Different responses in transformation of MDCK cells in 2D and 3D culture by v-Src as revealed by microarray techniques, RT-PCR and functional assays

Differentiation and transformation of untransformed and ts-Src-transformed canine kidney MDCK cells in 2D and 3D environment were investigated using microarray technique, RT-PCR, confocal microscopy and functional assays. Activated Src induced epithelial–mesenchymal transition (EMT) in 2D environmen...

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Veröffentlicht in:	Laboratory investigation 2010-06, Vol.90 (6), p.915-928
Hauptverfasser:	Töyli, Mira, Rosberg-Kulha, Linda, Capra, Janne, Vuoristo, Jussi, Eskelinen, Sinikka
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1407/651 631/208/199 631/80/82/23 631/80/84/2176 Animals apoptosis Biological and medical sciences Biotechnology Cadherins - genetics catenins Cell Cycle Cell Division Cell Line Dogs E-cadherin epithelial–mesenchymal transition Fundamental and applied biological sciences. Psychology Investigative techniques, diagnostic techniques (general aspects) Kidney - cytology Kidney - drug effects Kidney - physiology Laboratory Medicine Medical sciences Medicine Medicine & Public Health Microscopy, Confocal Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - immunology Oligonucleotide Array Sequence Analysis Oncogene Protein pp60(v-src) - pharmacology Pathology proliferation Rabbits research-article Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tight Junctions - physiology
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