In vivo and in vitro characterization of CCK8 bearing a histidine-based chelator labeled with 99mTc-tricarbonyl

The development of receptor targeting radiolabeled ligands has gained much interest in recent years for diagnostic and therapeutic applications in nuclear medicine. Cholecystokinin (CCK) receptors have been shown to be overexpressed in a subset of neuroendocrine and other tumors. We are evaluating b...

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Veröffentlicht in:	Biopolymers 2008, Vol.90 (5), p.707-712
Hauptverfasser:	D'Andrea, Luca D., Testa, Irma, Panico, MariaRosaria, Di Stasi, Rossella, Caracò, Corradina, Tarallo, Laura, Arra, Claudio, Barbieri, Antonio, Romanelli, Alessandra, Aloj, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals carbonyl Cell Line, Tumor Chelating Agents - chemistry Cholecystokinin - chemical synthesis Cholecystokinin - metabolism cholecystokinin receptors Drug Design Histidine - analogs & derivatives Histidine - chemistry Histidine - metabolism Humans imaging Isotope Labeling Mice Mice, Nude Neoplasm Transplantation organometallic complexes Organotechnetium Compounds - metabolism Peptide Fragments - chemical synthesis Peptide Fragments - metabolism radiopeptide Radiopharmaceuticals Receptors, Cholecystokinin - metabolism technetium Transplantation, Heterologous
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