Pyridones as Potential Antitumor Agents
Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active. At least two oxygen-con...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1979-07, Vol.68 (7), p.816-819 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 68 |
| creator | Hwang, Deng Ruey Driscoll, John S. |
| description | Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active. At least two oxygen-containing functional groups are required for P-388 activity, and the 2,3-isomeric arrangement provides the greatest activity. Carbamate or acyloxy groups in the 3-position produced the most active 2-pyridones. |
| doi_str_mv | 10.1002/jps.2600680707 |
| format | Article |
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Of the 32 compounds tested, 10 were active. At least two oxygen-containing functional groups are required for P-388 activity, and the 2,3-isomeric arrangement provides the greatest activity. Carbamate or acyloxy groups in the 3-position produced the most active 2-pyridones.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600680707</identifier><identifier>PMID: 458596</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; antineoplastic activity ; Antineoplastic agents ; Antineoplastic Agents - chemical synthesis ; Antineoplastic agents, potential—pyridone derivatives, structure-activity relationships, mice ; Leukemia, Experimental - drug therapy ; Mice ; potential-pyridone derivatives ; Pyridone derivatives-antineoplastic activity ; Pyridone derivatives—antineoplastic activity, structure-activity relationships, mice ; Pyridones - chemical synthesis ; Pyridones - pharmacology ; Structure-Activity Relationship ; structure-activity relationships ; Structured-activity relationships-pyridone derivatives ; Structured-activity relationships—pyridone derivatives, antineoplastic activity, mice</subject><ispartof>Journal of pharmaceutical sciences, 1979-07, Vol.68 (7), p.816-819</ispartof><rights>1979 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3417-814d252f60186ba250bdaeeb35b6536e06b088a9717569651ee21639e2922a6b3</citedby><cites>FETCH-LOGICAL-c3417-814d252f60186ba250bdaeeb35b6536e06b088a9717569651ee21639e2922a6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600680707$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600680707$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/458596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Deng Ruey</creatorcontrib><creatorcontrib>Driscoll, John S.</creatorcontrib><title>Pyridones as Potential Antitumor Agents</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active. At least two oxygen-containing functional groups are required for P-388 activity, and the 2,3-isomeric arrangement provides the greatest activity. Carbamate or acyloxy groups in the 3-position produced the most active 2-pyridones.</description><subject>Animals</subject><subject>antineoplastic activity</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic agents, potential—pyridone derivatives, structure-activity relationships, mice</subject><subject>Leukemia, Experimental - drug therapy</subject><subject>Mice</subject><subject>potential-pyridone derivatives</subject><subject>Pyridone derivatives-antineoplastic activity</subject><subject>Pyridone derivatives—antineoplastic activity, structure-activity relationships, mice</subject><subject>Pyridones - chemical synthesis</subject><subject>Pyridones - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>structure-activity relationships</subject><subject>Structured-activity relationships-pyridone derivatives</subject><subject>Structured-activity relationships—pyridone derivatives, antineoplastic activity, mice</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1979</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURS3EVymsTAyZYEqxndiOx6pAoaogEkWMlpO8IpekKXYC9N9jlKqIATE9ye_ca_sgdErwgGBMLxcrN6AcY55ggcUO6hFGccgxEbuo5wEaRiyWh-jIuQX2GGbsAO3HLGGS99BFuramqJfgAu2CtG5g2RhdBkM_mraqbTB88UfuGO3NdengZDP76Onmeja6DacP47vRcBrmUUxEmJC4oIzO_fUJzzRlOCs0QBaxjLOIA-YZThItBRGMS84IACU8kkAlpZpnUR-dd70rW7-14BpVGZdDWeol1K1TImYSi0h4cNCBua2dszBXK2sqbdeKYPUtRnkx6keMD5xtmtusgmKLdyb8WnbrD1PC-p8yNUkff1WHXda4Bj63WW1fFfdvZer5fqxIOrmajcaxmno-6XjwJt8NWOVyA8scCmMhb1RRm79-8QX9jI6D</recordid><startdate>197907</startdate><enddate>197907</enddate><creator>Hwang, Deng Ruey</creator><creator>Driscoll, John S.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197907</creationdate><title>Pyridones as Potential Antitumor Agents</title><author>Hwang, Deng Ruey ; Driscoll, John S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3417-814d252f60186ba250bdaeeb35b6536e06b088a9717569651ee21639e2922a6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1979</creationdate><topic>Animals</topic><topic>antineoplastic activity</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - chemical synthesis</topic><topic>Antineoplastic agents, potential—pyridone derivatives, structure-activity relationships, mice</topic><topic>Leukemia, Experimental - drug therapy</topic><topic>Mice</topic><topic>potential-pyridone derivatives</topic><topic>Pyridone derivatives-antineoplastic activity</topic><topic>Pyridone derivatives—antineoplastic activity, structure-activity relationships, mice</topic><topic>Pyridones - chemical synthesis</topic><topic>Pyridones - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>structure-activity relationships</topic><topic>Structured-activity relationships-pyridone derivatives</topic><topic>Structured-activity relationships—pyridone derivatives, antineoplastic activity, mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Deng Ruey</creatorcontrib><creatorcontrib>Driscoll, John S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Deng Ruey</au><au>Driscoll, John S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyridones as Potential Antitumor Agents</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1979-07</date><risdate>1979</risdate><volume>68</volume><issue>7</issue><spage>816</spage><epage>819</epage><pages>816-819</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Based on the finding that 3-acetoxy-2-pyridone had reproducible activity against murine P-388 lymphocytic leukemia, derivatives in this series were synthesized and evaluated to determine structural parameters important for activity. Of the 32 compounds tested, 10 were active. At least two oxygen-containing functional groups are required for P-388 activity, and the 2,3-isomeric arrangement provides the greatest activity. Carbamate or acyloxy groups in the 3-position produced the most active 2-pyridones.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>458596</pmid><doi>10.1002/jps.2600680707</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1979-07, Vol.68 (7), p.816-819 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals antineoplastic activity Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic agents, potential—pyridone derivatives, structure-activity relationships, mice Leukemia, Experimental - drug therapy Mice potential-pyridone derivatives Pyridone derivatives-antineoplastic activity Pyridone derivatives—antineoplastic activity, structure-activity relationships, mice Pyridones - chemical synthesis Pyridones - pharmacology Structure-Activity Relationship structure-activity relationships Structured-activity relationships-pyridone derivatives Structured-activity relationships—pyridone derivatives, antineoplastic activity, mice |
| title | Pyridones as Potential Antitumor Agents |
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