Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan
An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2010-04, Vol.53 (4), p.425-439 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | CHEN, Yen-Ju HUANG, Yu-Huei CHUANG, Shao-Yuan KAO, Diana Yu-Ting LAN, Yu-Ching YANG, Jyh-Yuan CHEN, Yi-Ming Arthur |
| description | An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005.
Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07_BC infection.
A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07_BC, subtype B, and CRF01_AE, respectively. Besides CRF07_BC, a new outbreak of CRF01_AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07_BC infection.
Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately. |
| doi_str_mv | 10.1097/QAI.0b013e3181ccba1a |
| format | Article |
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Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07_BC infection.
A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07_BC, subtype B, and CRF01_AE, respectively. Besides CRF07_BC, a new outbreak of CRF01_AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07_BC infection.
Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0b013e3181ccba1a</identifier><identifier>PMID: 20130472</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Biological and medical sciences ; Case-Control Studies ; Drug use ; Drug Users ; env Gene Products, Human Immunodeficiency Virus - genetics ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV Infections - complications ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; HIV-1 - isolation & purification ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Injections ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Molecular Epidemiology ; Molecular Sequence Data ; Phylogeny ; Polymerase Chain Reaction ; Prisoners ; Risk Factors ; Sequence Analysis, DNA ; Substance Abuse, Intravenous - complications ; Taiwan - epidemiology ; Viral diseases ; Viral infections ; Virology ; Young Adult</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2010-04, Vol.53 (4), p.425-439</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Apr 1, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ed5ceec4ab1dc882bdc246922ce8ab101335031c320fad4baf4b13cabec175eb3</citedby><cites>FETCH-LOGICAL-c441t-ed5ceec4ab1dc882bdc246922ce8ab101335031c320fad4baf4b13cabec175eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22546371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20130472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, Yen-Ju</creatorcontrib><creatorcontrib>HUANG, Yu-Huei</creatorcontrib><creatorcontrib>CHUANG, Shao-Yuan</creatorcontrib><creatorcontrib>KAO, Diana Yu-Ting</creatorcontrib><creatorcontrib>LAN, Yu-Ching</creatorcontrib><creatorcontrib>YANG, Jyh-Yuan</creatorcontrib><creatorcontrib>CHEN, Yi-Ming Arthur</creatorcontrib><title>Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005.
Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07_BC infection.
A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07_BC, subtype B, and CRF01_AE, respectively. Besides CRF07_BC, a new outbreak of CRF01_AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07_BC infection.
Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Drug use</subject><subject>Drug Users</subject><subject>env Gene Products, Human Immunodeficiency Virus - genetics</subject><subject>Epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Injections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Molecular Epidemiology</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Polymerase Chain Reaction</subject><subject>Prisoners</subject><subject>Risk Factors</subject><subject>Sequence Analysis, DNA</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Taiwan - epidemiology</subject><subject>Viral diseases</subject><subject>Viral infections</subject><subject>Virology</subject><subject>Young Adult</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdke1rFDEQxoMotlb_A5EgiF-6NZOXffl4Pa_tQYuorV9Dkp099thNtsktcv-90V4t9MMw8wy_Zxh4CHkP7AxYU335vlifMctAoIAanLMGzAtyDI2URVXX8mWeFVeFBKGOyJuUtoxBKWXzmhzxbGOy4sdkugkDunkwka6mvsWxD0PY7Gno6NX6VwH052x3-wnp-Sld_rhgoBerU2p8-09V-nxJ175Dt-uDp4sx-E3W24P-GucNvUsYE-09vTX9b-PfkledGRK-O_QTcnexul1eFdffLtfLxXXhpIRdga1yiE4aC62ra25bx2XZcO6wzrv8v1BMgBOcdaaV1nTSgnDGooNKoRUn5PPD3SmG-xnTTo99cjgMxmOYk66kaiTLlcmPz8htmKPPz2kuRKnKuqkzJB8gF0NKETs9xX40ca-B6b956JyHfp5Htn043J7tiO1_02MAGfh0AExyZuii8a5PTxxXshQViD8p45K3</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>CHEN, Yen-Ju</creator><creator>HUANG, Yu-Huei</creator><creator>CHUANG, Shao-Yuan</creator><creator>KAO, Diana Yu-Ting</creator><creator>LAN, Yu-Ching</creator><creator>YANG, Jyh-Yuan</creator><creator>CHEN, Yi-Ming Arthur</creator><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>20100401</creationdate><title>Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan</title><author>CHEN, Yen-Ju ; HUANG, Yu-Huei ; CHUANG, Shao-Yuan ; KAO, Diana Yu-Ting ; LAN, Yu-Ching ; YANG, Jyh-Yuan ; CHEN, Yi-Ming Arthur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ed5ceec4ab1dc882bdc246922ce8ab101335031c320fad4baf4b13cabec175eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adult</topic><topic>AIDS</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Drug use</topic><topic>Drug Users</topic><topic>env Gene Products, Human Immunodeficiency Virus - genetics</topic><topic>Epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>Human immunodeficiency virus</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Injections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Molecular Epidemiology</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Polymerase Chain Reaction</topic><topic>Prisoners</topic><topic>Risk Factors</topic><topic>Sequence Analysis, DNA</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Taiwan - epidemiology</topic><topic>Viral diseases</topic><topic>Viral infections</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEN, Yen-Ju</creatorcontrib><creatorcontrib>HUANG, Yu-Huei</creatorcontrib><creatorcontrib>CHUANG, Shao-Yuan</creatorcontrib><creatorcontrib>KAO, Diana Yu-Ting</creatorcontrib><creatorcontrib>LAN, Yu-Ching</creatorcontrib><creatorcontrib>YANG, Jyh-Yuan</creatorcontrib><creatorcontrib>CHEN, Yi-Ming Arthur</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEN, Yen-Ju</au><au>HUANG, Yu-Huei</au><au>CHUANG, Shao-Yuan</au><au>KAO, Diana Yu-Ting</au><au>LAN, Yu-Ching</au><au>YANG, Jyh-Yuan</au><au>CHEN, Yi-Ming Arthur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>53</volume><issue>4</issue><spage>425</spage><epage>439</epage><pages>425-439</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005.
Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07_BC infection.
A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07_BC, subtype B, and CRF01_AE, respectively. Besides CRF07_BC, a new outbreak of CRF01_AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07_BC infection.
Sharing dissolved heroine solution is a neglected risk factor associated with HIV-1 infection and it should be emphasized in the AIDS education and harm reduction programs immediately.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>20130472</pmid><doi>10.1097/QAI.0b013e3181ccba1a</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adult AIDS Biological and medical sciences Case-Control Studies Drug use Drug Users env Gene Products, Human Immunodeficiency Virus - genetics Epidemiology Fundamental and applied biological sciences. Psychology HIV HIV Infections - complications HIV Infections - virology HIV-1 - classification HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Injections Male Medical sciences Microbiology Middle Aged Miscellaneous Molecular Epidemiology Molecular Sequence Data Phylogeny Polymerase Chain Reaction Prisoners Risk Factors Sequence Analysis, DNA Substance Abuse, Intravenous - complications Taiwan - epidemiology Viral diseases Viral infections Virology Young Adult |
| title | Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan |
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