Single nucleotide polymorphism‐arrays provide new insights in the pathogenesis of post‐transplant diffuse large B‐cell lymphoma
Summary Post‐transplant lymphoproliferative disorders (PTLD) are complications of solid organ transplantation associated with severe morbidity and mortality. Diffuse large B‐cell lymphoma (DLBCL) represents the most common form of monomorphic PTLD. We studied 44 cases of post‐transplant DLBCL (PT‐DL...
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| Veröffentlicht in: | British journal of haematology 2010-05, Vol.149 (4), p.569-577 |
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| creator | Rinaldi, Andrea Capello, Daniela Scandurra, Marta Greiner, Timothy C. Chan, Wing C. Bhagat, Govind Rossi, Davide Morra, Enrica Paulli, Marco Rambaldi, Alessandro Rancoita, Paola M. V. Inghirami, Giorgio Ponzoni, Maurilio Moreno, Santiago M. Piris, Miguel A. Mian, Michael Chigrinova, Ekaterina Zucca, Emanuele Favera, Riccardo D. Gaidano, Gianluca Kwee, Ivo Bertoni, Francesco |
| description | Summary
Post‐transplant lymphoproliferative disorders (PTLD) are complications of solid organ transplantation associated with severe morbidity and mortality. Diffuse large B‐cell lymphoma (DLBCL) represents the most common form of monomorphic PTLD. We studied 44 cases of post‐transplant DLBCL (PT‐DLBCL) with high‐density genome wide single nucleotide polymorphism‐based arrays, and compared them with 105 cases of immunocompetent DLBCL (IC‐DLBCL) and 28 cases of Human Immunodeficiency Virus‐associated DLBCL (HIV‐DLBCL). PT‐DLBCL showed a genomic profile with specific features, although their genomic complexity was overall similar to that observed in IC‐ and HIV‐DLBCL. Among the loci more frequently deleted in PT‐DLBCL there were small interstitial deletions targeting known fragile sites, such as FRA1B, FRA2E and FRA3B. Deletions at 2p16.1 (FRA2E) were the most common lesions in PT‐DLBCL, occurring at a frequency that was significantly higher than in IC‐DLBCL. Genetic lesions that characterized post‐germinal center IC‐DLBCL were under‐represented in our series of PT‐DLBCL. Two other differences between IC‐DLBCL and PT‐DLBCL were the lack of del(13q14.3) (MIR15/MIR16) and of copy neutral LOH affecting 6p [major histocompatibility complex (MHC) locus] in the latter group. In conclusion, PT‐DLBCL presented unique features when compared with IC‐DLBCL. Changes in PT‐DLBCL were partially different to those in HIV‐DLBCL, suggesting different pathogenetic mechanisms in the two conditions linked to immunodeficiency. |
| doi_str_mv | 10.1111/j.1365-2141.2010.08125.x |
| format | Article |
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Post‐transplant lymphoproliferative disorders (PTLD) are complications of solid organ transplantation associated with severe morbidity and mortality. Diffuse large B‐cell lymphoma (DLBCL) represents the most common form of monomorphic PTLD. We studied 44 cases of post‐transplant DLBCL (PT‐DLBCL) with high‐density genome wide single nucleotide polymorphism‐based arrays, and compared them with 105 cases of immunocompetent DLBCL (IC‐DLBCL) and 28 cases of Human Immunodeficiency Virus‐associated DLBCL (HIV‐DLBCL). PT‐DLBCL showed a genomic profile with specific features, although their genomic complexity was overall similar to that observed in IC‐ and HIV‐DLBCL. Among the loci more frequently deleted in PT‐DLBCL there were small interstitial deletions targeting known fragile sites, such as FRA1B, FRA2E and FRA3B. Deletions at 2p16.1 (FRA2E) were the most common lesions in PT‐DLBCL, occurring at a frequency that was significantly higher than in IC‐DLBCL. Genetic lesions that characterized post‐germinal center IC‐DLBCL were under‐represented in our series of PT‐DLBCL. Two other differences between IC‐DLBCL and PT‐DLBCL were the lack of del(13q14.3) (MIR15/MIR16) and of copy neutral LOH affecting 6p [major histocompatibility complex (MHC) locus] in the latter group. In conclusion, PT‐DLBCL presented unique features when compared with IC‐DLBCL. Changes in PT‐DLBCL were partially different to those in HIV‐DLBCL, suggesting different pathogenetic mechanisms in the two conditions linked to immunodeficiency.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2010.08125.x</identifier><identifier>PMID: 20230398</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Affymetrix ; Biological and medical sciences ; Comparative Genomic Hybridization ; diffuse large B‐cell lymphoma ; DNA, Neoplasm - genetics ; Gene Expression Profiling - methods ; Genetic Predisposition to Disease ; Hematologic and hematopoietic diseases ; Human immunodeficiency virus ; Humans ; Immunocompromised Host ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; immunodeficiency ; Immunopathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Loss of Heterozygosity ; Lymphoma, AIDS-Related - genetics ; Lymphoma, AIDS-Related - immunology ; Lymphoma, Large B-Cell, Diffuse - etiology ; Lymphoma, Large B-Cell, Diffuse - genetics ; Lymphoma, Large B-Cell, Diffuse - immunology ; Medical sciences ; Organ Transplantation - adverse effects ; Polymorphism, Single Nucleotide ; Recurrence ; solid organ transplant</subject><ispartof>British journal of haematology, 2010-05, Vol.149 (4), p.569-577</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5465-a12608bce7e1cbada9a289a2d8179136389fa66eced45ae4cac60fec32fca50f3</citedby><cites>FETCH-LOGICAL-c5465-a12608bce7e1cbada9a289a2d8179136389fa66eced45ae4cac60fec32fca50f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2010.08125.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2010.08125.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22759819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20230398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rinaldi, Andrea</creatorcontrib><creatorcontrib>Capello, Daniela</creatorcontrib><creatorcontrib>Scandurra, Marta</creatorcontrib><creatorcontrib>Greiner, Timothy C.</creatorcontrib><creatorcontrib>Chan, Wing C.</creatorcontrib><creatorcontrib>Bhagat, Govind</creatorcontrib><creatorcontrib>Rossi, Davide</creatorcontrib><creatorcontrib>Morra, Enrica</creatorcontrib><creatorcontrib>Paulli, Marco</creatorcontrib><creatorcontrib>Rambaldi, Alessandro</creatorcontrib><creatorcontrib>Rancoita, Paola M. V.</creatorcontrib><creatorcontrib>Inghirami, Giorgio</creatorcontrib><creatorcontrib>Ponzoni, Maurilio</creatorcontrib><creatorcontrib>Moreno, Santiago M.</creatorcontrib><creatorcontrib>Piris, Miguel A.</creatorcontrib><creatorcontrib>Mian, Michael</creatorcontrib><creatorcontrib>Chigrinova, Ekaterina</creatorcontrib><creatorcontrib>Zucca, Emanuele</creatorcontrib><creatorcontrib>Favera, Riccardo D.</creatorcontrib><creatorcontrib>Gaidano, Gianluca</creatorcontrib><creatorcontrib>Kwee, Ivo</creatorcontrib><creatorcontrib>Bertoni, Francesco</creatorcontrib><title>Single nucleotide polymorphism‐arrays provide new insights in the pathogenesis of post‐transplant diffuse large B‐cell lymphoma</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Post‐transplant lymphoproliferative disorders (PTLD) are complications of solid organ transplantation associated with severe morbidity and mortality. Diffuse large B‐cell lymphoma (DLBCL) represents the most common form of monomorphic PTLD. We studied 44 cases of post‐transplant DLBCL (PT‐DLBCL) with high‐density genome wide single nucleotide polymorphism‐based arrays, and compared them with 105 cases of immunocompetent DLBCL (IC‐DLBCL) and 28 cases of Human Immunodeficiency Virus‐associated DLBCL (HIV‐DLBCL). PT‐DLBCL showed a genomic profile with specific features, although their genomic complexity was overall similar to that observed in IC‐ and HIV‐DLBCL. Among the loci more frequently deleted in PT‐DLBCL there were small interstitial deletions targeting known fragile sites, such as FRA1B, FRA2E and FRA3B. Deletions at 2p16.1 (FRA2E) were the most common lesions in PT‐DLBCL, occurring at a frequency that was significantly higher than in IC‐DLBCL. Genetic lesions that characterized post‐germinal center IC‐DLBCL were under‐represented in our series of PT‐DLBCL. Two other differences between IC‐DLBCL and PT‐DLBCL were the lack of del(13q14.3) (MIR15/MIR16) and of copy neutral LOH affecting 6p [major histocompatibility complex (MHC) locus] in the latter group. In conclusion, PT‐DLBCL presented unique features when compared with IC‐DLBCL. Changes in PT‐DLBCL were partially different to those in HIV‐DLBCL, suggesting different pathogenetic mechanisms in the two conditions linked to immunodeficiency.</description><subject>Affymetrix</subject><subject>Biological and medical sciences</subject><subject>Comparative Genomic Hybridization</subject><subject>diffuse large B‐cell lymphoma</subject><subject>DNA, Neoplasm - genetics</subject><subject>Gene Expression Profiling - methods</subject><subject>Genetic Predisposition to Disease</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>immunodeficiency</subject><subject>Immunopathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Loss of Heterozygosity</subject><subject>Lymphoma, AIDS-Related - genetics</subject><subject>Lymphoma, AIDS-Related - immunology</subject><subject>Lymphoma, Large B-Cell, Diffuse - etiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Lymphoma, Large B-Cell, Diffuse - immunology</subject><subject>Medical sciences</subject><subject>Organ Transplantation - adverse effects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Recurrence</subject><subject>solid organ transplant</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkTtvFDEQxy0EIkfgKyA3iOoOe70Pb0FBIiCgSBRAbc15x7c-eR94dkmuo6HnM_JJ8HJHKMGS5ZHnN88_Y1yKjUznxX4jVVmsM5nLTSbSr9AyKza399jqznGfrYQQ1VqKXJ-xR0R7IaQShXzIzjKRKaFqvWLfP_p-F5D3sw04TL5BPg7h0A1xbD11P7_9gBjhQHyMw9fF2-MN9z35XTtRMvjUpgiY2mGHPZInPriUgaYUOUXoaQzQT7zxzs2EPEDcIb9ITosh8FRobIcOHrMHDgLhk9N7zj6_ef3p8mp9_eHtu8tX12tb5GkskFkp9NZihdJuoYEaMp1uo2VVp8GVrh2UJVps8gIwt2BL4dCqzFkohFPn7Pkxb5rmy4w0mc7T0gn0OMxkqrwUIldS_5tUac-yLhZSH0kbB6KIzozRdxAPRgqzqGX2ZhHFLKKYRS3zWy1zm0KfnorM2w6bu8A_8iTg2QkAshBcWqj19JfLqqLWsk7cyyN34wMe_rsBc_H-arHULzAitq0</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Rinaldi, Andrea</creator><creator>Capello, Daniela</creator><creator>Scandurra, Marta</creator><creator>Greiner, Timothy C.</creator><creator>Chan, Wing C.</creator><creator>Bhagat, Govind</creator><creator>Rossi, Davide</creator><creator>Morra, Enrica</creator><creator>Paulli, Marco</creator><creator>Rambaldi, Alessandro</creator><creator>Rancoita, Paola M. V.</creator><creator>Inghirami, Giorgio</creator><creator>Ponzoni, Maurilio</creator><creator>Moreno, Santiago M.</creator><creator>Piris, Miguel A.</creator><creator>Mian, Michael</creator><creator>Chigrinova, Ekaterina</creator><creator>Zucca, Emanuele</creator><creator>Favera, Riccardo D.</creator><creator>Gaidano, Gianluca</creator><creator>Kwee, Ivo</creator><creator>Bertoni, Francesco</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201005</creationdate><title>Single nucleotide polymorphism‐arrays provide new insights in the pathogenesis of post‐transplant diffuse large B‐cell lymphoma</title><author>Rinaldi, Andrea ; Capello, Daniela ; Scandurra, Marta ; Greiner, Timothy C. ; Chan, Wing C. ; Bhagat, Govind ; Rossi, Davide ; Morra, Enrica ; Paulli, Marco ; Rambaldi, Alessandro ; Rancoita, Paola M. V. ; Inghirami, Giorgio ; Ponzoni, Maurilio ; Moreno, Santiago M. ; Piris, Miguel A. ; Mian, Michael ; Chigrinova, Ekaterina ; Zucca, Emanuele ; Favera, Riccardo D. ; Gaidano, Gianluca ; Kwee, Ivo ; Bertoni, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5465-a12608bce7e1cbada9a289a2d8179136389fa66eced45ae4cac60fec32fca50f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Affymetrix</topic><topic>Biological and medical sciences</topic><topic>Comparative Genomic Hybridization</topic><topic>diffuse large B‐cell lymphoma</topic><topic>DNA, Neoplasm - genetics</topic><topic>Gene Expression Profiling - methods</topic><topic>Genetic Predisposition to Disease</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>immunodeficiency</topic><topic>Immunopathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Loss of Heterozygosity</topic><topic>Lymphoma, AIDS-Related - genetics</topic><topic>Lymphoma, AIDS-Related - immunology</topic><topic>Lymphoma, Large B-Cell, Diffuse - etiology</topic><topic>Lymphoma, Large B-Cell, Diffuse - genetics</topic><topic>Lymphoma, Large B-Cell, Diffuse - immunology</topic><topic>Medical sciences</topic><topic>Organ Transplantation - adverse effects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Recurrence</topic><topic>solid organ transplant</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rinaldi, Andrea</creatorcontrib><creatorcontrib>Capello, Daniela</creatorcontrib><creatorcontrib>Scandurra, Marta</creatorcontrib><creatorcontrib>Greiner, Timothy C.</creatorcontrib><creatorcontrib>Chan, Wing C.</creatorcontrib><creatorcontrib>Bhagat, Govind</creatorcontrib><creatorcontrib>Rossi, Davide</creatorcontrib><creatorcontrib>Morra, Enrica</creatorcontrib><creatorcontrib>Paulli, Marco</creatorcontrib><creatorcontrib>Rambaldi, Alessandro</creatorcontrib><creatorcontrib>Rancoita, Paola M. V.</creatorcontrib><creatorcontrib>Inghirami, Giorgio</creatorcontrib><creatorcontrib>Ponzoni, Maurilio</creatorcontrib><creatorcontrib>Moreno, Santiago M.</creatorcontrib><creatorcontrib>Piris, Miguel A.</creatorcontrib><creatorcontrib>Mian, Michael</creatorcontrib><creatorcontrib>Chigrinova, Ekaterina</creatorcontrib><creatorcontrib>Zucca, Emanuele</creatorcontrib><creatorcontrib>Favera, Riccardo D.</creatorcontrib><creatorcontrib>Gaidano, Gianluca</creatorcontrib><creatorcontrib>Kwee, Ivo</creatorcontrib><creatorcontrib>Bertoni, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rinaldi, Andrea</au><au>Capello, Daniela</au><au>Scandurra, Marta</au><au>Greiner, Timothy C.</au><au>Chan, Wing C.</au><au>Bhagat, Govind</au><au>Rossi, Davide</au><au>Morra, Enrica</au><au>Paulli, Marco</au><au>Rambaldi, Alessandro</au><au>Rancoita, Paola M. V.</au><au>Inghirami, Giorgio</au><au>Ponzoni, Maurilio</au><au>Moreno, Santiago M.</au><au>Piris, Miguel A.</au><au>Mian, Michael</au><au>Chigrinova, Ekaterina</au><au>Zucca, Emanuele</au><au>Favera, Riccardo D.</au><au>Gaidano, Gianluca</au><au>Kwee, Ivo</au><au>Bertoni, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single nucleotide polymorphism‐arrays provide new insights in the pathogenesis of post‐transplant diffuse large B‐cell lymphoma</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2010-05</date><risdate>2010</risdate><volume>149</volume><issue>4</issue><spage>569</spage><epage>577</epage><pages>569-577</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Post‐transplant lymphoproliferative disorders (PTLD) are complications of solid organ transplantation associated with severe morbidity and mortality. Diffuse large B‐cell lymphoma (DLBCL) represents the most common form of monomorphic PTLD. We studied 44 cases of post‐transplant DLBCL (PT‐DLBCL) with high‐density genome wide single nucleotide polymorphism‐based arrays, and compared them with 105 cases of immunocompetent DLBCL (IC‐DLBCL) and 28 cases of Human Immunodeficiency Virus‐associated DLBCL (HIV‐DLBCL). PT‐DLBCL showed a genomic profile with specific features, although their genomic complexity was overall similar to that observed in IC‐ and HIV‐DLBCL. Among the loci more frequently deleted in PT‐DLBCL there were small interstitial deletions targeting known fragile sites, such as FRA1B, FRA2E and FRA3B. Deletions at 2p16.1 (FRA2E) were the most common lesions in PT‐DLBCL, occurring at a frequency that was significantly higher than in IC‐DLBCL. Genetic lesions that characterized post‐germinal center IC‐DLBCL were under‐represented in our series of PT‐DLBCL. Two other differences between IC‐DLBCL and PT‐DLBCL were the lack of del(13q14.3) (MIR15/MIR16) and of copy neutral LOH affecting 6p [major histocompatibility complex (MHC) locus] in the latter group. In conclusion, PT‐DLBCL presented unique features when compared with IC‐DLBCL. Changes in PT‐DLBCL were partially different to those in HIV‐DLBCL, suggesting different pathogenetic mechanisms in the two conditions linked to immunodeficiency.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20230398</pmid><doi>10.1111/j.1365-2141.2010.08125.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of haematology, 2010-05, Vol.149 (4), p.569-577 |
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| subjects | Affymetrix Biological and medical sciences Comparative Genomic Hybridization diffuse large B‐cell lymphoma DNA, Neoplasm - genetics Gene Expression Profiling - methods Genetic Predisposition to Disease Hematologic and hematopoietic diseases Human immunodeficiency virus Humans Immunocompromised Host Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies immunodeficiency Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Loss of Heterozygosity Lymphoma, AIDS-Related - genetics Lymphoma, AIDS-Related - immunology Lymphoma, Large B-Cell, Diffuse - etiology Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - immunology Medical sciences Organ Transplantation - adverse effects Polymorphism, Single Nucleotide Recurrence solid organ transplant |
| title | Single nucleotide polymorphism‐arrays provide new insights in the pathogenesis of post‐transplant diffuse large B‐cell lymphoma |
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