Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications
Magnetic resonance spectroscopy (MRS) offers a unique, noninvasive approach to assess pediatric neurological abnormalities at microscopic levels by quantifying cellular metabolites. The most widely available MRS method, proton ( 1 H; hydrogen) spectroscopy, is FDA approved for general use and can be...
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| Veröffentlicht in: | Pediatric radiology 2010, Vol.40 (1), p.3-30, Article 3 |
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| creator | Panigrahy, Ashok Nelson, Marvin D. Blüml, Stefan |
| description | Magnetic resonance spectroscopy (MRS) offers a unique, noninvasive approach to assess pediatric neurological abnormalities at microscopic levels by quantifying cellular metabolites. The most widely available MRS method, proton (
1
H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered by clinicians for pediatric neuroimaging studies if indicated. There are a multitude of both acquisition and post-processing methods that can be used in the implementation of MR spectroscopy. MRS in pediatric neuroimaging is challenging to interpret because of dramatic normal developmental changes that occur in metabolites, particularly in the first year of life. Still, MRS has been proven to provide additional clinically relevant information for several pediatric neurological disease processes such as brain tumors, infectious processes, white matter disorders, and neonatal injury. MRS can also be used as a powerful quantitative research tool. In this article, specific research applications using MRS will be demonstrated in relation to neonatal brain injury and pediatric brain tumor imaging. |
| doi_str_mv | 10.1007/s00247-009-1450-z |
| format | Article |
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1
H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered by clinicians for pediatric neuroimaging studies if indicated. There are a multitude of both acquisition and post-processing methods that can be used in the implementation of MR spectroscopy. MRS in pediatric neuroimaging is challenging to interpret because of dramatic normal developmental changes that occur in metabolites, particularly in the first year of life. Still, MRS has been proven to provide additional clinically relevant information for several pediatric neurological disease processes such as brain tumors, infectious processes, white matter disorders, and neonatal injury. MRS can also be used as a powerful quantitative research tool. In this article, specific research applications using MRS will be demonstrated in relation to neonatal brain injury and pediatric brain tumor imaging.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-009-1450-z</identifier><identifier>PMID: 19937238</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Biomarkers - analysis ; Biomedical Research - trends ; Brain Injuries - diagnosis ; Brain Injuries - metabolism ; Brain Neoplasms - diagnosis ; Brain Neoplasms - metabolism ; Child ; Clinical Medicine - trends ; Humans ; Imaging ; Infant, Newborn ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Medicine ; Medicine & Public Health ; Minisymposium ; Neuroradiography - trends ; Neuroradiology ; Nuclear Medicine ; Oncology ; Pediatrics ; Pediatrics - trends ; Radiology ; Ultrasound ; United States</subject><ispartof>Pediatric radiology, 2010, Vol.40 (1), p.3-30, Article 3</ispartof><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-f5d05ca3a3931413f3abb1869ac6406ed475bec575c761828d1a1c7172473d2e3</citedby><cites>FETCH-LOGICAL-c402t-f5d05ca3a3931413f3abb1869ac6406ed475bec575c761828d1a1c7172473d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-009-1450-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-009-1450-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19937238$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Nelson, Marvin D.</creatorcontrib><creatorcontrib>Blüml, Stefan</creatorcontrib><title>Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Magnetic resonance spectroscopy (MRS) offers a unique, noninvasive approach to assess pediatric neurological abnormalities at microscopic levels by quantifying cellular metabolites. The most widely available MRS method, proton (
1
H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered by clinicians for pediatric neuroimaging studies if indicated. There are a multitude of both acquisition and post-processing methods that can be used in the implementation of MR spectroscopy. MRS in pediatric neuroimaging is challenging to interpret because of dramatic normal developmental changes that occur in metabolites, particularly in the first year of life. Still, MRS has been proven to provide additional clinically relevant information for several pediatric neurological disease processes such as brain tumors, infectious processes, white matter disorders, and neonatal injury. MRS can also be used as a powerful quantitative research tool. In this article, specific research applications using MRS will be demonstrated in relation to neonatal brain injury and pediatric brain tumor imaging.</description><subject>Biomarkers - analysis</subject><subject>Biomedical Research - trends</subject><subject>Brain Injuries - diagnosis</subject><subject>Brain Injuries - metabolism</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - metabolism</subject><subject>Child</subject><subject>Clinical Medicine - trends</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infant, Newborn</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minisymposium</subject><subject>Neuroradiography - trends</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Pediatrics</subject><subject>Pediatrics - trends</subject><subject>Radiology</subject><subject>Ultrasound</subject><subject>United States</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1r3DAQhkVpaDbb_oBcgumlJ6cz-rDs3EpoPiAll_QstPLsVsErOZJ92Pz6aNmFQKH0JJh55hUzD2PnCJcIoL9nAC51DdDVKBXUrx_YAqXgNXZd-5EtQADWIGV3ys5yfgYAoVB8YqelLzQX7YKZX3YTaPKuSpRjsMFRlUdyU4rZxXFX-VCN1Hs7pcIEmlNMtvdxiJvdVeUGH7yzQ2VDvw8gm9yfyo7jUKqTjyF_ZidrO2T6cnyX7PfNz6fru_rh8fb--sdD7STwqV6rHpSzwopOoESxFna1wrbprGskNNRLrVbklFZON9jytkeLTqMu-4uek1iyb4fcMcWXmfJktj47GgYbKM7ZaKk6rUSH_yeFaBuuFRTy61_kc5xTKGsYzrkG2ZYzLhkeIFculhOtzZj81qadQTB7S-ZgyRRLZm_JvJaZi2PwvNpS_z5x1FIAfgByaYUNpfef_536Bqanndg</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Panigrahy, Ashok</creator><creator>Nelson, Marvin D.</creator><creator>Blüml, Stefan</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2010</creationdate><title>Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications</title><author>Panigrahy, Ashok ; Nelson, Marvin D. ; Blüml, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-f5d05ca3a3931413f3abb1869ac6406ed475bec575c761828d1a1c7172473d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biomarkers - analysis</topic><topic>Biomedical Research - trends</topic><topic>Brain Injuries - diagnosis</topic><topic>Brain Injuries - metabolism</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - metabolism</topic><topic>Child</topic><topic>Clinical Medicine - trends</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infant, Newborn</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minisymposium</topic><topic>Neuroradiography - trends</topic><topic>Neuroradiology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Pediatrics</topic><topic>Pediatrics - trends</topic><topic>Radiology</topic><topic>Ultrasound</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Nelson, Marvin D.</creatorcontrib><creatorcontrib>Blüml, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - 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1
H; hydrogen) spectroscopy, is FDA approved for general use and can be ordered by clinicians for pediatric neuroimaging studies if indicated. There are a multitude of both acquisition and post-processing methods that can be used in the implementation of MR spectroscopy. MRS in pediatric neuroimaging is challenging to interpret because of dramatic normal developmental changes that occur in metabolites, particularly in the first year of life. Still, MRS has been proven to provide additional clinically relevant information for several pediatric neurological disease processes such as brain tumors, infectious processes, white matter disorders, and neonatal injury. MRS can also be used as a powerful quantitative research tool. In this article, specific research applications using MRS will be demonstrated in relation to neonatal brain injury and pediatric brain tumor imaging.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19937238</pmid><doi>10.1007/s00247-009-1450-z</doi><tpages>28</tpages></addata></record> |
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| subjects | Biomarkers - analysis Biomedical Research - trends Brain Injuries - diagnosis Brain Injuries - metabolism Brain Neoplasms - diagnosis Brain Neoplasms - metabolism Child Clinical Medicine - trends Humans Imaging Infant, Newborn Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Medicine Medicine & Public Health Minisymposium Neuroradiography - trends Neuroradiology Nuclear Medicine Oncology Pediatrics Pediatrics - trends Radiology Ultrasound United States |
| title | Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications |
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