Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs

Epileptic seizure activity is associated with an imbalance between excitatory and inhibitory synaptic activities. The latter is mediated by GABA, and several currently used antiepileptic drugs target entities of the GABAergic synapse such as the receptors or the inactivation mechanism consisting of...

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Veröffentlicht in:	Pharmacology & therapeutics (Oxford) 2010-03, Vol.125 (3), p.394-401
Hauptverfasser:	Madsen, Karsten K, White, H Steve, Schousboe, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Astrocytes - drug effects Astrocytes - metabolism Brain - drug effects Brain - metabolism Drug Delivery Systems - methods Epilepsy - drug therapy GABA Plasma Membrane Transport Proteins - genetics GABA Plasma Membrane Transport Proteins - metabolism GABA Uptake Inhibitors gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - physiology Humans Models, Neurological Molecular Structure Neurons - drug effects Neurons - metabolism Neurons - physiology Neurotransmitter Uptake Inhibitors - chemistry Neurotransmitter Uptake Inhibitors - pharmacology Neurotransmitter Uptake Inhibitors - therapeutic use
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