Amine Exchange and Unexpected Ring-Opening Reactions of Pyranone Derivatives: Synthesis of 3-Amino-Substituted Oxonaphthopyran-carbaldehydes and Tetrahydropyrimidinethanones as New Potential Oligonucleotide Stabilization Agents

3‐[(3‐Aminopropyl)amino]‐1‐oxo‐1H‐naphtho[2,1‐b]pyran‐2‐carbaldehyde (10) was synthesized by nucleophilic substitution reaction of 2‐(3‐dimethylamino)‐1‐oxo‐1H‐naphtho[2,1‐b]pyran‐2‐carbaldehyde (9) and the monoprotected propane‐1,3‐diamine. The reaction with the unprotected reagent led to the unexp...

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Veröffentlicht in:	Helvetica chimica acta 2002-06, Vol.85 (6), p.1698-1705
Hauptverfasser:	Sottofattori, Enzo, Anzaldi, Maria, Balbi, Alessandro, Artali, Roberto, Bombieri, Gabriella
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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