Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

Polycomb group (PcG) proteins are essential regulators of stem cells. PcG and trithorax group proteins mark developmental regulator gene promoters with bivalent domains consisting of overlapping repressive and activating histone modifications to keep them poised for activation in embryonic stem cell...

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Veröffentlicht in:	Cell stem cell 2010-03, Vol.6 (3), p.279-286
Hauptverfasser:	Oguro, Hideyuki, Yuan, Jin, Ichikawa, Hitoshi, Ikawa, Tomokatsu, Yamazaki, Satoshi, Kawamoto, Hiroshi, Nakauchi, Hiromitsu, Iwama, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - metabolism Biological and medical sciences Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell Lineage Cell physiology Cells, Cultured Fundamental and applied biological sciences. Psychology Gene Expression Profiling Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular and cellular biology Multipotent Stem Cells - cytology Multipotent Stem Cells - metabolism Nuclear Proteins - deficiency Nuclear Proteins - metabolism PAX5 Transcription Factor - deficiency PAX5 Transcription Factor - metabolism Polycomb Repressive Complex 1 Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - metabolism Repressor Proteins - deficiency Repressor Proteins - metabolism STEMCELL Trans-Activators - deficiency Trans-Activators - metabolism
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