Fatal exacerbation of type B chronic hepatitis triggered by changes in relaxed circular viral DNA synthesis and virion secretion

Virological features of fulminant liver disease-causing hepatitis B virus (HBV) have not been fully elucidated. We studied longitudinally the viruses obtained before and after fulminant liver disease in a patient with chronic HBV infection showing fatal exacerbation. HBV strains were obtained before...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-03, Vol.394 (1), p.87-93
Hauptverfasser:	Ohkawa, Kazuyoshi, Takehara, Tetsuo, Ishida, Hisashi, Kodama, Takahiro, Shimizu, Satoshi, Hikita, Hayato, Yamamoto, Masashi, Kohga, Keisuke, Sasakawa, Akira, Uemura, Akio, Sakamori, Ryotaro, Yamaguchi, Shinjiro, Li, Wei, Hosui, Atsushi, Miyagi, Takuya, Tatsumi, Tomohide, Katayama, Kazuhiro, Hayashi, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over DNA Replication DNA, Circular - genetics DNA, Viral - genetics Fatal exacerbation of type B chronic hepatitis Genetic Variation Hepatitis B Surface Antigens - genetics Hepatitis B Virus Hepatitis B virus - genetics Hepatitis B virus - physiology Hepatitis B, Chronic - complications Hepatitis B, Chronic - virology Humans Liver Failure, Acute - virology Male Protein Precursors - genetics Relaxed circular hepatitis B virus DNA synthesis Virion - genetics Virion - physiology Virion secretion Virus Release - genetics Virus Release - physiology
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