease Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infection Infectious diseases Kaplan-Meier Estimate L-Lactate dehydrogenase Lymphohistiocytosis, Hemophagocytic - complications Lymphohistiocytosis, Hemophagocytic - mortality Lymphohistiocytosis, Hemophagocytic - virology Male Malignancy Medical sciences Middle Aged Mycobacterium Other diseases. Hematologic involvement in other diseases Prognosis Retrospective Studies RNA Splenomegaly Survival Tuberculosis Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
title | Reactive haemophagocytic syndrome in 58 HIV-1-infected patients: clinical features, underlying diseases and prognosis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T05%3A40%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reactive%20haemophagocytic%20syndrome%20in%2058%20HIV-1-infected%20patients:%20clinical%20features,%20underlying%20diseases%20and%20prognosis&rft.jtitle=AIDS%20(London)&rft.au=FARDET,%20Laurence&rft.date=2010-06-01&rft.volume=24&rft.issue=9&rft.spage=1299&rft.epage=1306&rft.pages=1299-1306&rft.issn=0269-9370&rft.eissn=1473-5571&rft_id=info:doi/10.1097/qad.0b013e328339e55b&rft_dat=%3Cproquest_cross%3E733302497%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733302497&rft_id=info:pmid/20559036&rfr_iscdi=true |