Therapeutic potential of the chemokine receptor CXCR4 antagonists as multifunctional agents

The chemokine receptor CXCR4 possesses multiple critical functions in normal and pathologic physiology. CXCR4 is a G‐protein‐coupled receptor that transduces signals of its endogenous ligand, the chemokine CXCL12 (stromal cell‐derived factor‐1, SDF‐1). The interaction between CXCL12 and CXCR4 plays...

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Veröffentlicht in:	Biopolymers 2007, Vol.88 (2), p.279-289
Hauptverfasser:	Tsutsumi, Hiroshi, Tanaka, Tomohiro, Ohashi, Nami, Masuno, Hiroyuki, Tamamura, Hirokazu, Hiramatsu, Kenichi, Araki, Takanobu, Ueda, Satoshi, Oishi, Shinya, Fujii, Nobutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antirheumatic Agents - chemistry Antirheumatic Agents - pharmacology cancer metastasis Cell Line, Tumor chemokine receptor HIV infection HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Humans In Vitro Techniques leukemia cell progression low-molecular weight CXCR4 antagonist Molecular Sequence Data Oligopeptides - chemistry Oligopeptides - pharmacology Peptides - chemistry Peptides - pharmacology Receptors, CXCR4 - antagonists & inhibitors rheumatoid arthritis Virus Internalization - drug effects
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