MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons

DNA methylation-dependent gene silencing is initiated by DNA methyltransferases (DNMTs) and mediated by methyl-binding domain proteins (MBDs), which recruit histone deacetylases (HDACs) to silence DNA, a process that is essential for normal development. Here, we show that the MBD proteins MBD2 and M...

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Veröffentlicht in:	Molecular and cellular neuroscience 2010-05, Vol.44 (1), p.55-67
Hauptverfasser:	MacDonald, Jessica L., Verster, Adrian, Berndt, Anthony, Roskams, A. Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Proliferation DNA Methylation - physiology DNA-Binding Proteins - genetics Epigenesis, Genetic - genetics Epigenetics GAP-43 Protein - genetics GAP-43 Protein - metabolism Gene Expression Regulation, Developmental - genetics Gene Silencing - physiology Histone deacetylase Histone Deacetylases - genetics Histone Deacetylases - metabolism Male Methyl-CpG-Binding Protein 2 - genetics Mice Mice, Knockout Neural development Neurogenesis Neurogenesis - physiology Olfactory Mucosa - cytology Olfactory Mucosa - embryology Olfactory Mucosa - growth & development Olfactory Receptor Neurons - cytology Olfactory Receptor Neurons - metabolism Promoter Regions, Genetic - genetics
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