RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line

Protein kinase C (PKC) is a multigene family of serine/threonine protein kinases involved in cell signaling pathways of proliferation and motility. PKC interacts with Rho GTPases in the regulation of the actin cytoskeleton. The PKC-alpha isozyme binds the Rho GTPase cdc42, and both are coordinated w...

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Veröffentlicht in:	Melanoma research 2010-06, Vol.20 (3), p.171-178
Hauptverfasser:	Byers, Hugh Randolph, Boissel, Sandrine J S, Tu, Chi, Park, Hee-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carbazoles - pharmacology cdc42 GTP-Binding Protein - metabolism Cell Line, Tumor Cell Movement Extracellular Matrix - metabolism Gene Expression Regulation, Neoplastic Humans Melanoma - metabolism Melanoma - pathology Naphthalenes - pharmacology Neoplasm Metastasis Protein Isoforms Protein Kinase C-alpha - genetics Protein Kinase C-alpha - physiology RNA Interference Time Factors
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