Immunoglobulin G from Patients with Graves’ Disease Induces Interleukin-16 and RANTES Expression in Cultured Human Thyrocytes: A Putative Mechanism for T-Cell Infiltration of the Thyroid in Autoimmune Disease

Mechanisms underlying lymphocyte infiltration of the thyroid gland and orbit in Graves’ disease (GD) are poorly understood. The IGF-I receptor (IGF-IR) is a newly recognized self-antigen that, when activated in GD fibroblasts by IGF-I or GD-IgGs, provokes the expression of IL-16 and RANTES (regulate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrinology (Philadelphia) 2006-04, Vol.147 (4), p.1941-1949
Hauptverfasser:	Gianoukakis, Andrew G, Douglas, Raymond S, King, Chris S, Cruikshank, William W, Smith, Terry J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Autoantigens Autoimmune diseases Autoimmune Diseases - pathology CD4 antigen Cell activation Cell Movement Cells, Cultured Chemokine CCL5 - genetics Chemotactic factors Dexamethasone Dexamethasone - pharmacology Graves disease Graves Disease - immunology Humans Hyaluronic acid IgG antibody Immunoglobulin G Immunoglobulin G - pharmacology Infiltration Insulin-like growth factor I Insulin-like growth factor I receptors Interleukin 16 Interleukin-16 - genetics Lymphocytes Lymphocytes T Monoclonal antibodies RANTES Rapamycin Receptor, IGF Type 1 - analysis Receptors Receptors, Thyrotropin - analysis RNA, Messenger - analysis Sirolimus - pharmacology Synthesis T-Lymphocytes - physiology Thyrocytes Thyroid Thyroid gland Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid-stimulating hormone TOR protein Transcription
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!