Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myeloma

The abnormal expression of Annexin II (AnxA2, A2) has been associated with the development of tumors; however, its expression and function in multiple myeloma (MM) is less known. We compared the expression of AnxA2 in primary myeloma cells from MM patients with that in normal plasma cells from norma...

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Veröffentlicht in:	International journal of hematology 2009-09, Vol.90 (2), p.177-185
Hauptverfasser:	Bao, Hongyu, Jiang, Miao, Zhu, Mingqing, Sheng, Fei, Ruan, Jia, Ruan, Changgeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A2 - genetics Annexin A2 - metabolism Apoptosis - physiology Biological and medical sciences Blotting, Western Cell Division - physiology Cell Line, Tumor Flow Cytometry Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Medicine Medicine & Public Health Multiple Myeloma - genetics Multiple Myeloma - pathology Multiple Myeloma - physiopathology Neoplasm Invasiveness Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Oncology Original Article Plasma Cells - pathology Plasma Cells - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering
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