Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats
The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological s...
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| Veröffentlicht in: | Behavioural brain research 2010-06, Vol.210 (1), p.140-142 |
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| container_title | Behavioural brain research |
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| creator | Vigil, Fabio Antônio Borges Oliveira-Silva, Ieda de Fátima Ferreira, Lívia Freire Pereira, Silvia Rejane Castanheira Ribeiro, Angela Maria |
| description | The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function. |
| doi_str_mv | 10.1016/j.bbr.2010.02.019 |
| format | Article |
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The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.02.019</identifier><identifier>PMID: 20153779</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>5-HIAA ; Analysis of Variance ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Fundamental and applied biological sciences. 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The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.</description><subject>5-HIAA</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - metabolism</subject><subject>Morris Water Maze</subject><subject>Neuropsychological Tests</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Pyrithiamine</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin - metabolism</subject><subject>Space Perception - physiology</subject><subject>Spatial learning and memory</subject><subject>Thalamus</subject><subject>Thalamus - metabolism</subject><subject>Thiamine deficiency</subject><subject>Thiamine Deficiency - chemically induced</subject><subject>Thiamine Deficiency - complications</subject><subject>Thiamine Deficiency - metabolism</subject><subject>Time Factors</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq0KVLa0P6AXlAvilGX8FW_UU4WgVELiAL3WmjgT8CofW9uLtP8eR7ulNyofrJGe9_X4YewrhyUHXl2ul00TlgLyDGIJvP7AFnxlRGm0qo_YIjNVqaRYnbBPMa4BQIHmH9lJjmhpTL1gvx82mDz2xUDDFHZFS513PsUCx7ZIz9jj4F0RKUxpGik85WGghM3U-0SFe8bxiQo_ZtRncqRDAY2pCJjiZ3bcYR_py-E-Zb9urh-vbsu7-x8_r77flU5xlcrakNEtyUrko3ljuqpDXQvtoJMcSWitgSh_oAFAFHrV1Vpjq7QBarmSp-xi37sJ058txWQHHx31PY40baM1KretuID_k1KquuZy7uR70oUpxkCd3QQ_YNhZDnb2b9c2-7ezfwvCZv85c3Zo3zYDtW-Jv8IzcH4AMDrsu4Cj8_EfJyqpuZgf_7bnKFt78RRsnK06an0gl2w7-XfWeAUKm6Ju</recordid><startdate>20100626</startdate><enddate>20100626</enddate><creator>Vigil, Fabio Antônio Borges</creator><creator>Oliveira-Silva, Ieda de Fátima</creator><creator>Ferreira, Lívia Freire</creator><creator>Pereira, Silvia Rejane Castanheira</creator><creator>Ribeiro, Angela Maria</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20100626</creationdate><title>Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats</title><author>Vigil, Fabio Antônio Borges ; Oliveira-Silva, Ieda de Fátima ; Ferreira, Lívia Freire ; Pereira, Silvia Rejane Castanheira ; Ribeiro, Angela Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-97e75de36262651b7f6fa5925c0f31ae25550ee000b00aa258f955ad4570ed143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>5-HIAA</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. 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| subjects | 5-HIAA Analysis of Variance Animals Behavioral psychophysiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Hydroxyindoleacetic Acid - metabolism Male Maze Learning - physiology Memory Disorders - etiology Memory Disorders - metabolism Morris Water Maze Neuropsychological Tests Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyrithiamine Rats Rats, Wistar Serotonin - metabolism Space Perception - physiology Spatial learning and memory Thalamus Thalamus - metabolism Thiamine deficiency Thiamine Deficiency - chemically induced Thiamine Deficiency - complications Thiamine Deficiency - metabolism Time Factors |
| title | Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats |
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