Human spleen tyrosine kinase (Syk) recombinant expression systems for high-throughput assays

Spleen tyrosine kinase (Syk) is an important non‐receptor tyrosine kinase and its aberrant regulation is associated with a variety of allergic disorders and autoimmune diseases. To identify small molecule inhibitors of Syk in high‐throughput assays, recombinant Syk protein is needed in bulk quantity...

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Veröffentlicht in:	Biotechnology journal 2010-02, Vol.5 (2), p.201-212
Hauptverfasser:	Singh, Deepika, Rani, Reema, Rajendran, Resmi, Kaur, Namrata Jit, Pandey, Abhinav, Chopra, Puneet, Jain, Tarun, Jain, Manish Kumar, Grover, Sonam, Arya, Ranjana, Saini, Kulvinder Singh
Format:	Artikel
Sprache:	eng
Schlagworte:	Baculoviridae - genetics Baculovirus Circular Dichroism Cloning, Molecular - methods Dictyostelium - enzymology Dictyostelium - genetics Dictyostelium - virology Dictyostelium discoideum Enzyme Stability Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - virology Expression High-Throughput Screening Assays - methods Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - genetics Microscopy, Fluorescence Models, Molecular Phosphorylation Protein Structure, Secondary Protein-Tyrosine Kinases - biosynthesis Protein-Tyrosine Kinases - chemistry Protein-Tyrosine Kinases - genetics Purification Recombinant Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics Syk Syk Kinase
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