Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication
Background: The Rome III criteria classify patients with a positive relationship between symptoms and reflux episodes but a physiological oesophageal acid exposure time as having gastro‐oesophageal reflux disease (GORD) with an acid hypersensitive oesophagus. The long‐term outcome of antireflux surg...
Gespeichert in:
| Veröffentlicht in: | British journal of surgery 2009-09, Vol.96 (9), p.1023-1030 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1030 |
|---|---|
| container_issue | 9 |
| container_start_page | 1023 |
| container_title | British journal of surgery |
| container_volume | 96 |
| creator | Broeders, J. A. Draaisma, W. A. Bredenoord, A. J. de Vries, D. R. Rijnhart-de Jong, H. G. Smout, A. J. Gooszen, H. G. |
| description | Background:
The Rome III criteria classify patients with a positive relationship between symptoms and reflux episodes but a physiological oesophageal acid exposure time as having gastro‐oesophageal reflux disease (GORD) with an acid hypersensitive oesophagus. The long‐term outcome of antireflux surgery in these patients was investigated.
Methods:
Outcomes of Nissen fundoplication in 28 patients with GORD refractory to proton‐pump inhibitors (PPIs) and oesophageal acid hypersensitivity (group 1) were compared with those of 126 patients with pathological acid exposure (group 2).
Results:
Fundoplication had a similar effect in both groups. Three months after surgery, total acid exposure time and the prevalence of oesophagitis had decreased, whereas mean lower oesophageal pressure had increased. The percentage of patients using PPIs was reduced from 83 to 4 per cent in group 1 and from 86·1 to 7·4 per cent in group 2 (both P < 0·001). Quality of life measured on a scale from 0 to 100 improved from 52 to 69 (P = 0·009) and 64 (P < 0·001) respectively. The percentage of patients with resolved or improved symptoms at 5 years was similar.
Conclusion:
Patients with oesophageal acid hypersensitivity benefit from Nissen fundoplication as much as those with pathological acid exposure. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Anti‐reflux surgery works |
| doi_str_mv | 10.1002/bjs.6684 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_745903666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>745903666</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4204-81e1dc8bb89de9fe6be8c820c09e9397d27b3544044ff2b2fac948b78958e4aa3</originalsourceid><addsrcrecordid>eNp90clOwzAQBmALgaAsEk-AfAFOAW_xcqSItag9AELiYjnOBAxpEuIU6NuTigI3TnOYT79G8yO0S8kRJYQdZy_xSEotVtCAcpkmjEq9igaEEJVQzvgG2ozxhRDKScrW0QY1UjHD6QDdTSDWzbN7Aldi50OOn-cNtBGqGLrwHro5DhFXdYcd9nXVtS5UefCuC3WFuxqPQ-wtLmZVXjflcrGN1gpXRthZzi10f352d3qZ3Ewurk5PbhIvGBGJpkBzr7NMmxxMATID7TUjnhgw3KicqYynQhAhioJlrHDeCJ0pbVINwjm-hQ6_c5u2fptB7Ow0RA9l6SqoZ9EqkRrCpZS9PPhXStVLLVUP95Zwlk0ht00bpq6d25-P9WB_CVz0rixaV_kQfx2jmhpKF0HJt_sIJcz_cohdNGb7xuyiMTu8vl3MPx9iB5-_3rWv_XFcpfZhfGFHw8cRGV1f2iH_As6hl6Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67590867</pqid></control><display><type>article</type><title>Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Broeders, J. A. ; Draaisma, W. A. ; Bredenoord, A. J. ; de Vries, D. R. ; Rijnhart-de Jong, H. G. ; Smout, A. J. ; Gooszen, H. G.</creator><creatorcontrib>Broeders, J. A. ; Draaisma, W. A. ; Bredenoord, A. J. ; de Vries, D. R. ; Rijnhart-de Jong, H. G. ; Smout, A. J. ; Gooszen, H. G.</creatorcontrib><description>Background:
The Rome III criteria classify patients with a positive relationship between symptoms and reflux episodes but a physiological oesophageal acid exposure time as having gastro‐oesophageal reflux disease (GORD) with an acid hypersensitive oesophagus. The long‐term outcome of antireflux surgery in these patients was investigated.
Methods:
Outcomes of Nissen fundoplication in 28 patients with GORD refractory to proton‐pump inhibitors (PPIs) and oesophageal acid hypersensitivity (group 1) were compared with those of 126 patients with pathological acid exposure (group 2).
Results:
Fundoplication had a similar effect in both groups. Three months after surgery, total acid exposure time and the prevalence of oesophagitis had decreased, whereas mean lower oesophageal pressure had increased. The percentage of patients using PPIs was reduced from 83 to 4 per cent in group 1 and from 86·1 to 7·4 per cent in group 2 (both P < 0·001). Quality of life measured on a scale from 0 to 100 improved from 52 to 69 (P = 0·009) and 64 (P < 0·001) respectively. The percentage of patients with resolved or improved symptoms at 5 years was similar.
Conclusion:
Patients with oesophageal acid hypersensitivity benefit from Nissen fundoplication as much as those with pathological acid exposure. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Anti‐reflux surgery works</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.6684</identifier><identifier>PMID: 19672931</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged, 80 and over ; Biological and medical sciences ; Contraindications ; Drug Resistance ; Endoscopy, Gastrointestinal ; Esophagitis, Peptic - etiology ; Female ; Fundoplication ; Gastric Acid - physiology ; Gastroesophageal Reflux - complications ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - surgery ; General aspects ; Humans ; Hydrogen-Ion Concentration ; Hypersensitivity - complications ; Male ; Manometry ; Medical sciences ; Middle Aged ; Omeprazole - therapeutic use ; Proton Pump Inhibitors - therapeutic use ; Treatment Outcome ; Young Adult</subject><ispartof>British journal of surgery, 2009-09, Vol.96 (9), p.1023-1030</ispartof><rights>Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><rights>(c) 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4204-81e1dc8bb89de9fe6be8c820c09e9397d27b3544044ff2b2fac948b78958e4aa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.6684$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.6684$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,1416,23921,23922,25131,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21819117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19672931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Broeders, J. A.</creatorcontrib><creatorcontrib>Draaisma, W. A.</creatorcontrib><creatorcontrib>Bredenoord, A. J.</creatorcontrib><creatorcontrib>de Vries, D. R.</creatorcontrib><creatorcontrib>Rijnhart-de Jong, H. G.</creatorcontrib><creatorcontrib>Smout, A. J.</creatorcontrib><creatorcontrib>Gooszen, H. G.</creatorcontrib><title>Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
The Rome III criteria classify patients with a positive relationship between symptoms and reflux episodes but a physiological oesophageal acid exposure time as having gastro‐oesophageal reflux disease (GORD) with an acid hypersensitive oesophagus. The long‐term outcome of antireflux surgery in these patients was investigated.
Methods:
Outcomes of Nissen fundoplication in 28 patients with GORD refractory to proton‐pump inhibitors (PPIs) and oesophageal acid hypersensitivity (group 1) were compared with those of 126 patients with pathological acid exposure (group 2).
Results:
Fundoplication had a similar effect in both groups. Three months after surgery, total acid exposure time and the prevalence of oesophagitis had decreased, whereas mean lower oesophageal pressure had increased. The percentage of patients using PPIs was reduced from 83 to 4 per cent in group 1 and from 86·1 to 7·4 per cent in group 2 (both P < 0·001). Quality of life measured on a scale from 0 to 100 improved from 52 to 69 (P = 0·009) and 64 (P < 0·001) respectively. The percentage of patients with resolved or improved symptoms at 5 years was similar.
Conclusion:
Patients with oesophageal acid hypersensitivity benefit from Nissen fundoplication as much as those with pathological acid exposure. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Anti‐reflux surgery works</description><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Contraindications</subject><subject>Drug Resistance</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Esophagitis, Peptic - etiology</subject><subject>Female</subject><subject>Fundoplication</subject><subject>Gastric Acid - physiology</subject><subject>Gastroesophageal Reflux - complications</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastroesophageal Reflux - surgery</subject><subject>General aspects</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Hypersensitivity - complications</subject><subject>Male</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Omeprazole - therapeutic use</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90clOwzAQBmALgaAsEk-AfAFOAW_xcqSItag9AELiYjnOBAxpEuIU6NuTigI3TnOYT79G8yO0S8kRJYQdZy_xSEotVtCAcpkmjEq9igaEEJVQzvgG2ozxhRDKScrW0QY1UjHD6QDdTSDWzbN7Aldi50OOn-cNtBGqGLrwHro5DhFXdYcd9nXVtS5UefCuC3WFuxqPQ-wtLmZVXjflcrGN1gpXRthZzi10f352d3qZ3Ewurk5PbhIvGBGJpkBzr7NMmxxMATID7TUjnhgw3KicqYynQhAhioJlrHDeCJ0pbVINwjm-hQ6_c5u2fptB7Ow0RA9l6SqoZ9EqkRrCpZS9PPhXStVLLVUP95Zwlk0ht00bpq6d25-P9WB_CVz0rixaV_kQfx2jmhpKF0HJt_sIJcz_cohdNGb7xuyiMTu8vl3MPx9iB5-_3rWv_XFcpfZhfGFHw8cRGV1f2iH_As6hl6Y</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Broeders, J. A.</creator><creator>Draaisma, W. A.</creator><creator>Bredenoord, A. J.</creator><creator>de Vries, D. R.</creator><creator>Rijnhart-de Jong, H. G.</creator><creator>Smout, A. J.</creator><creator>Gooszen, H. G.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200909</creationdate><title>Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication</title><author>Broeders, J. A. ; Draaisma, W. A. ; Bredenoord, A. J. ; de Vries, D. R. ; Rijnhart-de Jong, H. G. ; Smout, A. J. ; Gooszen, H. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4204-81e1dc8bb89de9fe6be8c820c09e9397d27b3544044ff2b2fac948b78958e4aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Contraindications</topic><topic>Drug Resistance</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Esophagitis, Peptic - etiology</topic><topic>Female</topic><topic>Fundoplication</topic><topic>Gastric Acid - physiology</topic><topic>Gastroesophageal Reflux - complications</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastroesophageal Reflux - surgery</topic><topic>General aspects</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Hypersensitivity - complications</topic><topic>Male</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Omeprazole - therapeutic use</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Broeders, J. A.</creatorcontrib><creatorcontrib>Draaisma, W. A.</creatorcontrib><creatorcontrib>Bredenoord, A. J.</creatorcontrib><creatorcontrib>de Vries, D. R.</creatorcontrib><creatorcontrib>Rijnhart-de Jong, H. G.</creatorcontrib><creatorcontrib>Smout, A. J.</creatorcontrib><creatorcontrib>Gooszen, H. G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Broeders, J. A.</au><au>Draaisma, W. A.</au><au>Bredenoord, A. J.</au><au>de Vries, D. R.</au><au>Rijnhart-de Jong, H. G.</au><au>Smout, A. J.</au><au>Gooszen, H. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2009-09</date><risdate>2009</risdate><volume>96</volume><issue>9</issue><spage>1023</spage><epage>1030</epage><pages>1023-1030</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Background:
The Rome III criteria classify patients with a positive relationship between symptoms and reflux episodes but a physiological oesophageal acid exposure time as having gastro‐oesophageal reflux disease (GORD) with an acid hypersensitive oesophagus. The long‐term outcome of antireflux surgery in these patients was investigated.
Methods:
Outcomes of Nissen fundoplication in 28 patients with GORD refractory to proton‐pump inhibitors (PPIs) and oesophageal acid hypersensitivity (group 1) were compared with those of 126 patients with pathological acid exposure (group 2).
Results:
Fundoplication had a similar effect in both groups. Three months after surgery, total acid exposure time and the prevalence of oesophagitis had decreased, whereas mean lower oesophageal pressure had increased. The percentage of patients using PPIs was reduced from 83 to 4 per cent in group 1 and from 86·1 to 7·4 per cent in group 2 (both P < 0·001). Quality of life measured on a scale from 0 to 100 improved from 52 to 69 (P = 0·009) and 64 (P < 0·001) respectively. The percentage of patients with resolved or improved symptoms at 5 years was similar.
Conclusion:
Patients with oesophageal acid hypersensitivity benefit from Nissen fundoplication as much as those with pathological acid exposure. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Anti‐reflux surgery works</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19672931</pmid><doi>10.1002/bjs.6684</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1323 |
| ispartof | British journal of surgery, 2009-09, Vol.96 (9), p.1023-1030 |
| issn | 0007-1323 1365-2168 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_745903666 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Aged, 80 and over Biological and medical sciences Contraindications Drug Resistance Endoscopy, Gastrointestinal Esophagitis, Peptic - etiology Female Fundoplication Gastric Acid - physiology Gastroesophageal Reflux - complications Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - surgery General aspects Humans Hydrogen-Ion Concentration Hypersensitivity - complications Male Manometry Medical sciences Middle Aged Omeprazole - therapeutic use Proton Pump Inhibitors - therapeutic use Treatment Outcome Young Adult |
| title | Oesophageal acid hypersensitivity is not a contraindication to Nissen fundoplication |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T05%3A39%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oesophageal%20acid%20hypersensitivity%20is%20not%20a%20contraindication%20to%20Nissen%20fundoplication&rft.jtitle=British%20journal%20of%20surgery&rft.au=Broeders,%20J.%20A.&rft.date=2009-09&rft.volume=96&rft.issue=9&rft.spage=1023&rft.epage=1030&rft.pages=1023-1030&rft.issn=0007-1323&rft.eissn=1365-2168&rft.coden=BJSUAM&rft_id=info:doi/10.1002/bjs.6684&rft_dat=%3Cproquest_pubme%3E745903666%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67590867&rft_id=info:pmid/19672931&rfr_iscdi=true |