Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons

Abstract Elevated temperature and decreased extracellular pH are hallmarks of inflammatory pain states. Dorsal root ganglia (DRG) neurons are integral in transferring painful stimuli from the periphery to central sites. This study investigated the effect of elevated temperatures on the response of D...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2010-05, Vol.1329, p.55-66
Hauptverfasser:	Neelands, Torben R, Zhang, Xu-Feng, McDonald, Heath, Puttfarcken, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels Acidic pH Age Factors Animals Animals, Newborn ASIC Biological and medical sciences Cells, Cultured Central nervous system DRG Electrophysiology Fundamental and applied biological sciences. Psychology Ganglia, Spinal - cytology Hydrogen-Ion Concentration Nerve Tissue Proteins - metabolism Neurology Neurons - metabolism Neurons - physiology Patch-Clamp Techniques Rats Rats, Sprague-Dawley Sodium Channels - metabolism Temperature TRPV Cation Channels - metabolism TRPV1 Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!