Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii -infected mice by DNA vaccination with T. gondii -derived heat shock protein 70 gene

Abstract Toxoplasma gondii -derived heat shock protein 70 ( T.g. HSP70) was proven to induce lethal anaphylactic reaction in T. gondii -infected mice through platelet-activating factor (PAF)-mediated, but not classical IgE-dependent, pathway via TLR4/MyD88 signal pathway. The effector cells generati...

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Veröffentlicht in:	Parasitology international 2010-06, Vol.59 (2), p.105-111
Hauptverfasser:	Kikumura, Akitoshi, Fang, Hao, Mun, Hye-Seong, Uemura, Noriko, Makino, Masayuki, Sayama, Yusuke, Norose, Kazumi, Aosai, Fumie
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylactic reaction Anaphylaxis - immunology Anaphylaxis - prevention & control Animals Antigens, Protozoan - genetics Antigens, Protozoan - immunology DNA, Protozoan - genetics DNA, Protozoan - immunology Female Gastroenterology and Hepatology HSP70 Heat-Shock Proteins - administration & dosage HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - immunology Infectious Disease Mice Mice, Inbred C57BL Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Vaccines - administration & dosage Protozoan Vaccines - genetics Protozoan Vaccines - immunology T.g.HSP70 gene vaccine Toxoplasma Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - prevention & control Vaccination - methods Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology
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