MYC as a regulator of ribosome biogenesis and protein synthesis

Recently, MYC has been shown to serve as a direct regulator of ribosome biogenesis and therefore coordinates protein synthesis. Could the regulation of ribosome biogenesis by MYC be necessary for its role in tumorigenesis? MYC regulates the transcription of thousands of genes required to coordinate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Cancer 2010-04, Vol.10 (4), p.301-309
Hauptverfasser:	Felsher, Dean W, van Riggelen, Jan, Yetil, Alper
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/337/574/1789 631/45/612/822 692/420/755 Biomedical and Life Sciences Biomedicine Cancer Cancer Research Gene Expression Regulation Genes, myc Genetic aspects Homeostasis Humans Models, Genetic Neoplasms - genetics opinion-2 Physiological aspects Protein Biosynthesis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Ribosomal Proteins - genetics Ribosomes Ribosomes - metabolism Ribosomes - physiology RNA, Messenger - genetics Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!