Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter

To date, acetylcholinesterase (AChE) inhibitors have been clinically effective drugs for the palliative treatment of Alzheimer's disease, but their clinical efficacy is limited, mainly due to their adverse effects on peripheral organs. Since patients of Alzheimer's disease often exhibit de...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2010/03/01, Vol.58(3), pp.273-287
Hauptverfasser:	Toda, Narihiro, Kaneko, Tsugio, Kogen, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer's disease Animals Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Drug Design dual inhibitor Humans Serotonin Plasma Membrane Transport Proteins - metabolism serotonin transporter Serotonin Uptake Inhibitors - chemical synthesis Serotonin Uptake Inhibitors - chemistry Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use
Online-Zugang:	Volltext
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