Hybrid hyaluronan hydrogel encapsulating nanogel as a protein nanocarrier: New system for sustained delivery of protein with a chaperone-like function

Novel hybrid hyaluronan (HA) hydrogel encapsulating nanogels was designed for sustained delivery of protein. HA modified with 2-aminoethyl methacrylate was cross-linked via Michael addition in the presence of cholesteryl group-bearing pullulan (CHP) nanogels. The nanogels were physically entrapped a...

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Veröffentlicht in:	Journal of controlled release 2010-03, Vol.142 (3), p.483-489
Hauptverfasser:	Hirakura, Tai, Yasugi, Kenji, Nemoto, Takayuki, Sato, Mika, Shimoboji, Tsuyoshi, Aso, Yoshinori, Morimoto, Nobuyuki, Akiyoshi, Kazunari
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cross-Linking Reagents - chemistry Delayed-Action Preparations Drug Carriers - chemistry General pharmacology hyaluronan Hyaluronic Acid - chemistry hybrid hydrogel Hydrogels - chemistry Injections, Intravenous Male Medical sciences Microscopy, Electron, Transmission Molecular Chaperones - administration & dosage Molecular Chaperones - blood Molecular Chaperones - pharmacokinetics nanogel Nanostructures - chemistry Peptide Fragments - administration & dosage Peptide Fragments - blood Peptide Fragments - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments protein delivery Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - blood Recombinant Proteins - pharmacokinetics Solubility Surface Properties sustained release
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