Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38a Map Kinase and Map Kinase-Activated Protein Kinase-2 (MK2) Inhibitors in the Dog

Exposure to moderately selective p38a mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild clinical signs (decreased activity, diarrhea, and fever), lymphoid necrosis and depletion in the gut-associated lymphoid tissue (GALT), mesenteri...

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Veröffentlicht in:	Toxicologic pathology 2010-06, Vol.38 (4), p.606-618
Hauptverfasser:	Morris, Dale L, O'Neil, Shawn P, Devraj, Rajesh V, Portanova, Joseph P, Gilles, Richard W, Gross, Cindy J, Curtiss, Sandra W, Komocsar, Wendy J, Garner, Debra S, Happa, Fernando A, Kraus, Lori J, Nikula, Kristen J, Monahan, Joseph B, Selness, Shaun R, Galluppi, Gerald R, Shevlin, Kimberly M, Kramer, Jeffrey A, Walker, John K, Messing, Dean M, Anderson, David R, Mourey, Robert J, Whiteley, Laurence O, Daniels, John S, Yang, Jerry Z, Rowlands, Philip C, Alden, Carl L, Davis, John W, Sagartz, John E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute toxicity Apoptosis Cecum Colon Cynomolgus Diarrhea Fever Gut-associated lymphoid tissues Hemorrhage Inflammation Leukocytes (neutrophilic) Lymph nodes Lymphocytes MAP kinase Mucosa Necrosis Signal transduction Spleen
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