Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation
Post-processing drug impregnation of commercially available polymer-based devices is a recent and attractive approach for the development of multifunctional biomedical devices and implants, drug release systems and tissue scaffolds. Therapeutic ophthalmic articles, such as drug-loaded contact lenses...
Gespeichert in:
Veröffentlicht in: | The Journal of supercritical fluids 2010-06, Vol.53 (1), p.165-173 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 173 |
---|---|
container_issue | 1 |
container_start_page | 165 |
container_title | The Journal of supercritical fluids |
container_volume | 53 |
creator | Costa, Viviana P. Braga, Mara E.M. Duarte, Catarina M.M. Alvarez-Lorenzo, Carmen Concheiro, Angel Gil, Maria H. de Sousa, Hermínio C. |
description | Post-processing drug impregnation of commercially available polymer-based devices is a recent and attractive approach for the development of multifunctional biomedical devices and implants, drug release systems and tissue scaffolds. Therapeutic ophthalmic articles, such as drug-loaded contact lenses, are already known to improve ocular bioavailability in the treatment of several eye diseases, namely glaucoma, as well as to minimize undesired systemic side-effects. In this work, commercial silicone-based hydrogel contact lenses (Balafilcon A) were impregnated with two anti-glaucoma drugs (acetazolamide and timolol maleate) using a discontinuous supercritical solvent impregnation (SSI) methodology. Pressure and temperature, as well as impregnation time and depressurization rate, were kept constant (17
MPa, 40
°C, 90
min, 0.06
MPa/min, respectively) in order to evaluate the effects of nature and concentration of cosolvents (ethanol and water at 5, 10 and 15% molar) on the impregnation efficiencies and the properties of the contact lenses. Glass-transition temperature (DSC), oxygen permeability, contact angle, apparent morphological changes (SEM) and
in vitro drug release kinetics were studied in detail. Results demonstrated the feasibility of preparing acetazolamide and timolol maleate impregnated therapeutic Balafilcon A contact lenses using CO
2
+
EtOH and CO
2
+
H
2O solvent mixtures. Valuable information about how the nature and the composition of the employed solvent mixtures influence drug loading, drug release profiles and contact lenses physical and thermomechanical properties was obtained. |
doi_str_mv | 10.1016/j.supflu.2010.02.007 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_745932688</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S089684461000077X</els_id><sourcerecordid>745932688</sourcerecordid><originalsourceid>FETCH-LOGICAL-c338t-4692ccc8d7466c0c5cd4a76e9987383a2ffb75526951995b7a2b6fe995ea6e933</originalsourceid><addsrcrecordid>eNp9kE9LxDAQxYMouK5-Aw-9eeqapm2aXoRl8R8seNGLl5CdTkuWNKlJKvjtzVLPngbevPeG-RFyW9BNQQt-f9yEeerNvGE0SZRtKG3OyKoQDctFwdk5WVHR8lxUFb8kVyEcKaU1LcoV-dzaqPPBqBncqLLOz0NunOqwy8DZqCBmBm3AkE0eJ-WTPgdthyxdRA9eRw3KZMGZb7Qx02OyDVZF7ew1ueiVCXjzN9fk4-nxffeS79-eX3fbfQ5lKWJe8ZYBgOiainOgUENXqYZj24qmFKVifX9o6prxti7atj40ih14n9Y1quQqyzW5W3on775mDFGOOgAaoyy6OcimqtuScSGSs1qc4F0IHns5eT0q_yMLKk8k5VEuJOWJpKRMJpIp9rDEMH3xrdHLABotYKc9QpSd0_8X_AJhRICL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>745932688</pqid></control><display><type>article</type><title>Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation</title><source>Access via ScienceDirect (Elsevier)</source><creator>Costa, Viviana P. ; Braga, Mara E.M. ; Duarte, Catarina M.M. ; Alvarez-Lorenzo, Carmen ; Concheiro, Angel ; Gil, Maria H. ; de Sousa, Hermínio C.</creator><creatorcontrib>Costa, Viviana P. ; Braga, Mara E.M. ; Duarte, Catarina M.M. ; Alvarez-Lorenzo, Carmen ; Concheiro, Angel ; Gil, Maria H. ; de Sousa, Hermínio C.</creatorcontrib><description>Post-processing drug impregnation of commercially available polymer-based devices is a recent and attractive approach for the development of multifunctional biomedical devices and implants, drug release systems and tissue scaffolds. Therapeutic ophthalmic articles, such as drug-loaded contact lenses, are already known to improve ocular bioavailability in the treatment of several eye diseases, namely glaucoma, as well as to minimize undesired systemic side-effects. In this work, commercial silicone-based hydrogel contact lenses (Balafilcon A) were impregnated with two anti-glaucoma drugs (acetazolamide and timolol maleate) using a discontinuous supercritical solvent impregnation (SSI) methodology. Pressure and temperature, as well as impregnation time and depressurization rate, were kept constant (17
MPa, 40
°C, 90
min, 0.06
MPa/min, respectively) in order to evaluate the effects of nature and concentration of cosolvents (ethanol and water at 5, 10 and 15% molar) on the impregnation efficiencies and the properties of the contact lenses. Glass-transition temperature (DSC), oxygen permeability, contact angle, apparent morphological changes (SEM) and
in vitro drug release kinetics were studied in detail. Results demonstrated the feasibility of preparing acetazolamide and timolol maleate impregnated therapeutic Balafilcon A contact lenses using CO
2
+
EtOH and CO
2
+
H
2O solvent mixtures. Valuable information about how the nature and the composition of the employed solvent mixtures influence drug loading, drug release profiles and contact lenses physical and thermomechanical properties was obtained.</description><identifier>ISSN: 0896-8446</identifier><identifier>EISSN: 1872-8162</identifier><identifier>DOI: 10.1016/j.supflu.2010.02.007</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Acetazolamide ; Contact lenses ; Glaucoma ; Supercritical solvent impregnation (SSI) ; Timolol maleate</subject><ispartof>The Journal of supercritical fluids, 2010-06, Vol.53 (1), p.165-173</ispartof><rights>2010 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-4692ccc8d7466c0c5cd4a76e9987383a2ffb75526951995b7a2b6fe995ea6e933</citedby><cites>FETCH-LOGICAL-c338t-4692ccc8d7466c0c5cd4a76e9987383a2ffb75526951995b7a2b6fe995ea6e933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.supflu.2010.02.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Costa, Viviana P.</creatorcontrib><creatorcontrib>Braga, Mara E.M.</creatorcontrib><creatorcontrib>Duarte, Catarina M.M.</creatorcontrib><creatorcontrib>Alvarez-Lorenzo, Carmen</creatorcontrib><creatorcontrib>Concheiro, Angel</creatorcontrib><creatorcontrib>Gil, Maria H.</creatorcontrib><creatorcontrib>de Sousa, Hermínio C.</creatorcontrib><title>Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation</title><title>The Journal of supercritical fluids</title><description>Post-processing drug impregnation of commercially available polymer-based devices is a recent and attractive approach for the development of multifunctional biomedical devices and implants, drug release systems and tissue scaffolds. Therapeutic ophthalmic articles, such as drug-loaded contact lenses, are already known to improve ocular bioavailability in the treatment of several eye diseases, namely glaucoma, as well as to minimize undesired systemic side-effects. In this work, commercial silicone-based hydrogel contact lenses (Balafilcon A) were impregnated with two anti-glaucoma drugs (acetazolamide and timolol maleate) using a discontinuous supercritical solvent impregnation (SSI) methodology. Pressure and temperature, as well as impregnation time and depressurization rate, were kept constant (17
MPa, 40
°C, 90
min, 0.06
MPa/min, respectively) in order to evaluate the effects of nature and concentration of cosolvents (ethanol and water at 5, 10 and 15% molar) on the impregnation efficiencies and the properties of the contact lenses. Glass-transition temperature (DSC), oxygen permeability, contact angle, apparent morphological changes (SEM) and
in vitro drug release kinetics were studied in detail. Results demonstrated the feasibility of preparing acetazolamide and timolol maleate impregnated therapeutic Balafilcon A contact lenses using CO
2
+
EtOH and CO
2
+
H
2O solvent mixtures. Valuable information about how the nature and the composition of the employed solvent mixtures influence drug loading, drug release profiles and contact lenses physical and thermomechanical properties was obtained.</description><subject>Acetazolamide</subject><subject>Contact lenses</subject><subject>Glaucoma</subject><subject>Supercritical solvent impregnation (SSI)</subject><subject>Timolol maleate</subject><issn>0896-8446</issn><issn>1872-8162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAQxYMouK5-Aw-9eeqapm2aXoRl8R8seNGLl5CdTkuWNKlJKvjtzVLPngbevPeG-RFyW9BNQQt-f9yEeerNvGE0SZRtKG3OyKoQDctFwdk5WVHR8lxUFb8kVyEcKaU1LcoV-dzaqPPBqBncqLLOz0NunOqwy8DZqCBmBm3AkE0eJ-WTPgdthyxdRA9eRw3KZMGZb7Qx02OyDVZF7ew1ueiVCXjzN9fk4-nxffeS79-eX3fbfQ5lKWJe8ZYBgOiainOgUENXqYZj24qmFKVifX9o6prxti7atj40ih14n9Y1quQqyzW5W3on775mDFGOOgAaoyy6OcimqtuScSGSs1qc4F0IHns5eT0q_yMLKk8k5VEuJOWJpKRMJpIp9rDEMH3xrdHLABotYKc9QpSd0_8X_AJhRICL</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Costa, Viviana P.</creator><creator>Braga, Mara E.M.</creator><creator>Duarte, Catarina M.M.</creator><creator>Alvarez-Lorenzo, Carmen</creator><creator>Concheiro, Angel</creator><creator>Gil, Maria H.</creator><creator>de Sousa, Hermínio C.</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20100601</creationdate><title>Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation</title><author>Costa, Viviana P. ; Braga, Mara E.M. ; Duarte, Catarina M.M. ; Alvarez-Lorenzo, Carmen ; Concheiro, Angel ; Gil, Maria H. ; de Sousa, Hermínio C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-4692ccc8d7466c0c5cd4a76e9987383a2ffb75526951995b7a2b6fe995ea6e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetazolamide</topic><topic>Contact lenses</topic><topic>Glaucoma</topic><topic>Supercritical solvent impregnation (SSI)</topic><topic>Timolol maleate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costa, Viviana P.</creatorcontrib><creatorcontrib>Braga, Mara E.M.</creatorcontrib><creatorcontrib>Duarte, Catarina M.M.</creatorcontrib><creatorcontrib>Alvarez-Lorenzo, Carmen</creatorcontrib><creatorcontrib>Concheiro, Angel</creatorcontrib><creatorcontrib>Gil, Maria H.</creatorcontrib><creatorcontrib>de Sousa, Hermínio C.</creatorcontrib><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Journal of supercritical fluids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costa, Viviana P.</au><au>Braga, Mara E.M.</au><au>Duarte, Catarina M.M.</au><au>Alvarez-Lorenzo, Carmen</au><au>Concheiro, Angel</au><au>Gil, Maria H.</au><au>de Sousa, Hermínio C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation</atitle><jtitle>The Journal of supercritical fluids</jtitle><date>2010-06-01</date><risdate>2010</risdate><volume>53</volume><issue>1</issue><spage>165</spage><epage>173</epage><pages>165-173</pages><issn>0896-8446</issn><eissn>1872-8162</eissn><abstract>Post-processing drug impregnation of commercially available polymer-based devices is a recent and attractive approach for the development of multifunctional biomedical devices and implants, drug release systems and tissue scaffolds. Therapeutic ophthalmic articles, such as drug-loaded contact lenses, are already known to improve ocular bioavailability in the treatment of several eye diseases, namely glaucoma, as well as to minimize undesired systemic side-effects. In this work, commercial silicone-based hydrogel contact lenses (Balafilcon A) were impregnated with two anti-glaucoma drugs (acetazolamide and timolol maleate) using a discontinuous supercritical solvent impregnation (SSI) methodology. Pressure and temperature, as well as impregnation time and depressurization rate, were kept constant (17
MPa, 40
°C, 90
min, 0.06
MPa/min, respectively) in order to evaluate the effects of nature and concentration of cosolvents (ethanol and water at 5, 10 and 15% molar) on the impregnation efficiencies and the properties of the contact lenses. Glass-transition temperature (DSC), oxygen permeability, contact angle, apparent morphological changes (SEM) and
in vitro drug release kinetics were studied in detail. Results demonstrated the feasibility of preparing acetazolamide and timolol maleate impregnated therapeutic Balafilcon A contact lenses using CO
2
+
EtOH and CO
2
+
H
2O solvent mixtures. Valuable information about how the nature and the composition of the employed solvent mixtures influence drug loading, drug release profiles and contact lenses physical and thermomechanical properties was obtained.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.supflu.2010.02.007</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0896-8446 |
ispartof | The Journal of supercritical fluids, 2010-06, Vol.53 (1), p.165-173 |
issn | 0896-8446 1872-8162 |
language | eng |
recordid | cdi_proquest_miscellaneous_745932688 |
source | Access via ScienceDirect (Elsevier) |
subjects | Acetazolamide Contact lenses Glaucoma Supercritical solvent impregnation (SSI) Timolol maleate |
title | Anti-glaucoma drug-loaded contact lenses prepared using supercritical solvent impregnation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T01%3A22%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-glaucoma%20drug-loaded%20contact%20lenses%20prepared%20using%20supercritical%20solvent%20impregnation&rft.jtitle=The%20Journal%20of%20supercritical%20fluids&rft.au=Costa,%20Viviana%20P.&rft.date=2010-06-01&rft.volume=53&rft.issue=1&rft.spage=165&rft.epage=173&rft.pages=165-173&rft.issn=0896-8446&rft.eissn=1872-8162&rft_id=info:doi/10.1016/j.supflu.2010.02.007&rft_dat=%3Cproquest_cross%3E745932688%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=745932688&rft_id=info:pmid/&rft_els_id=S089684461000077X&rfr_iscdi=true |