FOXE1 is a target for aberrant methylation in cutaneous squamous cell carcinoma

Summary Background Several cancer‐related genes are silenced by promoter hypermethylation in skin cancers. However, to date the somatic epigenetic events that occur in cutaneous squamous cell carcinoma (SCC) tumorigenesis have not been well defined. Objectives To examine epigenetic abnormalities o...

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Veröffentlicht in:	British journal of dermatology (1951) 2010-05, Vol.162 (5), p.1093-1097
Hauptverfasser:	Venza, I., Visalli, M., Tripodo, B., De Grazia, G., Loddo, S., Teti, D., Venza, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antimetabolites, Antineoplastic - therapeutic use Azacitidine - analogs & derivatives Azacitidine - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism cutaneous squamous cell carcinoma Dermatology DNA Methylation DNA, Neoplasm - genetics Female Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - genetics FOXE1 gene gene expression Genetic Predisposition to Disease Humans Male Medical sciences Middle Aged Neoplasm Proteins - biosynthesis promoter hypermethylation Promoter Regions, Genetic - genetics RNA, Messenger - genetics RNA, Neoplasm - genetics Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Tumors of the skin and soft tissue. Premalignant lesions
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