Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance
Local drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin and [Gd(HPDO3A)(H 2O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under mag...
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| Veröffentlicht in: | Journal of controlled release 2010-04, Vol.143 (1), p.120-127 |
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| creator | de Smet, Mariska Langereis, Sander den Bosch, Sandra van Grüll, Holger |
| description | Local drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin and [Gd(HPDO3A)(H
2O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under magnetic resonance image guidance. In particular, two temperature-sensitive systems composed of DPPC:MPPC:DPPE-PEG2000 (low temperature-sensitive liposomes, LTSL) and DPPC:HSPC:cholesterol:DPPE-PEG2000 (traditional temperature-sensitive liposomes, TTSL) were investigated. The co-encapsulation of [Gd(HPDO3A)(H
2O)], a clinically approved MRI contrast agent, did not influence the encapsulation and release of doxorubicin. The LTSL system showed a higher leakage of doxorubicin at 37
°C, but a faster release of doxorubicin at 42
°C compared to the TTSL system. Furthermore, the rapid release of both doxorubicin and the MRI contrast agent from the liposomes occurred near the melting phase transition temperature, making it possible to image the release of doxorubicin using MRI.
[Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2009.12.002 |
| format | Article |
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2O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under magnetic resonance image guidance. In particular, two temperature-sensitive systems composed of DPPC:MPPC:DPPE-PEG2000 (low temperature-sensitive liposomes, LTSL) and DPPC:HSPC:cholesterol:DPPE-PEG2000 (traditional temperature-sensitive liposomes, TTSL) were investigated. The co-encapsulation of [Gd(HPDO3A)(H
2O)], a clinically approved MRI contrast agent, did not influence the encapsulation and release of doxorubicin. The LTSL system showed a higher leakage of doxorubicin at 37
°C, but a faster release of doxorubicin at 42
°C compared to the TTSL system. Furthermore, the rapid release of both doxorubicin and the MRI contrast agent from the liposomes occurred near the melting phase transition temperature, making it possible to image the release of doxorubicin using MRI.
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2O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under magnetic resonance image guidance. In particular, two temperature-sensitive systems composed of DPPC:MPPC:DPPE-PEG2000 (low temperature-sensitive liposomes, LTSL) and DPPC:HSPC:cholesterol:DPPE-PEG2000 (traditional temperature-sensitive liposomes, TTSL) were investigated. The co-encapsulation of [Gd(HPDO3A)(H
2O)], a clinically approved MRI contrast agent, did not influence the encapsulation and release of doxorubicin. The LTSL system showed a higher leakage of doxorubicin at 37
°C, but a faster release of doxorubicin at 42
°C compared to the TTSL system. Furthermore, the rapid release of both doxorubicin and the MRI contrast agent from the liposomes occurred near the melting phase transition temperature, making it possible to image the release of doxorubicin using MRI.
[Display omitted]</description><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chemotherapy</subject><subject>Contrast Media - administration & dosage</subject><subject>Contrast Media - chemistry</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - chemistry</subject><subject>Drug Compounding</subject><subject>Drug delivery</subject><subject>Focused ultrasound</subject><subject>Gadolinium</subject><subject>General pharmacology</subject><subject>Heterocyclic Compounds - administration & dosage</subject><subject>Heterocyclic Compounds - chemistry</subject><subject>Humans</subject><subject>Hyperthermia</subject><subject>Image guidance</subject><subject>Kinetics</subject><subject>Lipids - chemistry</subject><subject>Liposome</subject><subject>Liposomes</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Organometallic Compounds - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Solubility</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Transition Temperature</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Mtq3DAUgGFRWppJ0kdo8aZkZVd3WasQQm40IRAmayFLZ4oG25pKdui8fTSMaZddafOdI-lH6CvBDcFE_tg2WxfHBH1DMdYNoQ3G9ANakVaxmmstPqJVcW3NpNAn6DTnLcZYMK4-oxOitdSYiRX6uYZhB8lOc4I6w5jDFN6g6sMu5jhArjYxVT7-iWnuggtj5aEvIO2refSQqqeXh-rXHLwdHZyjTxvbZ_iynGfo9fZmfX1fPz7fPVxfPdaOUznV3IMgoITqrKCcaaGkV7i1TDGJMQFJOUghWkI7K51rtcOq81gB4Q64UuwMXRz37lL8PUOezBCyg763I8Q5G8XLHinYQYqjdCnmnGBjdikMNu0NweaQ0WzNktEcMhpCTclY5r4tN8zdAP7f1NKtgO8LsNnZfpPK_0P-6ygVLSVaFnd5dFB6vAVIJrsApZUPCdxkfAz_eco769mTHA</recordid><startdate>20100402</startdate><enddate>20100402</enddate><creator>de Smet, Mariska</creator><creator>Langereis, Sander</creator><creator>den Bosch, Sandra van</creator><creator>Grüll, Holger</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20100402</creationdate><title>Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance</title><author>de Smet, Mariska ; Langereis, Sander ; den Bosch, Sandra van ; Grüll, Holger</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-4de51e757ba52439576d708a3736001e624e655812ba6cc89c07bd07e14ce4773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chemotherapy</topic><topic>Contrast Media - administration & dosage</topic><topic>Contrast Media - chemistry</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - chemistry</topic><topic>Drug Compounding</topic><topic>Drug delivery</topic><topic>Focused ultrasound</topic><topic>Gadolinium</topic><topic>General pharmacology</topic><topic>Heterocyclic Compounds - administration & dosage</topic><topic>Heterocyclic Compounds - chemistry</topic><topic>Humans</topic><topic>Hyperthermia</topic><topic>Image guidance</topic><topic>Kinetics</topic><topic>Lipids - chemistry</topic><topic>Liposome</topic><topic>Liposomes</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Organometallic Compounds - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Solubility</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Transition Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Smet, Mariska</creatorcontrib><creatorcontrib>Langereis, Sander</creatorcontrib><creatorcontrib>den Bosch, Sandra van</creatorcontrib><creatorcontrib>Grüll, Holger</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Smet, Mariska</au><au>Langereis, Sander</au><au>den Bosch, Sandra van</au><au>Grüll, Holger</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2010-04-02</date><risdate>2010</risdate><volume>143</volume><issue>1</issue><spage>120</spage><epage>127</epage><pages>120-127</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><coden>JCREEC</coden><abstract>Local drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin and [Gd(HPDO3A)(H
2O)] from different temperature-sensitive liposomes for applications in temperature-induced drug delivery under magnetic resonance image guidance. In particular, two temperature-sensitive systems composed of DPPC:MPPC:DPPE-PEG2000 (low temperature-sensitive liposomes, LTSL) and DPPC:HSPC:cholesterol:DPPE-PEG2000 (traditional temperature-sensitive liposomes, TTSL) were investigated. The co-encapsulation of [Gd(HPDO3A)(H
2O)], a clinically approved MRI contrast agent, did not influence the encapsulation and release of doxorubicin. The LTSL system showed a higher leakage of doxorubicin at 37
°C, but a faster release of doxorubicin at 42
°C compared to the TTSL system. Furthermore, the rapid release of both doxorubicin and the MRI contrast agent from the liposomes occurred near the melting phase transition temperature, making it possible to image the release of doxorubicin using MRI.
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| subjects | Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cell Survival - drug effects Chemistry, Pharmaceutical Chemotherapy Contrast Media - administration & dosage Contrast Media - chemistry Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Compounding Drug delivery Focused ultrasound Gadolinium General pharmacology Heterocyclic Compounds - administration & dosage Heterocyclic Compounds - chemistry Humans Hyperthermia Image guidance Kinetics Lipids - chemistry Liposome Liposomes Magnetic Resonance Imaging Medical sciences Organometallic Compounds - administration & dosage Organometallic Compounds - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemistry Solubility Technology, Pharmaceutical - methods Transition Temperature |
| title | Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance |
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