hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury

J. Neurochem. (2010) 113, 930-942. Granulocyte-colony stimulating factor (G-CSF) is a potent hematopoietic factor that drives differentiation of neutrophilic granulocytes. We have recently shown that G-CSF also acts as a neuronal growth factor, protects neurons in vitro and in vivo, and has regenera...

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Veröffentlicht in:	Journal of neurochemistry 2010-05, Vol.113 (4), p.930-942
Hauptverfasser:	Pitzer, Claudia, Klussmann, Stefan, Krüger, Carola, Letellier, Elisabeth, Plaas, Christian, Dittgen, Tanjew, Kirsch, Friederike, Stieltjes, Bram, Weber, Daniela, Laage, Rico, Martin-Villalba, Ana, Schneider, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects Apoptosis - physiology bcl-X Protein - drug effects bcl-X Protein - metabolism Biochemistry Biological and medical sciences Cell Differentiation - drug effects Cell Differentiation - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cerebrospinal fluid. Meninges. Spinal cord Disease Models, Animal drug drugs Female G-CSF Granulocyte Colony-Stimulating Factor - pharmacology Granulocyte Colony-Stimulating Factor - therapeutic use Growth Cones - drug effects Growth Cones - physiology Growth Cones - ultrastructure hematopoietic growth factor Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Mice Nerve Growth Factors - pharmacology Nerve Growth Factors - therapeutic use Nervous system (semeiology, syndromes) Neurites - drug effects Neurites - ultrastructure Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Pyramidal Tracts - drug effects Pyramidal Tracts - injuries Pyramidal Tracts - physiology Rats Rats, Wistar Receptors, Granulocyte Colony-Stimulating Factor - drug effects Receptors, Granulocyte Colony-Stimulating Factor - metabolism Recovery of Function - drug effects Recovery of Function - physiology regeneration Rodents Spinal cord injuries Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - physiopathology spinal cord injury therapeutics therapy Traumas. Diseases due to physical agents Treatment Outcome Up-Regulation - drug effects Up-Regulation - physiology
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