A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin
The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32-36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This c...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1979-06, Vol.204 (4399), p.1309-1310 |
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| container_issue | 4399 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 204 |
| creator | Goldstein, Gideon Scheid, Margrit P. Boyse, Edward A. Schlesinger, David H. Van Wauwe, Jean |
| description | The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32-36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin. |
| doi_str_mv | 10.1126/science.451537 |
| format | Article |
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In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.451537</identifier><identifier>PMID: 451537</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Antigens, Surface - analysis ; B lymphocytes ; Cell Differentiation - drug effects ; Complement System Proteins ; Hormone research ; Immunocompetent cells ; Isoantigens - analysis ; Lymphocytes - cytology ; Lymphocytes - immunology ; Mice ; Mice, Nude - immunology ; Molecules ; Oligopeptides - chemical synthesis ; Oligopeptides - pharmacology ; Peptides ; Receptors, Drug - analysis ; Spleen cells ; Structure-Activity Relationship ; T lymphocytes ; Thymocytes ; Thymopoietins ; Thymopoietins - pharmacology ; Thymus hormones ; Thymus Hormones - pharmacology</subject><ispartof>Science (American Association for the Advancement of Science), 1979-06, Vol.204 (4399), p.1309-1310</ispartof><rights>Copyright 1979 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-7e08196bb5a104838ba2bcd3f2f4fc95b2bf8ace65d732cdc8232d4d4cb101163</citedby><cites>FETCH-LOGICAL-c377t-7e08196bb5a104838ba2bcd3f2f4fc95b2bf8ace65d732cdc8232d4d4cb101163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1748760$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1748760$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/451537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goldstein, Gideon</creatorcontrib><creatorcontrib>Scheid, Margrit P.</creatorcontrib><creatorcontrib>Boyse, Edward A.</creatorcontrib><creatorcontrib>Schlesinger, David H.</creatorcontrib><creatorcontrib>Van Wauwe, Jean</creatorcontrib><title>A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32-36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Antigens, Surface - analysis</subject><subject>B lymphocytes</subject><subject>Cell Differentiation - drug effects</subject><subject>Complement System Proteins</subject><subject>Hormone research</subject><subject>Immunocompetent cells</subject><subject>Isoantigens - analysis</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - immunology</subject><subject>Mice</subject><subject>Mice, Nude - immunology</subject><subject>Molecules</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptides</subject><subject>Receptors, Drug - analysis</subject><subject>Spleen cells</subject><subject>Structure-Activity Relationship</subject><subject>T lymphocytes</subject><subject>Thymocytes</subject><subject>Thymopoietins</subject><subject>Thymopoietins - pharmacology</subject><subject>Thymus hormones</subject><subject>Thymus Hormones - pharmacology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1LxDAQxYP4tX5cPXnoyYt0TZq2aY_roq4gKKjnkE6nu5G2qUlW3f_eSBcFT8Pwfu_xmCHkjNEpY0l-5UBjDzhNM5ZxsUMmjJZZXCaU75IJpTyPCyqyQ3Lk3BulQSv5Adkf6QmBWfS86f0KvYboCXuvBhy8rjH61H4VXWvTmqUG1UYz8PpD-000XymrwKPV7sdkmijYo5fVpgvbwtjO9ONqBqNDbn9C9hrVOjzdzmPyenvzMl_ED4939_PZQwxcCB8LpAUr86rKFKNpwYtKJRXUvEmatIEyq5KqKRRgntWCJ1BDkfCkTusUKkYZy_kxuRhzB2ve1-i87LQDbFvVo1k7KdKsFJQWAbwcwaVqUeoeTO_xy4NpW1yiDKXmj3LGOAswDfR0pMEa5yw2crC6U3YjGZU_L5DbF8jxqMFwvu2xrjqsf_H_8pvzxv6FibQQOeXfPgmNkg</recordid><startdate>19790622</startdate><enddate>19790622</enddate><creator>Goldstein, Gideon</creator><creator>Scheid, Margrit P.</creator><creator>Boyse, Edward A.</creator><creator>Schlesinger, David H.</creator><creator>Van Wauwe, Jean</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19790622</creationdate><title>A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin</title><author>Goldstein, Gideon ; Scheid, Margrit P. ; Boyse, Edward A. ; Schlesinger, David H. ; Van Wauwe, Jean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-7e08196bb5a104838ba2bcd3f2f4fc95b2bf8ace65d732cdc8232d4d4cb101163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Antigens, Surface - analysis</topic><topic>B lymphocytes</topic><topic>Cell Differentiation - drug effects</topic><topic>Complement System Proteins</topic><topic>Hormone research</topic><topic>Immunocompetent cells</topic><topic>Isoantigens - analysis</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - immunology</topic><topic>Mice</topic><topic>Mice, Nude - immunology</topic><topic>Molecules</topic><topic>Oligopeptides - chemical synthesis</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptides</topic><topic>Receptors, Drug - analysis</topic><topic>Spleen cells</topic><topic>Structure-Activity Relationship</topic><topic>T lymphocytes</topic><topic>Thymocytes</topic><topic>Thymopoietins</topic><topic>Thymopoietins - pharmacology</topic><topic>Thymus hormones</topic><topic>Thymus Hormones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldstein, Gideon</creatorcontrib><creatorcontrib>Scheid, Margrit P.</creatorcontrib><creatorcontrib>Boyse, Edward A.</creatorcontrib><creatorcontrib>Schlesinger, David H.</creatorcontrib><creatorcontrib>Van Wauwe, Jean</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldstein, Gideon</au><au>Scheid, Margrit P.</au><au>Boyse, Edward A.</au><au>Schlesinger, David H.</au><au>Van Wauwe, Jean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1979-06-22</date><risdate>1979</risdate><volume>204</volume><issue>4399</issue><spage>1309</spage><epage>1310</epage><pages>1309-1310</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>The pentapeptide arginyl-lysyl-aspartyl-valyl-tyrosine, corresponding to amino acid residues 32-36 in thymopoietin, was synthesized. In vitro, this pentapeptide induced the differentiation of murine prothymocytes to thymocytes and inhibited differentiative induction of cells of the B lineage. This combination of actions is presently unique to the parent molecule thymopoietin. In vivo, the pentapeptide reduced the high numbers of autologous rosette-forming cells normally present in the spleens of athymic mice; this also is a property of thymopoietin. These results suggest that this readily synthesized pentapeptide corresponds to an active site of thymopoietin and might serve as a therapeutic substitute for thymopoietin.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>451537</pmid><doi>10.1126/science.451537</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1979-06, Vol.204 (4399), p.1309-1310 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amino Acid Sequence Amino acids Animals Antigens, Surface - analysis B lymphocytes Cell Differentiation - drug effects Complement System Proteins Hormone research Immunocompetent cells Isoantigens - analysis Lymphocytes - cytology Lymphocytes - immunology Mice Mice, Nude - immunology Molecules Oligopeptides - chemical synthesis Oligopeptides - pharmacology Peptides Receptors, Drug - analysis Spleen cells Structure-Activity Relationship T lymphocytes Thymocytes Thymopoietins Thymopoietins - pharmacology Thymus hormones Thymus Hormones - pharmacology |
| title | A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone Thymopoietin |
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