The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan
Cytogenetic abnormalities were often observed in primary myelofibrosis patients. The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q−, 20q−, or −7/7q−, is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from...
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| Veröffentlicht in: | European journal of haematology 2009-10, Vol.83 (4), p.328-333 |
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| creator | Hidaka, Tomonori Shide, Kotaro Shimoda, Haruko Kameda, Takurou Toyama, Keiko Katayose, Keiko Kubuki, Youko Nagata, Kenji Takenaka, Katsuto Akashi, Koichi Okamura, Takashi Niho, Yoshiyuki Mizoguchi, Hideaki Omine, Mitsuhiro Ozawa, Keiya Harada, Mine Shimoda, Kazuya |
| description | Cytogenetic abnormalities were often observed in primary myelofibrosis patients. The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q−, 20q−, or −7/7q−, is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from the prospective survey of Japanese primary myelofibrosis patients which was conducted from 1999 to clarify the impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis. A total of 202 primary myelofibrosis patients had the cytogenetic and the prognostic data. Eighty (40%) out of 202 cases had cytogenetic abnormalities, and an association was evident for platelet counts. Although the presence of an abnormal karyotype did not affect the prognosis, primary myelofibrosis patients with cytogenetic abnormalities other than 13q− and 20q− showed an inferior prognosis compared to patients with a normal karyotype or sole 13q− or 20q− abnormalities. Patients with an unfavorable cytogenetic profile (abnormal cytogenetics other than 13q− or 20q−) also had a greater tendency to transform to leukemia than patients with a favorable cytogenetic profile (normal cytogenetics, sole abnormalities of either chromosome 13q−, or 20q−). Abnormal cytogenetics other than 13q− or 20q− in primary myelofibrosis patients has the poor prognostic effect for both survival and the risk of leukemic transformation. |
| doi_str_mv | 10.1111/j.1600-0609.2009.01298.x |
| format | Article |
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The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q−, 20q−, or −7/7q−, is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from the prospective survey of Japanese primary myelofibrosis patients which was conducted from 1999 to clarify the impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis. A total of 202 primary myelofibrosis patients had the cytogenetic and the prognostic data. Eighty (40%) out of 202 cases had cytogenetic abnormalities, and an association was evident for platelet counts. Although the presence of an abnormal karyotype did not affect the prognosis, primary myelofibrosis patients with cytogenetic abnormalities other than 13q− and 20q− showed an inferior prognosis compared to patients with a normal karyotype or sole 13q− or 20q− abnormalities. Patients with an unfavorable cytogenetic profile (abnormal cytogenetics other than 13q− or 20q−) also had a greater tendency to transform to leukemia than patients with a favorable cytogenetic profile (normal cytogenetics, sole abnormalities of either chromosome 13q−, or 20q−). Abnormal cytogenetics other than 13q− or 20q− in primary myelofibrosis patients has the poor prognostic effect for both survival and the risk of leukemic transformation.</description><identifier>ISSN: 0902-4441</identifier><identifier>EISSN: 1600-0609</identifier><identifier>DOI: 10.1111/j.1600-0609.2009.01298.x</identifier><identifier>PMID: 19549278</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>13q ; 20q ; 7/7q ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cell Transformation, Neoplastic - genetics ; Chromosome Aberrations ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 20 ; Chromosomes, Human, Pair 7 ; cytogenetic abnormalities ; Humans ; Japan - epidemiology ; Leukemia - etiology ; Male ; Middle Aged ; primary myelofibrosis ; Primary Myelofibrosis - diagnosis ; Primary Myelofibrosis - epidemiology ; Primary Myelofibrosis - genetics ; Prognosis ; Survival Analysis ; Young Adult</subject><ispartof>European journal of haematology, 2009-10, Vol.83 (4), p.328-333</ispartof><rights>2009 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5038-ee0f8db9bdbac71fbe8678622a1ba7076116590b97b19ac73b03d65a8211fb1b3</citedby><cites>FETCH-LOGICAL-c5038-ee0f8db9bdbac71fbe8678622a1ba7076116590b97b19ac73b03d65a8211fb1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0609.2009.01298.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0609.2009.01298.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19549278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hidaka, Tomonori</creatorcontrib><creatorcontrib>Shide, Kotaro</creatorcontrib><creatorcontrib>Shimoda, Haruko</creatorcontrib><creatorcontrib>Kameda, Takurou</creatorcontrib><creatorcontrib>Toyama, Keiko</creatorcontrib><creatorcontrib>Katayose, Keiko</creatorcontrib><creatorcontrib>Kubuki, Youko</creatorcontrib><creatorcontrib>Nagata, Kenji</creatorcontrib><creatorcontrib>Takenaka, Katsuto</creatorcontrib><creatorcontrib>Akashi, Koichi</creatorcontrib><creatorcontrib>Okamura, Takashi</creatorcontrib><creatorcontrib>Niho, Yoshiyuki</creatorcontrib><creatorcontrib>Mizoguchi, Hideaki</creatorcontrib><creatorcontrib>Omine, Mitsuhiro</creatorcontrib><creatorcontrib>Ozawa, Keiya</creatorcontrib><creatorcontrib>Harada, Mine</creatorcontrib><creatorcontrib>Shimoda, Kazuya</creatorcontrib><title>The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan</title><title>European journal of haematology</title><addtitle>Eur J Haematol</addtitle><description>Cytogenetic abnormalities were often observed in primary myelofibrosis patients. The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q−, 20q−, or −7/7q−, is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from the prospective survey of Japanese primary myelofibrosis patients which was conducted from 1999 to clarify the impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis. A total of 202 primary myelofibrosis patients had the cytogenetic and the prognostic data. Eighty (40%) out of 202 cases had cytogenetic abnormalities, and an association was evident for platelet counts. Although the presence of an abnormal karyotype did not affect the prognosis, primary myelofibrosis patients with cytogenetic abnormalities other than 13q− and 20q− showed an inferior prognosis compared to patients with a normal karyotype or sole 13q− or 20q− abnormalities. Patients with an unfavorable cytogenetic profile (abnormal cytogenetics other than 13q− or 20q−) also had a greater tendency to transform to leukemia than patients with a favorable cytogenetic profile (normal cytogenetics, sole abnormalities of either chromosome 13q−, or 20q−). Abnormal cytogenetics other than 13q− or 20q− in primary myelofibrosis patients has the poor prognostic effect for both survival and the risk of leukemic transformation.</description><subject>13q</subject><subject>20q</subject><subject>7/7q</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Chromosomes, Human, Pair 20</subject><subject>Chromosomes, Human, Pair 7</subject><subject>cytogenetic abnormalities</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Leukemia - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>primary myelofibrosis</subject><subject>Primary Myelofibrosis - diagnosis</subject><subject>Primary Myelofibrosis - epidemiology</subject><subject>Primary Myelofibrosis - genetics</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Young Adult</subject><issn>0902-4441</issn><issn>1600-0609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokPhLyCvYJXptZP4gcQCVX2qPCQGdWnZnpviIa_GmTJZ8N9xmFHZIbywLd3vnHvtQwhlsGRpnWyWTABkIEAvOaQNGNdquXtCFo-Fp2QBGnhWFAU7Ii9i3AAA10w-J0dMl4XmUi3Ir9V3pKHprR9pV1E_jd0dtjgGT61ru6GxdRgDRtq1dExoP3R3bRdDnOl-CI0dJtpMWHdVcMNceEftTMUe_RgekMbt8IDTjHPg1NuYzEJLr21v25fkWWXriK8O5zH5dn62Or3Mbj5fXJ1-uMl8CbnKEKFSa6fd2lkvWeVQCakE55Y5K0EKxkSpwWnpmE5E7iBfi9IqzhLMXH5M3u5902D3W4yjaUL0WNe2xW4bjSxKzbWAPJFv_kkKKUqhFUug2oM-vTUOWJnDbxgGZg7JbMychZmzMHNI5k9IZpekrw89tq7B9V_hIZUEvN8DP0ON038bm7Pry_mW9NleH-KIu0e9HX6k-XNZmttPF-bj13MGX25XhuW_AdQVsLY</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Hidaka, Tomonori</creator><creator>Shide, Kotaro</creator><creator>Shimoda, Haruko</creator><creator>Kameda, Takurou</creator><creator>Toyama, Keiko</creator><creator>Katayose, Keiko</creator><creator>Kubuki, Youko</creator><creator>Nagata, Kenji</creator><creator>Takenaka, Katsuto</creator><creator>Akashi, Koichi</creator><creator>Okamura, Takashi</creator><creator>Niho, Yoshiyuki</creator><creator>Mizoguchi, Hideaki</creator><creator>Omine, Mitsuhiro</creator><creator>Ozawa, Keiya</creator><creator>Harada, Mine</creator><creator>Shimoda, Kazuya</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>200910</creationdate><title>The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan</title><author>Hidaka, Tomonori ; 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The presence of specific cytogenetic abnormalities, such as sole abnormalities of chromosome 13q−, 20q−, or −7/7q−, is reported to have the influence on the prognosis of primary myelofibrosis. We analyzed the data from the prospective survey of Japanese primary myelofibrosis patients which was conducted from 1999 to clarify the impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis. A total of 202 primary myelofibrosis patients had the cytogenetic and the prognostic data. Eighty (40%) out of 202 cases had cytogenetic abnormalities, and an association was evident for platelet counts. Although the presence of an abnormal karyotype did not affect the prognosis, primary myelofibrosis patients with cytogenetic abnormalities other than 13q− and 20q− showed an inferior prognosis compared to patients with a normal karyotype or sole 13q− or 20q− abnormalities. Patients with an unfavorable cytogenetic profile (abnormal cytogenetics other than 13q− or 20q−) also had a greater tendency to transform to leukemia than patients with a favorable cytogenetic profile (normal cytogenetics, sole abnormalities of either chromosome 13q−, or 20q−). Abnormal cytogenetics other than 13q− or 20q− in primary myelofibrosis patients has the poor prognostic effect for both survival and the risk of leukemic transformation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19549278</pmid><doi>10.1111/j.1600-0609.2009.01298.x</doi><tpages>6</tpages></addata></record> |
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| subjects | 13q 20q 7/7q Adolescent Adult Aged Aged, 80 and over Cell Transformation, Neoplastic - genetics Chromosome Aberrations Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 7 cytogenetic abnormalities Humans Japan - epidemiology Leukemia - etiology Male Middle Aged primary myelofibrosis Primary Myelofibrosis - diagnosis Primary Myelofibrosis - epidemiology Primary Myelofibrosis - genetics Prognosis Survival Analysis Young Adult |
| title | The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan |
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