Immune depression in trypanosome‐infected mice. III. Suppressor cells
Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allo...
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| Veröffentlicht in: | European journal of immunology 1979-03, Vol.9 (3), p.200-204 |
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| container_title | European journal of immunology |
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| creator | Pearson, Terry W. Roelants, Georges E. Pinder, Margaret Lundin, Lena B. Mayor‐Withey, Kathleen S. |
| description | Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allogeneic and syngeneic to the suppressors were inhibited. Irradiation or mitomycin C treatment of suppressor populations markedly reduced but did not eliminate suppressor activity. Suppressor populations were effective when present in very low numbers. Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type. |
| doi_str_mv | 10.1002/eji.1830090306 |
| format | Article |
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Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830090306</identifier><identifier>PMID: 156120</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; Antilymphocyte Serum - pharmacology ; Cell Separation ; Concanavalin A - pharmacology ; Female ; Immunosuppression ; Lipopolysaccharides - pharmacology ; Lymphocyte Culture Test, Mixed ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C3H ; Mice, Inbred CBA ; Spleen - immunology ; T-Lymphocytes - immunology ; Trypanosomiasis - immunology</subject><ispartof>European journal of immunology, 1979-03, Vol.9 (3), p.200-204</ispartof><rights>Copyright © 1979 WILEY‐VCH Verlag GmbH & Co. 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III. Suppressor cells</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allogeneic and syngeneic to the suppressors were inhibited. Irradiation or mitomycin C treatment of suppressor populations markedly reduced but did not eliminate suppressor activity. Suppressor populations were effective when present in very low numbers. Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type.</description><subject>Animals</subject><subject>Antilymphocyte Serum - pharmacology</subject><subject>Cell Separation</subject><subject>Concanavalin A - pharmacology</subject><subject>Female</subject><subject>Immunosuppression</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Inbred CBA</subject><subject>Spleen - immunology</subject><subject>T-Lymphocytes - immunology</subject><subject>Trypanosomiasis - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi3ErRRWJoZMbAm-JvWIqlKCKjEAs5XYx5Kr3LAboW48Qp-RJyG9SGVjOsP__Z-OfoRuCU4IxvQBli4hE4axxAynJ2hEBCUxJ5ycohHGhMdUTvAlugphiQcqFfICnROREopHaJ7Xdd9AZKDzEIJrm8g10cqvu6JpQ1vDz_fGNRb0CkxUOw1JlOd5Er313a7Q-khDVYVrdGaLKsDN4Y7Rx9PsffocL17n-fRxEWsqeBpnoK0FabSmmgsudGFMAYKarCypBmqBEFsKS2VGrdHAZCkwE0UmmWETqdkY3e-9nW8_ewgrVbuw_aBooO2DyriQqWR8AJM9qH0bggerOu_qwq8VwWo7nBqGU8fhhsLdwdyXNZgjvltqiOU-_nIVrP-RqdlL_kf9C_Tze6Y</recordid><startdate>197903</startdate><enddate>197903</enddate><creator>Pearson, Terry W.</creator><creator>Roelants, Georges E.</creator><creator>Pinder, Margaret</creator><creator>Lundin, Lena B.</creator><creator>Mayor‐Withey, Kathleen S.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197903</creationdate><title>Immune depression in trypanosome‐infected mice. III. Suppressor cells</title><author>Pearson, Terry W. ; Roelants, Georges E. ; Pinder, Margaret ; Lundin, Lena B. ; Mayor‐Withey, Kathleen S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2546-7ecffe9dcc2c4545caddae52d7bb2ce2fe11fb5f2972fdce39b5035a793d389c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>Antilymphocyte Serum - pharmacology</topic><topic>Cell Separation</topic><topic>Concanavalin A - pharmacology</topic><topic>Female</topic><topic>Immunosuppression</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Inbred CBA</topic><topic>Spleen - immunology</topic><topic>T-Lymphocytes - immunology</topic><topic>Trypanosomiasis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pearson, Terry W.</creatorcontrib><creatorcontrib>Roelants, Georges E.</creatorcontrib><creatorcontrib>Pinder, Margaret</creatorcontrib><creatorcontrib>Lundin, Lena B.</creatorcontrib><creatorcontrib>Mayor‐Withey, Kathleen S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pearson, Terry W.</au><au>Roelants, Georges E.</au><au>Pinder, Margaret</au><au>Lundin, Lena B.</au><au>Mayor‐Withey, Kathleen S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune depression in trypanosome‐infected mice. III. Suppressor cells</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1979-03</date><risdate>1979</risdate><volume>9</volume><issue>3</issue><spage>200</spage><epage>204</epage><pages>200-204</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Spleen cells from trypanosome‐infected mice strongly suppressed lymphocyte stimulation induced in normal spleen cell populations by lipopolysaccharide, concanavalin A or allogeneic (H‐2‐different) stimulator cells. This suppression was not H‐2‐restricted, as responses of spleen lymphocytes both allogeneic and syngeneic to the suppressors were inhibited. Irradiation or mitomycin C treatment of suppressor populations markedly reduced but did not eliminate suppressor activity. Suppressor populations were effective when present in very low numbers. Addition of suppressor cells to mixed lymphocyte cultures at various intervals after initiation of the cultures showed that the suppressors require 48 h to manifest their activity. Cell depletion or enrichment experiments indicate that the mechanism of suppression is complex and involves more than one cell type.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>156120</pmid><doi>10.1002/eji.1830090306</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1979-03, Vol.9 (3), p.200-204 |
| issn | 0014-2980 1521-4141 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Animals Antilymphocyte Serum - pharmacology Cell Separation Concanavalin A - pharmacology Female Immunosuppression Lipopolysaccharides - pharmacology Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred CBA Spleen - immunology T-Lymphocytes - immunology Trypanosomiasis - immunology |
| title | Immune depression in trypanosome‐infected mice. III. Suppressor cells |
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