Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice
The aim of this study was to investigate the effect of long-term nutrient intake on the central response to the anorexigenic gut hormone CCK. C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to ch...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-05, Vol.50 (4), p.1560-1565 |
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| creator | Zeeni, N. Nadkarni, N. Bell, J.D. Even, P.C. Fromentin, G. Tome, D. Darcel, N. |
| description | The aim of this study was to investigate the effect of long-term nutrient intake on the central response to the anorexigenic gut hormone CCK. C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with reward (nucleus accumbens and striatum) regardless of diet. When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. Our results put forward that the long-term intake of an HP diet leads to a reduction in basal hypothalamic activation while a high-fat diet leads to desensitization to CCK-induced effects in the hypothalamus. |
| doi_str_mv | 10.1016/j.neuroimage.2010.01.065 |
| format | Article |
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C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with reward (nucleus accumbens and striatum) regardless of diet. When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. Our results put forward that the long-term intake of an HP diet leads to a reduction in basal hypothalamic activation while a high-fat diet leads to desensitization to CCK-induced effects in the hypothalamus.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2010.01.065</identifier><identifier>PMID: 20100582</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain - drug effects ; Brain - physiology ; Brain Mapping ; Carbohydrates ; Cholagogues and Choleretics - administration & dosage ; Cholagogues and Choleretics - pharmacology ; Cholecystokinin ; Cholecystokinin - administration & dosage ; Cholecystokinin - pharmacology ; Diet ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dietary Proteins - administration & dosage ; Food ; Gut–brain axis ; High-fat diet ; High-protein diet ; Hypothalamic Area, Lateral - drug effects ; Hypothalamic Area, Lateral - physiology ; Magnetic Resonance Imaging - methods ; Male ; Manganese Compounds ; Manganese-enhanced magnetic resonance imaging (MEMRI) ; Mice ; Mice, Inbred C57BL ; Nervous system ; Neural networks ; NMR ; Nuclear magnetic resonance ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - physiology ; Proteins ; Random Allocation ; Rodents</subject><ispartof>NeuroImage (Orlando, Fla.), 2010-05, Vol.50 (4), p.1560-1565</ispartof><rights>2010 Elsevier Inc.</rights><rights>2010 Elsevier Inc. 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C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with reward (nucleus accumbens and striatum) regardless of diet. When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. Our results put forward that the long-term intake of an HP diet leads to a reduction in basal hypothalamic activation while a high-fat diet leads to desensitization to CCK-induced effects in the hypothalamus.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Carbohydrates</subject><subject>Cholagogues and Choleretics - administration & dosage</subject><subject>Cholagogues and Choleretics - pharmacology</subject><subject>Cholecystokinin</subject><subject>Cholecystokinin - administration & dosage</subject><subject>Cholecystokinin - pharmacology</subject><subject>Diet</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Food</subject><subject>Gut–brain axis</subject><subject>High-fat diet</subject><subject>High-protein diet</subject><subject>Hypothalamic Area, Lateral - 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drug effects</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Carbohydrates</topic><topic>Cholagogues and Choleretics - administration & dosage</topic><topic>Cholagogues and Choleretics - pharmacology</topic><topic>Cholecystokinin</topic><topic>Cholecystokinin - administration & dosage</topic><topic>Cholecystokinin - pharmacology</topic><topic>Diet</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Food</topic><topic>Gut–brain axis</topic><topic>High-fat diet</topic><topic>High-protein diet</topic><topic>Hypothalamic Area, Lateral - drug effects</topic><topic>Hypothalamic Area, Lateral - physiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Manganese Compounds</topic><topic>Manganese-enhanced magnetic resonance imaging (MEMRI)</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nervous system</topic><topic>Neural networks</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Paraventricular Hypothalamic Nucleus - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeeni, N.</au><au>Nadkarni, N.</au><au>Bell, J.D.</au><au>Even, P.C.</au><au>Fromentin, G.</au><au>Tome, D.</au><au>Darcel, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>50</volume><issue>4</issue><spage>1560</spage><epage>1565</epage><pages>1560-1565</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>The aim of this study was to investigate the effect of long-term nutrient intake on the central response to the anorexigenic gut hormone CCK. C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with reward (nucleus accumbens and striatum) regardless of diet. When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. Our results put forward that the long-term intake of an HP diet leads to a reduction in basal hypothalamic activation while a high-fat diet leads to desensitization to CCK-induced effects in the hypothalamus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20100582</pmid><doi>10.1016/j.neuroimage.2010.01.065</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Brain - drug effects Brain - physiology Brain Mapping Carbohydrates Cholagogues and Choleretics - administration & dosage Cholagogues and Choleretics - pharmacology Cholecystokinin Cholecystokinin - administration & dosage Cholecystokinin - pharmacology Diet Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dietary Proteins - administration & dosage Food Gut–brain axis High-fat diet High-protein diet Hypothalamic Area, Lateral - drug effects Hypothalamic Area, Lateral - physiology Magnetic Resonance Imaging - methods Male Manganese Compounds Manganese-enhanced magnetic resonance imaging (MEMRI) Mice Mice, Inbred C57BL Nervous system Neural networks NMR Nuclear magnetic resonance Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiology Proteins Random Allocation Rodents |
| title | Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice |
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