Increased phosphoribosylpyrophosphate synthetase activity in fibroblasts of hypoxanthine-guanine phosphoribosyl transferase deficient patients

An increased activity of phosphoribosylpyrophosphate synthetase at physiological levels of inorganic phosphate is demonstrated in extracts of skin fibroblast cultures derived from a patient with Lesch-Nyhan syndrome. This eccessive response of the phosphoribosylpyrophosphate synthetase at physiologi...

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Veröffentlicht in:	Biochemical and biophysical research communications 1979-03, Vol.87 (2), p.380-387
Hauptverfasser:	Torrelio, B.Marina, Paz, Mercedes A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Division Cells, Cultured Female Fibroblasts Humans Hypoxanthine Phosphoribosyltransferase - deficiency Lesch-Nyhan Syndrome - enzymology Male Phosphotransferases - metabolism Ribose-Phosphate Pyrophosphokinase - metabolism Skin - enzymology
Online-Zugang:	Volltext
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