In a randomized, double-blinded, placebo-controlled trial, the single oral dose typhoid vaccine, M01ZH09, is safe and immunogenic at doses up to 1.7 x 10 super(10) colony-forming units

M01ZH09, S. Typhi (Ty2aroCssaV) ZH9, is a single oral dose typhoid vaccine with independently attenuating deletions. A phase II randomized, double-blind, placebo-controlled, dose-escalating trial evaluated the safety and immunogenicity of M01ZH09 to 1.7 x 10 super(10) colony-forming units (CFU). 187...

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Veröffentlicht in:Vaccine 2010-04, Vol.28 (20), p.3602-3608
Hauptverfasser: Lyon, CE, Sadigh, K S, Carmolli, M P, Harro, C, Sheldon, E, Lindow, J C, Larsson, C J, Martinez, T, Feller, A, Ventrone, CH, Sack, DA, DeNearing, B, Fingar, A, Pierce, K, Dill, E A, Schwartz, H I, Beardsworth, EE, Kilonzo, B, May, J P, Lam, W, Upton, A, Budhram, R, Kirkpatrick, B D
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Sprache:eng
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