Genotype Frequencies of Selected Drug Metabolizing Enzymes and ABC Drug Transporters among Breast Cancer Patients on FAC Chemotherapy

: Polymorphic genes of drug metabolizing enzymes and transporters may influence drug response. With some exemptions, single nucleotide polymorphisms in such genes, however, are not known to be susceptibility factors for breast cancer. This study explored genotype profiles for the breast cancer pati...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2010-07, Vol.107 (1), p.570-576
Hauptverfasser:	Afsar, Nasir Ali, Haenisch, Sierk, Mateen, Ahmed, Usman, Ahmed, Ufer, Mike, Ahmed, Khwaja Zafar, Ahmad, Hakimuddin Razi, Cascorbi, Ingolf
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporter Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Aryl Hydrocarbon Hydroxylases - metabolism ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Chemotherapy Continental Population Groups - genetics Cyclophosphamide Cyclophosphamide - pharmacokinetics Cyclophosphamide - therapeutic use Cytochrome P-450 CYP2C9 Data processing Detoxification DNA Mutational Analysis Doxorubicin Doxorubicin - pharmacokinetics Doxorubicin - therapeutic use Enzymes Female Fluorouracil - pharmacokinetics Fluorouracil - therapeutic use Gene Frequency Genotype Genotyping Glutathione Transferase - genetics Glutathione Transferase - metabolism Gynecology. Andrology. Obstetrics Humans Inactivation, Metabolic Mammary gland diseases Medical sciences Pakistan Pharmacology. Drug treatments Polymorphism, Genetic Polymorphism, Restriction Fragment Length Restriction fragment length polymorphism Risk factors Single-nucleotide polymorphism Statistics Tumors
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