Abacavir-induced agranulocytosis in two Taiwanese patients tested HLA-B5701-negative

Abacavir, a nucleoside reverse transcriptase inhibitor, is associated with hypersensitivity reactions (ABC HSR) in 5--8% of white patients infected with HIV-1 [1,2]. Such reactions usually occur within the first 6 weeks of abacavir treatment and are characterized by multisystem involvement [2]. Disc...

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Veröffentlicht in:	AIDS (London) 2010-05, Vol.24 (8), p.1238-1239
Hauptverfasser:	CHEN, Su-Jung, YANG, Su-Pen, HUNG, Chien-Chung, FUNG, Chang-Phone
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - adverse effects Antiviral agents Biological and medical sciences Dideoxynucleosides - adverse effects Drug Hypersensitivity - genetics Hematologic and hematopoietic diseases HIV Infections - complications HIV Infections - drug therapy HLA-B Antigens - drug effects Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Other diseases. Hematologic involvement in other diseases Pharmacology. Drug treatments Reverse Transcriptase Inhibitors - adverse effects Taiwan Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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