Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev

Based on the design from the MO calculation, 5,6-dihydrovaltrate ( 2) was synthesized and revealed to be the bioisostere of valtrate ( 1) showing anti-HIV activity by inhibition for nuclear export of Rev. Rational design by the MO calculation disclosed 5,6-dihydrovaltrate ( 2) as the bioisostere of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-04, Vol.20 (7), p.2159-2162
Hauptverfasser:	Tamura, Satoru, Shimizu, Nobuhiro, Fujiwara, Katsuaki, Kaneko, Masafumi, Kimura, Tominori, Murakami, Nobutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Anti-HIV Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Bioisostere Biological and medical sciences Gene Products, rev - metabolism HeLa Cells HIV Infections - drug therapy Human immunodeficiency virus Humans Iridoid Iridoids - chemistry Iridoids - pharmacology Medical sciences Molecular Conformation Pharmacology. Drug treatments Rev-export inhibitor Valtrate
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