Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen
We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped...
Gespeichert in:
| Veröffentlicht in: | Journal of psychopharmacology (Oxford) 2001-01, Vol.15 (1), p.61-63 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Journal of psychopharmacology (Oxford) |
| container_volume | 15 |
| creator | Turner, M. R. Gainsborough, N. |
| description | We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his clinical syndrome resulted from the sudden withdrawal of this drug. We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen. |
| doi_str_mv | 10.1177/026988110101500111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745973968</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_026988110101500111</sage_id><sourcerecordid>1980087359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-734da7504b36468e147afa2d005605d8b897476186e673c1486830906027dec3</originalsourceid><addsrcrecordid>eNp1kM1OwzAQhC0EoqXwAhxQJA6cQr2JYztHVEFBquDSe7RxnJLi_GAnqvr2uGoFFQjtYS_fzM4OIddA7wGEmNKIp1ICUD8JpQBwQsbAOIQikskpGe-AcEeMyIVza49wxpNzMgKIhOAAYzJ_1YNtje76SgU1mmrVYNOHpvrQgds2hW1rHWDZaxtgboeuDzZV_15Y3KAJ2jLIUZm21M0lOSvROH112BOyfHpczp7Dxdv8ZfawCBWLRB-KmBUoEsry2EeRGpjAEqOC0oTTpJC5TAXzySTXXMQKmOQypinlNBKFVvGE3O1tO9t-Dtr1WV05pY3BRreDywRLUhGnXjQht7_IdTvYxmfLIJWUShEnqaeiPaVs65zVZdbZqka7zYBmu5KzvyV70c3BeshrXfxIDq0e3Uan0JQWG1W5by4F5n_01HRPOVzpo3T_H_4CjjqOQQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1980087359</pqid></control><display><type>article</type><title>Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Turner, M. R. ; Gainsborough, N.</creator><creatorcontrib>Turner, M. R. ; Gainsborough, N.</creatorcontrib><description>We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his clinical syndrome resulted from the sudden withdrawal of this drug. We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen.</description><identifier>ISSN: 0269-8811</identifier><identifier>EISSN: 1461-7285</identifier><identifier>DOI: 10.1177/026988110101500111</identifier><identifier>PMID: 11277611</identifier><language>eng</language><publisher>London, Thousand Oaks, CA and New Delhi: SAGE Publications</publisher><subject>Adult ; Autonomic nervous system ; Baclofen ; Baclofen - adverse effects ; Baclofen - therapeutic use ; Biological and medical sciences ; Complications ; Creatine ; Creatine kinase ; Creatine Kinase - blood ; Disorientation ; Drug toxicity and drugs side effects treatment ; Electrocardiography - drug effects ; Humans ; Male ; Medical sciences ; Muscle Relaxants, Central - adverse effects ; Muscle Relaxants, Central - therapeutic use ; Muscle Rigidity - chemically induced ; Neuroleptic Malignant Syndrome - psychology ; Paraplegia - complications ; Pharmacology. Drug treatments ; Psychotropic drugs ; Reintroduction ; Rigidity ; Substance Withdrawal Syndrome - psychology ; Toxicity: nervous system and muscle</subject><ispartof>Journal of psychopharmacology (Oxford), 2001-01, Vol.15 (1), p.61-63</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Sage Publications Ltd. Jan 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-734da7504b36468e147afa2d005605d8b897476186e673c1486830906027dec3</citedby><cites>FETCH-LOGICAL-c427t-734da7504b36468e147afa2d005605d8b897476186e673c1486830906027dec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/026988110101500111$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/026988110101500111$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=914476$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11277611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, M. R.</creatorcontrib><creatorcontrib>Gainsborough, N.</creatorcontrib><title>Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen</title><title>Journal of psychopharmacology (Oxford)</title><addtitle>J Psychopharmacol</addtitle><description>We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his clinical syndrome resulted from the sudden withdrawal of this drug. We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen.</description><subject>Adult</subject><subject>Autonomic nervous system</subject><subject>Baclofen</subject><subject>Baclofen - adverse effects</subject><subject>Baclofen - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Complications</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Creatine Kinase - blood</subject><subject>Disorientation</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Electrocardiography - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Relaxants, Central - adverse effects</subject><subject>Muscle Relaxants, Central - therapeutic use</subject><subject>Muscle Rigidity - chemically induced</subject><subject>Neuroleptic Malignant Syndrome - psychology</subject><subject>Paraplegia - complications</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychotropic drugs</subject><subject>Reintroduction</subject><subject>Rigidity</subject><subject>Substance Withdrawal Syndrome - psychology</subject><subject>Toxicity: nervous system and muscle</subject><issn>0269-8811</issn><issn>1461-7285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1OwzAQhC0EoqXwAhxQJA6cQr2JYztHVEFBquDSe7RxnJLi_GAnqvr2uGoFFQjtYS_fzM4OIddA7wGEmNKIp1ICUD8JpQBwQsbAOIQikskpGe-AcEeMyIVza49wxpNzMgKIhOAAYzJ_1YNtje76SgU1mmrVYNOHpvrQgds2hW1rHWDZaxtgboeuDzZV_15Y3KAJ2jLIUZm21M0lOSvROH112BOyfHpczp7Dxdv8ZfawCBWLRB-KmBUoEsry2EeRGpjAEqOC0oTTpJC5TAXzySTXXMQKmOQypinlNBKFVvGE3O1tO9t-Dtr1WV05pY3BRreDywRLUhGnXjQht7_IdTvYxmfLIJWUShEnqaeiPaVs65zVZdbZqka7zYBmu5KzvyV70c3BeshrXfxIDq0e3Uan0JQWG1W5by4F5n_01HRPOVzpo3T_H_4CjjqOQQ</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Turner, M. R.</creator><creator>Gainsborough, N.</creator><general>SAGE Publications</general><general>Sage</general><general>Sage Publications Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20010101</creationdate><title>Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen</title><author>Turner, M. R. ; Gainsborough, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-734da7504b36468e147afa2d005605d8b897476186e673c1486830906027dec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Autonomic nervous system</topic><topic>Baclofen</topic><topic>Baclofen - adverse effects</topic><topic>Baclofen - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Complications</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Creatine Kinase - blood</topic><topic>Disorientation</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Electrocardiography - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Relaxants, Central - adverse effects</topic><topic>Muscle Relaxants, Central - therapeutic use</topic><topic>Muscle Rigidity - chemically induced</topic><topic>Neuroleptic Malignant Syndrome - psychology</topic><topic>Paraplegia - complications</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychotropic drugs</topic><topic>Reintroduction</topic><topic>Rigidity</topic><topic>Substance Withdrawal Syndrome - psychology</topic><topic>Toxicity: nervous system and muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, M. R.</creatorcontrib><creatorcontrib>Gainsborough, N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of psychopharmacology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turner, M. R.</au><au>Gainsborough, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen</atitle><jtitle>Journal of psychopharmacology (Oxford)</jtitle><addtitle>J Psychopharmacol</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>15</volume><issue>1</issue><spage>61</spage><epage>63</epage><pages>61-63</pages><issn>0269-8811</issn><eissn>1461-7285</eissn><abstract>We present the case of a 36-year-old man who presented with a clinically neuroleptic malignant-like syndrome involving disorientation, signs of autonomic dysfunction, rigidity and raised total creatine kinase level, but in the absence of any neuroleptic medication. He had, however, abruptly stopped taking his longterm baclofen in the days prior to presentation. He improved markedly after the reintroduction of baclofen, and we postulate that his clinical syndrome resulted from the sudden withdrawal of this drug. We concur with the concept that neuroleptic malignant syndrome represents a spectrum of disorders, and add it to the list of possible sequelae after abrupt withdrawal of baclofen.</abstract><cop>London, Thousand Oaks, CA and New Delhi</cop><pub>SAGE Publications</pub><pmid>11277611</pmid><doi>10.1177/026988110101500111</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-8811 |
| ispartof | Journal of psychopharmacology (Oxford), 2001-01, Vol.15 (1), p.61-63 |
| issn | 0269-8811 1461-7285 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_745973968 |
| source | Access via SAGE; MEDLINE |
| subjects | Adult Autonomic nervous system Baclofen Baclofen - adverse effects Baclofen - therapeutic use Biological and medical sciences Complications Creatine Creatine kinase Creatine Kinase - blood Disorientation Drug toxicity and drugs side effects treatment Electrocardiography - drug effects Humans Male Medical sciences Muscle Relaxants, Central - adverse effects Muscle Relaxants, Central - therapeutic use Muscle Rigidity - chemically induced Neuroleptic Malignant Syndrome - psychology Paraplegia - complications Pharmacology. Drug treatments Psychotropic drugs Reintroduction Rigidity Substance Withdrawal Syndrome - psychology Toxicity: nervous system and muscle |
| title | Neuroleptic malignant-like syndrome after abrupt withdrawal of baclofen |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T05%3A53%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuroleptic%20malignant-like%20syndrome%20after%20abrupt%20withdrawal%20of%20baclofen&rft.jtitle=Journal%20of%20psychopharmacology%20(Oxford)&rft.au=Turner,%20M.%20R.&rft.date=2001-01-01&rft.volume=15&rft.issue=1&rft.spage=61&rft.epage=63&rft.pages=61-63&rft.issn=0269-8811&rft.eissn=1461-7285&rft_id=info:doi/10.1177/026988110101500111&rft_dat=%3Cproquest_cross%3E1980087359%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1980087359&rft_id=info:pmid/11277611&rft_sage_id=10.1177_026988110101500111&rfr_iscdi=true |